{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:01:12Z","timestamp":1790618472423,"version":"4.1.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016059","name":"Stichting Beatrixoord Noord-Nederland","doi-asserted-by":"publisher","award":["P3-10-23-6"],"award-info":[{"award-number":["P3-10-23-6"]}],"id":[{"id":"10.13039\/100016059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>People who have undergone dysvascular major lower limb amputation (LLA) are at high risk for adverse clinical outcomes, including undernutrition. However, prevalence of undernutrition in this population is unknown. Therefore, the aim of this study was to determine the nutritional intake and prevalence of undernutrition post-LLA, and to identify determinants of undernutrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective longitudinal observational study, adults who underwent a dysvascular major LLA were included in six hospitals (n\u2009=\u200981). At several measurement occasions following amputation (&lt;12 days, 5 weeks, 6 months, 9 months), participants\u2019 nutritional intake (24-hour recall) and nutritional status (Patient-Generated Subjective Global Assessment, body mass index, grip strength, mid upper arm circumference, and triceps skinfold) were determined. Furthermore, the Dutch Healthy Diet index was determined. Potential determinants of undernutrition, i.e., age, sex, Charlson comorbidity index, LLA level, uni\/bilateral LLA, education level, living situation, smoking status, pain level, and physical activity level, were assessed using mixed effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median [Q1; Q3] energy intake was 1647 [1178; 2199], 2053 [1516; 2340], 1920 [1263; 2240], and 1797 [1343; 2211] kcal\/day (p\u2009=\u20090.002), and protein intake was 76 [59; 100], 88 [68; 114], 84 [64; 101], and 75 [57; 97] grams\/day (p\u2009=\u20090.017) at &lt;12 days, 5 weeks, 6 months, and 9 months post-LLA, respectively. Prevalence of undernutrition was 83%, 56%, 28%, and 24%. Determinants of undernutrition were: living in a care facility (OR=6.2, p\u2009&lt;\u20090.001) and lower physical activity (OR=0.96 for every hour of physical activity\/week, p\u2009=\u20090.006). Need for nutritional intervention was present in 100%, 82%, 67% and 54% of participants at &lt;12 days, 5 weeks, 6 months, and 9 months post-LLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inadequate nutritional intake and undernutrition are alarmingly prevalent post-LLA. Living in a care facility and lower physical activity are determinants of undernutrition. Interventions to improve nutritional status, to potentially optimize clinical outcomes in the dysvascular major LLA population are highly needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0342726","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:34:17Z","timestamp":1790616857000},"page":"e0342726","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Undernutrition is alarmingly prevalent in the dysvascular major lower limb amputation population: A prospective cohort study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-097X","authenticated-orcid":true,"given":"Aniek M.","family":"Kolen","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["Groningen, The Netherlands"],"department":["Department of Rehabilitation Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie A.","family":"Krops","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["Groningen, The Netherlands"],"department":["Department of Rehabilitation Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri\u00ebt","family":"Jager-Wittenaar","sequence":"additional","affiliation":[{"name":"Hanze University of Applied Sciences","place":["Groningen, The Netherlands"],"department":["Research Group Healthy Ageing, Allied Health Care and Nursing"]},{"name":"Dietetics, Radboud University Medical Center","place":["Nijmegen, The Netherlands"],"department":["Department of Gastroenterology and Hepatology"]},{"name":"Vrije Universiteit Brussel","place":["Brussels, Belgium"],"department":["Department Physiotherapy, Human Physiology and Anatomy, Research Unit Experimental Anatomy, Faculty of Physical Education and Physiotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn L.","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen","place":["Groningen, The Netherlands"],"department":["Department of Surgery, Division of Vascular Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-8037","authenticated-orcid":true,"given":"B. Paul J. A.","family":"Keller","sequence":"additional","affiliation":[{"name":"Martini Hospital","place":["Groningen, The Netherlands"],"department":["Department