{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:28:18Z","timestamp":1782311298584,"version":"3.54.5"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016801","name":"Natural Science Foundation of Nanchang Municipality","doi-asserted-by":"publisher","award":["2023YLWS019"],"award-info":[{"award-number":["2023YLWS019"]}],"id":[{"id":"10.13039\/100016801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>AIDS is a major public health issue. As a transportation and economic hub in central China, Nanchang has frequent population mobility and unbalanced regional development, making it urgent to explore the prevalence characteristics of HIV\/AIDS. Based on HIV\/AIDS surveillance data in Nanchang from 2012 to 2021, this study innovatively integrates the Joinpoint regression model with spatiotemporal geographic information technology to construct an epidemiological analysis framework of \u201ctime-space-population\u201d. The results show that a total of 3,789 HIV\/AIDS infection cases were reported in the decade, with the growth rate of new cases (5.4%) significantly higher than the population growth rate (2.1%). There is a negative correlation between incidence and mortality, and men and the elderly (\u226565 years old) are at prominent infection risk. Spatially, cases show significant heterogeneity, with \u201chigh-high\u201d clustering areas concentrated in the city center and gradually expanding to surrounding areas, which is related to factors such as population density. The study provides a scientific basis for targeted interventions for men and the elderly, optimization of prevention and control strategies, and regional collaboration.<\/jats:p>","DOI":"10.1371\/journal.pone.0342375","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:35:50Z","timestamp":1770316550000},"page":"e0342375","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatiotemporal aggregation and population distribution characteristics of HIV\/AIDS in Nanchang city: A monitoring analysis from 2012\u20132021"],"prefix":"10.1371","volume":"21","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9769-4269","authenticated-orcid":true,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"issue":"11","key":"pone.0342375.ref001","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S1473-3099(13)70245-7","article-title":"HIV prevalence in China: integration of surveillance data and a systematic review","volume":"13","author":"L Zhang","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"10092","key":"pone.0342375.ref002","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0140-6736(17)31920-7","article-title":"The global HIV\/AIDS epidemic-progress and challenges","volume":"390","author":"Lancet The","year":"2017","journal-title":"Lancet"},{"key":"pone.0342375.ref003","first-page":"8935314","article-title":"Modeling and Control for HIV\/AIDS Transmission in China Based on Data from 2004 to 2016","volume":"2017","author":"Z Li","year":"2017","journal-title":"Comput Math Methods Med"},{"issue":"1","key":"pone.0342375.ref004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/COH.0000000000000588","article-title":"HIV treatment and prevention 2019: current standards of care","volume":"15","author":"N Phanuphak","year":"2020","journal-title":"Curr Opin HIV AIDS"},{"key":"pone.0342375.ref005","doi-asserted-by":"crossref","first-page":"994277","DOI":"10.3389\/fpubh.2022.994277","article-title":"Spatial disparities of HIV prevalence in South Africa. Do sociodemographic, behavioral, and biological factors explain this spatial variability?","volume":"10","author":"CLJ Ugwu","year":"2022","journal-title":"Front Public Health"},{"issue":"2","key":"pone.0342375.ref006","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/0033354921990373","article-title":"A Census Tract-Level Examination of Differences in Social Determinants of Health Among People With HIV, by Race\/Ethnicity and Geography, United States and Puerto Rico, 2017","volume":"137","author":"S Johnson Lyons","year":"2022","journal-title":"Public Health Rep"},{"key":"pone.0342375.ref007","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijid.2019.02.016","article-title":"Epidemiological analyses of regional and age differences of HIV\/AIDS prevalence in China, 2004-2016","volume":"81","author":"Y-C Qiao","year":"2019","journal-title":"Int J Infect