{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:46:19Z","timestamp":1773236779102,"version":"3.50.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DKTSG"},{"name":"ADORABLE","award":["KICH2.V4P.NN23.002"],"award-info":[{"award-number":["KICH2.V4P.NN23.002"]}]},{"DOI":"10.13039\/501100013955","name":"Astellas Pharma, Netherlands","doi-asserted-by":"publisher","award":["TransplantLines Biobank and Cohort study"],"award-info":[{"award-number":["TransplantLines Biobank and Cohort study"]}],"id":[{"id":"10.13039\/501100013955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007560","name":"Chiesi Pharmaceuticals","doi-asserted-by":"crossref","award":["PA-SP\/PRJ-2020-9136"],"award-info":[{"award-number":["PA-SP\/PRJ-2020-9136"]}],"id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NWO\/TTW","award":["14939"],"award-info":[{"award-number":["14939"]}]},{"DOI":"10.13039\/501100016238","name":"Ministerie van Economische Zaken en Klimaat","doi-asserted-by":"publisher","award":["PPP-2019-032 and PPP-2022-015"],"award-info":[{"award-number":["PPP-2019-032 and PPP-2022-015"]}],"id":[{"id":"10.13039\/501100016238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deceased donor kidney selection is largely determined by creatinine-based kidney function estimation. However, muscle wasting is common in potential donors and affects the accuracy of creatinine-based kidney function assessment. Cystatin C could serve as a muscle-mass independent alternative for this purpose. The primary aim of this study was to evaluate the associations of donor creatinine and cystatin C with recipient measured glomerular filtration (mGFR) at one year after transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using data from the prospective TransplantLines study, multivariable linear regression analyses were performed to examine the associations of donor plasma creatinine and cystatin C with recipient I\n                      <jats:sup>125<\/jats:sup>\n                      -iothalamate mGFR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Donor plasma creatinine and cystatin C data were available for 96 donor-recipient pairs. Median pre-donation creatinine and cystatin C concentrations were 56.0 [49.5\u201371.0] \u00b5mol\/L and 0.63 [0.50\u20130.82] mg\/L, respectively. Recipient mGFR data at one year after transplantation were available in 55 kidney transplant recipients. Mean recipient mGFR was 52.1\u2009\u00b1\u200917.0 ml\/min. Donor plasma creatinine was not associated with recipient mGFR (st. \u03b2 \u22120.19, 95% CI [\u22120.48 to 0.10], p\u2009=\u20090.21), while donor cystatin C was significantly associated with recipient graft function (st. \u03b2 \u22120.52, [\u22120.83 to \u22120.21], p\u2009=\u20090.002). The association of cystatin C and recipient mGFR remained materially unchanged after adjustment for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In deceased kidney donors, donor plasma creatinine is not associated with recipient mGFR, whereas donor cystatin is associated. Addition of cystatin C to the assessment of deceased kidney donors may provide additional information in difficult cases and improve the accuracy of deceased kidney donor selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0342497","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:42:53Z","timestamp":1773164573000},"page":"e0342497","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deceased kidney donor cystatin C and subsequent recipient measured glomerular filtration rate at one year after transplantation"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8270-1926","authenticated-orcid":true,"given":"Isabelle J. 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D.","family":"Leuvenink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny E.","family":"Kootstra-Ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H.","family":"de Borst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"van Londen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Stephan F.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3356-6791","authenticated-orcid":true,"given":"Stephan J. 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