of Vascular Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Oskam","sequence":"additional","affiliation":[{"name":"Isala Hospital","place":["Zwolle, The Netherlands"],"department":["Department of Surgery, Division of Vascular Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-0479","authenticated-orcid":true,"given":"Bastiaan P.","family":"Vierhout","sequence":"additional","affiliation":[{"name":"Treant Hospital","place":["Emmen, The Netherlands"],"department":["Department of Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul P. M.","family":"de Vries","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen","place":["Groningen, The Netherlands"],"department":["Department of Surgery, Division of Vascular Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens","family":"van Walraven","sequence":"additional","affiliation":[{"name":"Medical Center Leeuwarden","place":["Leeuwarden, The Netherlands"],"department":["Department of Vascular Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim P.","family":"Krijnen","sequence":"additional","affiliation":[{"name":"Hanze University of Applied Sciences","place":["Groningen, The Netherlands"],"department":["Research Group Healthy Ageing, Allied Health Care and Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rienk","family":"Dekker","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["Groningen, The Netherlands"],"department":["Department of Rehabilitation Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H. B.","family":"Geertzen","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["Groningen, The Netherlands"],"department":["Department of Rehabilitation Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"2","key":"pone.0342726.ref001","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejvs.2015.10.001","article-title":"Early Post-operative Mortality After Major Lower Limb Amputation: A Systematic Review of Population and Regional Based Studies","volume":"51","author":"JJ van Netten","year":"2016","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"pone.0342726.ref002","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.avsg.2016.12.015","article-title":"A Meta-analysis of Long-term Mortality and Associated Risk Factors following Lower Extremity Amputation","volume":"42","author":"JR Stern","year":"2017","journal-title":"Ann Vasc Surg"},{"issue":"2","key":"pone.0342726.ref003","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10016-006-9009-z","article-title":"Factors affecting perioperative mortality and wound-related complications following major lower extremity amputations","volume":"20","author":"PA Stone","year":"2006","journal-title":"Ann Vasc Surg"},{"issue":"5","key":"pone.0342726.ref004","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jvs.2011.04.048","article-title":"Predictors of wound complications following major amputation for critical limb ischemia","volume":"54","author":"R Hasanadka","year":"2011","journal-title":"J Vasc Surg"},{"issue":"1","key":"pone.0342726.ref005","doi-asserted-by":"crossref","first-page":"43717","DOI":"10.33137\/cpoj.v8i1.43717","article-title":"Wound management, healing, and early prosthetic rehabilitation: Part 3 - A scoping review of chemical biomarkers","volume":"8","author":"H Williams-Reid","year":"2025","journal-title":"Can Prosthet Orthot J"},{"issue":"8","key":"pone.0342726.ref006","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2340\/16501977-0393","article-title":"Predicting walking ability following lower limb amputation: a systematic review of the literature","volume":"41","author":"K Sansam","year":"2009","journal-title":"J Rehabil Med"},{"issue":"11","key":"pone.0342726.ref007","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3109\/09638288.2010.514646","article-title":"A systematic literature review of quality of life in lower limb amputees","volume":"33","author":"R Sinha","year":"2011","journal-title":"Disabil Rehabil"},{"key":"pone.0342726.ref008","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2340\/16501977-1146","article-title":"Change in health-related quality of life in the first 18 months after lower limb amputation","volume":"45","author":"L Fortington","year":"2013","journal-title":"J Rehabil Med"},{"key":"pone.0342726.ref009","article-title":"What is hidden behind amputation? Quanti-qualitative systematic review on psychological adjustment and quality of life in lower limb amputees for non-traumatic reasons","author":"L Calabrese","year":"2023","journal-title":"Healthcare"},{"issue":"1","key":"pone.0342726.ref010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clnu.2016.09.004","article-title":"ESPEN