Dis"},{"issue":"1","key":"pone.0342375.ref008","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1038\/s41598-020-63141-1","article-title":"Age-Period-Cohort Analysis of HIV Mortality in China: Data from the Global Burden of Disease Study 2016","volume":"10","author":"D Gao","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0342375.ref009","article-title":"Spatiotemporal Analysis of HIV\/AIDS Incidence in China From 2009 to 2019 and Its Association With Socioeconomic Factors: Geospatial Study","volume":"10","author":"Z Xie","year":"2024","journal-title":"JMIR Public Health Surveill"},{"issue":"1","key":"pone.0342375.ref010","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1186\/s12889-020-09977-8","article-title":"Epidemiological and time series analysis on the incidence and death of AIDS and HIV in China","volume":"20","author":"B Xu","year":"2020","journal-title":"BMC Public Health"},{"issue":"1","key":"pone.0342375.ref011","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12889-021-10196-y","article-title":"The HIV epidemic in Colombia: spatial and temporal trends analysis","volume":"21","author":"JF Montana","year":"2021","journal-title":"BMC Public Health"},{"key":"pone.0342375.ref012","doi-asserted-by":"crossref","first-page":"116760","DOI":"10.1016\/j.marpolbul.2024.116760","article-title":"Identify the seasonal differences in water quality and pollution sources between river-connected and gate-controlled lakes in the Yangtze River basin","volume":"206","author":"Y Bai","year":"2024","journal-title":"Mar Pollut Bull"},{"key":"pone.0342375.ref013","doi-asserted-by":"crossref","first-page":"109096","DOI":"10.1016\/j.ecolind.2022.109096","article-title":"Water quality assessment and the influence of landscape metrics at multiple scales in Poyang Lake basin","volume":"141","author":"J Xu","year":"2022","journal-title":"Ecological Indicators"},{"key":"pone.0342375.ref014","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/10807039.2025.2451742","article-title":"Associations between short-term exposure to ambient air pollution and stroke mortality in Nanchang, China","volume":"31","author":"H Liao","year":"2025","journal-title":"Human and Ecological Risk Assessment: An International Journal"},{"issue":"6","key":"pone.0342375.ref015","first-page":"539","article-title":"Application of spatial autocorrelation method in epidemiology","volume":"32","author":"Q Jiang","year":"2011","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"3","key":"pone.0342375.ref016","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10109-020-00323-5","article-title":"Uncovering a positive and negative spatial autocorrelation mixture pattern: a spatial analysis of breast cancer incidences in Broward County, Florida, 2000\u20132010","volume":"22","author":"L Hu","year":"2020","journal-title":"J Geogr Syst"},{"issue":"4","key":"pone.0342375.ref017","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/diseases10040106","article-title":"Spatial Co-Clustering of Tuberculosis and HIV in Ethiopia","volume":"10","author":"LL Gemechu","year":"2022","journal-title":"Diseases"},{"key":"pone.0342375.ref018","article-title":"The Distribution and Associated Factors of HIV\/AIDS Among Youths in Guangxi, China, From 2014 to 2021: Bayesian Spatiotemporal Analysis","volume":"10","author":"J Li","year":"2024","journal-title":"JMIR Public Health Surveill"},{"issue":"1","key":"pone.0342375.ref019","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11904-019-00478-x","article-title":"Optimizing Treatment for Adults with HIV\/AIDS in China: Successes over Two Decades and Remaining Challenges","volume":"17","author":"W Cao","year":"2020","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"10","key":"pone.0342375.ref020","article-title":"Tracking the evolution of HIV\/AIDS in China from 1989-2009 to inform future prevention and control efforts","volume":"6","author":"Z Jia","year":"2011","journal-title":"PLoS One"},{"issue":"33","key":"pone.0342375.ref021","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2024.29.33.2300655","article-title":"Differences between males and females in infectious diseases notifications in the EU\/EEA, 2012 to 2021","volume":"29","author":"J Beaut\u00e9","year":"2024","journal-title":"Euro Surveill"},{"issue":"27","key":"pone.0342375.ref022","first-page":"156","article-title":"Analysis of AIDS epidemic trend and characteristics in Xinjian District of Nanchang City from 2014 