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A total of 192 teeth presenting DH associated with root surface exposure were treated with one of four desensitizing agents: fluoride varnish (Duraphat \u2013 FLU, active control), bioactive ceramic solution (Biosilicate \u2013 BIOS), universal self-etching adhesive (Single Bond Universal \u2013 SBU), and a bioactive, photoactivated varnish containing PRG fillers (SPRG). DH was assessed using a visual analogue scale (VAS) to analyse intensity of sensitivity and a computerized visual scale (CoVAS) to observe the time course of sensibility at baseline, 7, 15, 30 days and 6 months post-treatment. Comparisons between groups were conducted using Fisher\u2019s exact test for qualitative variables and analysis of variance (ANOVA) for quantitative variables. Longitudinal outcomes (VAS and CoVAS) were evaluated using linear mixed-effects models, with post hoc comparisons performed using orthogonal contrasts. Statistical differences were found for VAS analysis (p\u2009&lt;\u20090.05). Comparing the desensitizers, FLU showed higher sensitivity than SBU, after 7 days. Comparing follow-up periods, a significant reduction in DH beginning at 7 days for BIOS and SBU, and at 15 days for FLU and SPRG. Regarding CoVAS time course, FLU exhibited a significantly shorter time course than SBU, after 15 days and 6 months of follow-up (p\u2009\u2264\u20090.05). SPRG was the only treatment that showed no difference in reaction time between 6 months and baseline (p\u2009&gt;\u20090.05). In conclusion, root exposure height and the presence of an antagonist tooth may influence the initial intensity of DH. All treatments reduced DH over 6 months. Only bioactive resin varnish maintained the same reaction time in all periods. Universal adhesive system had slowed pain reaction time compared to conventional fluoride varnish.<\/jats:p>","DOI":"10.1371\/journal.pone.0342651","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:22:43Z","timestamp":1771352563000},"page":"e0342651","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longevity of different in-office treatments for dentin hypersensitivity: A 6-month randomized and parallel clinical trial"],"prefix":"10.1371","volume":"21","author":[{"given":"Fernanda de Souza e Silva","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz Fraga","family":"Briso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-6259","authenticated-orcid":true,"given":"\u00c9rika 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