guidelines on definitions and terminology of clinical nutrition","volume":"36","author":"T Cederholm","year":"2017","journal-title":"Clin Nutr"},{"issue":"2","key":"pone.0342726.ref011","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/09638288.2022.2164363","article-title":"A scoping review on nutritional intake and nutritional status in people with a major dysvascular lower limb amputation","volume":"46","author":"AM Kolen","year":"2024","journal-title":"Disabil Rehabil"},{"key":"pone.0342726.ref012","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.avsg.2023.09.096","article-title":"Perceptions, Experiences, Barriers and Facilitators Regarding Nutritional Intake of Patients with Chronic Limb Threatening Ischemia: A Qualitative Study","volume":"99","author":"AM Kolen","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"pone.0342726.ref013","doi-asserted-by":"crossref","DOI":"10.1111\/jocn.14192","article-title":"Perceptions and experiences of nutritional care following the overwhelming experience of lower extremity amputation: A qualitative study","volume":"27","author":"PS Jensen","year":"2018","journal-title":"J Clin Nurs"},{"issue":"16","key":"pone.0342726.ref014","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1080\/09638288.2024.2439008","article-title":"Nutritional intake in people who have undergone a major dysvascular lower limb amputation: a qualitative study on perceptions, experiences, barriers and facilitators","volume":"47","author":"AM Kolen","year":"2025","journal-title":"Disabil Rehabil"},{"issue":"8","key":"pone.0342726.ref015","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-147-8-200710160-00010-w1","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"147","author":"JP Vandenbroucke","year":"2007","journal-title":"Ann Intern Med"},{"issue":"2","key":"pone.0342726.ref016","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"pone.0342726.ref017","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"PA Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"pone.0342726.ref018","volume-title":"Portiegrootteboek","author":"T Peersman","year":"2017"},{"issue":"3","key":"pone.0342726.ref019","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.clnu.2017.02.013","article-title":"ESPEN guideline: Clinical nutrition in surgery","volume":"36","author":"A Weimann","year":"2017","journal-title":"Clin Nutr"},{"issue":"4","key":"pone.0342726.ref020","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.clnu.2009.04.002","article-title":"ESPEN Guidelines on Parenteral Nutrition: surgery","volume":"28","author":"M Braga","year":"2009","journal-title":"Clin Nutr"},{"issue":"8","key":"pone.0342726.ref021","article-title":"A Scoping Review of Physical Activity in People With Lower-Limb Loss: 10,000 Steps Per Day?","volume":"101","author":"CK Wong","year":"2021","journal-title":"Phys Ther"},{"issue":"2","key":"pone.0342726.ref022","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/10833196.2017.1412788","article-title":"Physical activity in individuals with lower extremity amputations: a narrative review","volume":"23","author":"ME Pepin","year":"2017","journal-title":"Physical Therapy Reviews"},{"issue":"6","key":"pone.0342726.ref023","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.clnu.2014.04.007","article-title":"Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group","volume":"33","author":"NEP Deutz","year":"2014","journal-title":"Clin Nutr"},{"issue":"8","key":"pone.0342726.ref024","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jamda.2013.05.021","article-title":"Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group","volume":"14","author":"J Bauer","year":"2013","journal-title":"J Am Med Dir Assoc"},{"issue":"8","key":"pone.0342726.ref025","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ejcn.2016.52","article-title":"The 2015 Dutch food-based dietary guidelines","volume":"70","author":"D Kromhout","year":"2016","journal-title":"Eur J Clin Nutr"},{"issue":"13","key":"pone.0342726.ref026","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1017\/S136898001700091X","article-title":"Development and evaluation of the Dutch Healthy Diet index 2015","volume":"20","author":"M Looman","year":"2017","journal-title":"Public Health Nutr"},{"issue":"5","key":"pone.0342726.ref027","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ageing\/28.5.469","article-title":"Energy intake and micronutrient intake in elderly Europeans: seeking the minimum requirement in the SENECA study","volume":"28","author":"CP de Groot","year":"1999","journal-title":"Age