to 2018","volume":"26","author":"F Wang","year":"2019","journal-title":"China Modern Medicine"},{"issue":"4","key":"pone.0342375.ref023","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/QAI.0000000000003495","article-title":"Brief Report: Aging With HIV: An Epidemiological Profile of Persons With Diagnosed HIV Aged 50 Years and Older in New York State, 2012-2021","volume":"97","author":"Z Wang","year":"2024","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"24","key":"pone.0342375.ref024","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.3390\/ijerph192416917","article-title":"HIV Detection and Delayed Diagnosis: A Time Series Analysis in China","volume":"19","author":"J Chen","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"pone.0342375.ref025","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1186\/s12879-019-4559-1","article-title":"The prevalence of HIV among MSM in China: a large-scale systematic analysis","volume":"19","author":"M-J Dong","year":"2019","journal-title":"BMC Infect Dis"},{"issue":"8","key":"pone.0342375.ref026","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/ijerph13080794","article-title":"Shift in HIV\/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015","volume":"13","author":"Y Yan","year":"2016","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"pone.0342375.ref027","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/cid\/ciaa835","article-title":"The Enigma of the Human Immunodeficiency Virus (HIV) Epidemic in China","volume":"72","author":"Z Wu","year":"2021","journal-title":"Clin Infect Dis"},{"key":"pone.0342375.ref028","doi-asserted-by":"crossref","first-page":"652868","DOI":"10.3389\/fpubh.2021.652868","article-title":"Long-Term Changes of HIV\/AIDS Incidence Rate in China and the U.S. Population From 1994 to 2019: A Join-Point and Age-Period-Cohort Analysis","volume":"9","author":"Y Ma","year":"2021","journal-title":"Front Public Health"},{"issue":"27","key":"pone.0342375.ref029","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","article-title":"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men","volume":"363","author":"RM Grant","year":"2010","journal-title":"N Engl J Med"},{"issue":"05","key":"pone.0342375.ref030","first-page":"329","article-title":"Analysis of the Epidemic Situation of AIDS in Donghu District, Nanchang City from 1995 to 2014","volume":"21","author":"JH Min","year":"2015","journal-title":"Applied Preventive Medicine"},{"key":"pone.0342375.ref031","article-title":"Spatiotemporal Analysis of HIV\/AIDS Incidence in China From 2009 to 2019 and Its Association With Socioeconomic Factors: Geospatial Study","volume":"10","author":"Z Xie","year":"2024","journal-title":"JMIR Public Health Surveill"},{"issue":"7","key":"pone.0342375.ref032","doi-asserted-by":"crossref","DOI":"10.2105\/AJPH.2014.301997","article-title":"Connecting race and place: a county-level analysis of White, Black, and Hispanic HIV prevalence, poverty, and level of urbanization","volume":"104","author":"AS Vaughan","year":"2014","journal-title":"Am J Public Health"},{"issue":"5","key":"pone.0342375.ref033","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s11524-017-0198-2","article-title":"Place Still Matters: Racial\/Ethnic and Geographic Disparities in HIV Transmission and Disease Burden","volume":"94","author":"BM Brawner","year":"2017","journal-title":"J Urban Health"},{"issue":"5","key":"pone.0342375.ref034","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2105\/AJPH.2013.301864","article-title":"Geography should not be destiny: focusing HIV\/AIDS implementation research and programs on microepidemics in US neighborhoods","volume":"104","author":"A Nunn","year":"2014","journal-title":"Am J Public Health"},{"issue":"2","key":"pone.0342375.ref035","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/003335491613100210","article-title":"Online Hookup Sites for Meeting Sexual Partners Among Men Who Have Sex with Men in Rhode Island, 2013: A Call for Public Health Action","volume":"131","author":"PA Chan","year":"2016","journal-title":"Public Health Rep"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:35:58Z","timestamp":1770316558000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342375"}},"subtitle":[],"editor":[{"given":"Zhijie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0342375","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}