{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:48:49Z","timestamp":1782409729913,"version":"3.54.5"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHM 2663\/7-1"],"award-info":[{"award-number":["SCHM 2663\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BA 2168\/25-1"],"award-info":[{"award-number":["BA 2168\/25-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FFF Nachwuchsforscher-F\u00f6rderung","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Translation is a crucial regulatory mechanism involved in several diseases, including cancer, where pro-inflammatory conditions within the microenvironment have been shown to modulate the translation of specific mRNAs. In the present study, we focused on the regulation of insulin growth factor-like family member 1 (\n                    <jats:italic>IGFL1<\/jats:italic>\n                    ) in MCF7 breast cancer cells in response to pro-inflammatory IL-1\u03b2 and observed an induction of both transcription and translation. We characterized the 3\u2019 untranslated region as regulatory hub for the post-transcriptional regulation and identified a distinct G-rich region to confer the IL-1\u03b2-dependent translational increase. Our study therefore provides new insights into the translation regulation of\n                    <jats:italic>IGFL1<\/jats:italic>\n                    in the context of an inflammatory tumor microenvironment.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0342288","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:26:51Z","timestamp":1782408411000},"page":"e0342288","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced IGFL1 translation in response to IL-1\u03b2 is controlled by distinct 3\u2019UTR 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