Ageing"},{"issue":"6","key":"pone.0342726.ref028","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/NCC.0000000000000505","article-title":"Translation and Cultural Adaptation of the Scored Patient-Generated Subjective Global Assessment: An Interdisciplinary Nutritional Instrument Appropriate for Dutch Cancer Patients","volume":"41","author":"MJ Sealy","year":"2018","journal-title":"Cancer Nurs"},{"issue":"5","key":"pone.0342726.ref029","first-page":"322","article-title":"Assessing nutritional status in cancer: role of the Patient-Generated Subjective Global Assessment","volume":"20","author":"H Jager-Wittenaar","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"pone.0342726.ref030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1115\/1.1590359","article-title":"Analysis of body segment parameter differences between four human populations and the estimation errors of four popular mathematical models","volume":"125","author":"JL Durkin","year":"2003","journal-title":"J Biomech Eng"},{"issue":"15","key":"pone.0342726.ref031","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3109\/09638288.2012.726690","article-title":"Body mass index patterns following dysvascular lower extremity amputation","volume":"35","author":"DE Rosenberg","year":"2013","journal-title":"Disabil Rehabil"},{"issue":"1","key":"pone.0342726.ref032","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1186\/s12891-021-04646-2","article-title":"The association between body mass index and skin problems in persons with a lower limb amputation: an observational study","volume":"22","author":"TS Mollee","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"pone.0342726.ref033","doi-asserted-by":"crossref","first-page":"111072","DOI":"10.1016\/j.nut.2020.111072","article-title":"Prevalence of malnutrition comparing NRS2002, MUST, and PG-SGA with the GLIM criteria in adults with cancer: A multi-center study","volume":"83","author":"Z Zhang","year":"2021","journal-title":"Nutrition"},{"issue":"2","key":"pone.0342726.ref034","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/01635581.2021.1910320","article-title":"Malnutrition and the Survival of Cervical Cancer Patients: A Prospective Cohort Study Using the PG-SGA Tool","volume":"74","author":"TG Argefa","year":"2022","journal-title":"Nutr Cancer"},{"key":"pone.0342726.ref035","doi-asserted-by":"crossref","first-page":"110814","DOI":"10.1016\/j.nut.2020.110814","article-title":"High prevalence of malnutrition both on hospital admission and predischarge","volume":"77","author":"IMY van Vliet","year":"2020","journal-title":"Nutrition"},{"issue":"6","key":"pone.0342726.ref036","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/ncp.10476","article-title":"Nutrition Status and Health-Related Quality of Life Among Outpatients With Advanced Head and Neck Cancer","volume":"35","author":"U Mulasi","year":"2020","journal-title":"Nutr Clin Pract"},{"issue":"4","key":"pone.0342726.ref037","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","journal-title":"Age and Ageing"},{"issue":"1","key":"pone.0342726.ref038","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcsm.12383","article-title":"GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community","volume":"10","author":"T Cederholm","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"pone.0342726.ref039","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"ME Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"pone.0342726.ref040","unstructured":"Netherlands HCot. Dutch physical activity guidelines 2017. 2017."},{"issue":"8","key":"pone.0342726.ref041","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1080\/02640414.2020.1850983","article-title":"Test-retest reliability and concurrent validity of the Adapted Short QUestionnaire to ASsess Health-enhancing physical activity (Adapted-SQUASH) in adults with disabilities","volume":"39","author":"BL Seves","year":"2021","journal-title":"J Sports Sci"},{"key":"pone.0342726.ref042","volume-title":"R language and environment for statistical computing","author":"RC Team","year":"2020"},{"key":"pone.0342726.ref043","article-title":"Fitting linear mixed-effects models using lme4","author":"D Bates","year":"2014","journal-title":"arXiv preprint"},{"key":"pone.0342726.ref044","volume-title":"Package \u2018multcomp\u2019. Simultaneous inference in general parametric models","author":"T Hothorn","year":"2016"},{"issue":"3","key":"pone.0342726.ref045","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"T Hothorn","year":"2008","journal-title":"Biom J"},{"issue":"9","key":"pone.0342726.ref046","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jclinepi.2013.03.017","article-title":"Multiple imputation of missing values was not necessary before performing a longitudinal mixed-model analysis","volume":"66","author":"J Twisk","year":"2013","journal-title":"J Clin Epidemiol"},{"issue":"6","key":"pone.0342726.ref047","first-page":"675","article-title":"Nutrition as a prognostic indicator in amputations. A prospective study of 47 cases","volume":"63","author":"NW Pedersen","year":"1992","journal-title":"Acta Orthop Scand"},{"issue":"2","key":"pone.0342726.ref048","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s002640050130","article-title":"Improved wound healing in transtibial amputees receiving supplementary nutrition","volume":"21","author":"M Eneroth","year":"1997","journal-title":"Int Orthop"},{"key":"pone.0342726.ref049","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.avsg.2021.07.023","article-title":"Acceptance of illness, quality of life and nutritional status of patients after lower limb amputation due to diabetes mellitus","volume":"79","author":"J Juzwiszyn","year":"2022","journal-title":"Ann Vasc Surg"},{"issue":"5","key":"pone.0342726.ref050","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1177\/0148607115625638","article-title":"Association Between Malnutrition and Clinical Outcomes in the Intensive Care Unit: A Systematic Review [Formula: see text]","volume":"41","author":"CCH Lew","year":"2017","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"6","key":"pone.0342726.ref051","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/jpen.2211","article-title":"A systematic review of the malnutrition prevalence in hospitalized hip fracture patients and its associated outcomes","volume":"45","author":"MXE Foo","year":"2021","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"2","key":"pone.0342726.ref052","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.arr.2012.11.003","article-title":"Malnutrition and quality of life in older people: a systematic review and meta-analysis","volume":"12","author":"S Rasheed","year":"2013","journal-title":"Ageing Res Rev"},{"key":"pone.0342726.ref053","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.avsg.2024.09.052","article-title":"Perceptions, Barriers and Facilitators Regarding Nutritional Care for Patients with Chronic Limb Threatening Ischemia: A Focus Group Study Among Healthcare Professionals","volume":"110","author":"AM Kolen","year":"2025","journal-title":"Ann Vasc Surg"},{"issue":"12","key":"pone.0342726.ref054","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.jand.2017.06.364","article-title":"Effectiveness of Dietetic Consultations in Primary Health Care: A Systematic Review of Randomized Controlled Trials","volume":"117","author":"LJ Mitchell","year":"2017","journal-title":"J Acad Nutr Diet"},{"issue":"4","key":"pone.0342726.ref055","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.clnu.2018.07.023","article-title":"Effectiveness of nutritional interventions in older adults at risk of malnutrition across different health care settings: Pooled analyses of individual participant data from nine randomized controlled trials","volume":"38","author":"I Reinders","year":"2019","journal-title":"Clin Nutr"},{"issue":"3","key":"pone.0342726.ref056","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3945\/an.115.011254","article-title":"Risk Factors for Malnutrition in Older Adults: A Systematic Review of the Literature Based on Longitudinal Data","volume":"7","author":"NC F\u00e1varo-Moreira","year":"2016","journal-title":"Adv Nutr"},{"issue":"6","key":"pone.0342726.ref057","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.clnu.2018.12.007","article-title":"Potentially modifiable determinants of malnutrition in older adults: A systematic review","volume":"38","author":"M O\u2019Keeffe","year":"2019","journal-title":"Clinical Nutrition"},{"issue":"4","key":"pone.0342726.ref058","doi-asserted-by":"crossref","DOI":"10.1002\/ncp.10785","article-title":"Systematic review of clinicians\u2019 knowledge, attitudes, and beliefs about nutrition in intensive care","volume":"37","author":"GC Lyons","year":"2022","journal-title":"Nutrition in Clinical Practice"},{"issue":"1","key":"pone.0342726.ref059","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/fampra\/cmaa091","article-title":"Malnutrition in older adults: how interprofessional teams see it? A systematic review of the qualitative research","volume":"38","author":"F Mawardi","year":"2021","journal-title":"Fam Pract"},{"issue":"1","key":"pone.0342726.ref060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1747-0080.2010.01495.x","article-title":"Everyone\u2019s problem but nobody\u2019s job: Staff perceptions and explanations for poor nutritional intake in older medical patients","volume":"68","author":"LJ Ross","year":"2011","journal-title":"Nutrition & Dietetics"},{"key":"pone.0342726.ref061","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/jocn.14020","article-title":"Stuck in tradition-A qualitative study on barriers for implementation of evidence-based nutritional care perceived by nursing staff","volume":"27","author":"MB O Connell","year":"2018","journal-title":"J Clin Nurs"},{"key":"pone.0342726.ref062","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.maturitas.2016.05.016","article-title":"Exercise prescription for the older population: The interactions between physical activity, sedentary time, and adequate nutrition in maintaining musculoskeletal health","volume":"93","author":"BJ Shad","year":"2016","journal-title":"Maturitas"},{"issue":"3","key":"pone.0342726.ref063","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.amjsurg.2017.11.038","article-title":"Risk for malnutrition in patients prior to vascular surgery","volume":"216","author":"LT Beek","year":"2018","journal-title":"Am J Surg"},{"issue":"4","key":"pone.0342726.ref064","first-page":"342","article-title":"A hidden problem: peripheral artery disease in women","volume":"9","author":"MM Kavurma","year":"2023","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"3","key":"pone.0342726.ref065","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.carrev.2019.05.026","article-title":"Peripheral Arterial Disease in Women: The Gender Effect","volume":"21","author":"T Patel","year":"2020","journal-title":"Cardiovasc Revasc Med"},{"key":"pone.0342726.ref066","doi-asserted-by":"crossref","DOI":"10.1053\/j.semvascsurg.2022.04.006","article-title":"Women\u2019s vascular health: peripheral artery disease in female patients","volume-title":"Seminars in Vascular Surgery","author":"S Kim","year":"2022"},{"issue":"6","key":"pone.0342726.ref067","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/PHM.0000000000000055","article-title":"Prevalence and 1-year course of alcohol misuse and smoking in persons with lower extremity amputation as a result of peripheral arterial disease","volume":"93","author":"AP Turner","year":"2014","journal-title":"Am J Phys Med Rehabil"},{"issue":"2","key":"pone.0342726.ref068","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/0309364616650079","article-title":"Limitations of body mass index for counseling individuals with unilateral lower extremity amputation","volume":"41","author":"AP Frost","year":"2017","journal-title":"Prosthet Orthot Int"},{"key":"pone.0342726.ref069","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fendo.2019.00850","article-title":"Validity of Dietary Assessment Methods When Compared to the Method of Doubly Labeled Water: A Systematic Review in Adults","volume":"10","author":"TL Burrows","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"14","key":"pone.0342726.ref070","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1177\/1359105317714318","article-title":"People with a body mass index \u2a7e30 under-report their dietary intake: A systematic review","volume":"24","author":"H Wehling","year":"2019","journal-title":"J Health Psychol"},{"issue":"5","key":"pone.0342726.ref071","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1053\/j.jfas.2018.12.038","article-title":"Patient Health Literacy and Diabetic Foot Amputations","volume":"58","author":"K Hadden","year":"2019","journal-title":"J Foot Ankle Surg"},{"issue":"6","key":"pone.0342726.ref072","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ejvs.2024.03.040","article-title":"Health Literacy and Disease Knowledge of Patients With Peripheral Arterial Disease or Abdominal Aortic Aneurysm: A Scoping Review","volume":"67","author":"GL van Leeuwen","year":"2024","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"25","key":"pone.0342726.ref073","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.3109\/09638288.2012.677936","article-title":"How \u201cpreventable\u201d are lower extremity amputations? A qualitative study of patient perceptions of precipitating factors","volume":"34","author":"J Feinglass","year":"2012","journal-title":"Disabil Rehabil"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:34:29Z","timestamp":1790616869000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342726"}},"subtitle":[],"editor":[{"given":"Dev Ram","family":"Sunuwar","sequence":"first","affiliation":[{"name":"University of Michigan","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":73,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0342726","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}