{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:10:09Z","timestamp":1779937809860,"version":"3.53.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["Departamento de Ciencia, Universidad y Sociedad del Conocimiento, reearch group S31_23R"],"award-info":[{"award-number":["Departamento de Ciencia, Universidad y Sociedad del Conocimiento, reearch group S31_23R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["Subvenciones para el desarrollo de proyectos de I+D+i en l\u00edneas prioritarias y de car\u00e1cter multidisciplinar para el periodo 2024-2026, PROY_S22_24"],"award-info":[{"award-number":["Subvenciones para el desarrollo de proyectos de I+D+i en l\u00edneas prioritarias y de car\u00e1cter multidisciplinar para el periodo 2024-2026, PROY_S22_24"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long COVID-19 is a medical condition associated with persistent physical, cognitive, and emotional symptoms. Despite its significant impact, there are still few psychological interventions\u2014especially with transdiagnostic approaches\u2014 that have been rigorously tested in this population. The aim of the present protocol is to describe a randomized controlled trial to examine the effectiveness and acceptability of the online, group-delivered Unified Protocol (UP) for improving emotional, and cognitive outcomes in adults with long COVID-19. We expect greater improvements in emotional and cognitive outcomes for the UP group compared to controls. Additionally, exploratory analyses will assess changes in neurocognitive performance and hair cortisol\/cortisone levels as potential correlates of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>90 individuals diagnosed with long COVID-19 will be randomized to an experimental group or a waiting-list control group (1:1 ratio). Participants in the experimental group will receive the UP across 12 online group sessions. Longitudinal assessments (pre-treatment, post-treatment and 3, 6 and 12 months follow-ups) will include psychological (e.g., anxiety and depressive symptoms) and cognitive outcomes (e.g., memory failures). Participants in the experimental group will also complete neuropsychological tests and will provide hair samples for the assessment of cortisol\/cortisone levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Data analyses<\/jats:title>\n                    <jats:p>Baseline characteristics will be described using descriptive statistics, and linear mixed-effects models will evaluate the effects of time, group, and their interaction on psychological and cognitive outcomes. Neuropsychological performance and hair cortisol levels will be analyzed over time in the experimental group. Associations between cortisol and psychological or cognitive measures will be explored through correlational analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We expect positive outcomes after the intervention in acceptability and in emotional symptoms and cognitive complaints in individuals living with long COVID-19, the maintenance of the benefits in all follow-ups, and statistically significant changes in favor of the UP condition in comparison with the waiting-list control group. If effective, the UP could provide an accessible and evidence-based psychological treatment for this population, improving the quality of healthcare to individuals with long COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      clinicatrials.gov (registration identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06928480\" xlink:type=\"simple\">NCT06928480<\/jats:ext-link>\n                      ; May 22, 2025).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0342908","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:30:40Z","timestamp":1771353040000},"page":"e0342908","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and acceptability of the unified protocol for the transdiagnostic treatment of emotional disorders in people with long COVID-19: Study protocol for a randomized controlled trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-8115","authenticated-orcid":true,"given":"Ver\u00f3nica","family":"Mart\u00ednez-Borba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s E.","family":"Rodr\u00edguez-M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Garc\u00e9s-Arilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-1207","authenticated-orcid":true,"given":"\u00d3scar","family":"Peris-Baquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Vicenta","family":"Navarro-Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"del Corral-Beamonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7293-318X","authenticated-orcid":true,"given":"Jorge","family":"Osma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"pone.0342908.ref001","author":"World Health Orgnization [WHO]","year":"2020"},{"key":"pone.0342908.ref002","author":"World Health Orgnization [WHO]","year":"2021"},{"key":"pone.0342908.ref003","author":"World Health Orgnization [WHO]","year":"2025"},{"issue":"1","key":"pone.0342908.ref004","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13643-023-02250-0","article-title":"A systematic review and meta-analysis of long COVID symptoms","volume":"12","author":"A Natarajan","year":"2023","journal-title":"Syst Rev"},{"key":"pone.0342908.ref005","author":"European Comission","year":"2023"},{"key":"pone.0342908.ref006","author":"Center for Disease Control and Prevention","year":"2025"},{"key":"pone.0342908.ref007","author":"National Institute for Health and Clinical Excellence [NICE]","year":"2024"},{"issue":"1","key":"pone.0342908.ref008","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12888-023-05481-6","article-title":"The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis","volume":"24","author":"N Seighali","year":"2024","journal-title":"BMC Psychiatry"},{"key":"pone.0342908.ref009","doi-asserted-by":"crossref","first-page":"1305463","DOI":"10.3389\/fpubh.2023.1305463","article-title":"Guiding future research on psychological interventions in people with COVID-19 and post COVID syndrome and comorbid emotional disorders based on a systematic review","volume":"11","author":"V Mart\u00ednez-Borba","year":"2024","journal-title":"Front Public Health"},{"issue":"1","key":"pone.0342908.ref010","doi-asserted-by":"crossref","DOI":"10.1136\/bmjment-2024-301133","article-title":"Systematic review of interventions for mental health, cognition and psychological well-being in long COVID","volume":"27","author":"LD Hawke","year":"2024","journal-title":"BMJ Ment Health"},{"issue":"3","key":"pone.0342908.ref011","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1177\/17423953221113605","article-title":"Patient-led integrated cognitive behavioural therapy for management of long COVID with comorbid depression and anxiety in primary care - A case study","volume":"18","author":"L Skilbeck","year":"2022","journal-title":"Chronic Illn"},{"issue":"6","key":"pone.0342908.ref012","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/jamapsychiatry.2025.0482","article-title":"Cognitive Behavior Therapy for Mental Disorders in Adults: A Unified Series of Meta-Analyses","volume":"82","author":"P Cuijpers","year":"2025","journal-title":"JAMA Psychiatry"},{"key":"pone.0342908.ref013","doi-asserted-by":"crossref","first-page":"102353","DOI":"10.1016\/j.cpr.2023.102353","article-title":"Cognitive behavioral therapies for depression and anxiety in people with chronic disease: A systematic review and meta-analysis","volume":"106","author":"AJ Scott","year":"2023","journal-title":"Clin Psychol Rev"},{"key":"pone.0342908.ref014","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/da.23113","article-title":"Co\u2010morbidity between mood and anxiety disorders: A systematic review and meta\u2010analysis","volume":"38","author":"S Saha","year":"2021","journal-title":"Depress Anxiety"},{"key":"pone.0342908.ref015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0005-7894(04)80036-4","article-title":"Toward a unified treatment for emotional disorders","volume":"35","author":"D Barlow","year":"2004","journal-title":"Behav Ther"},{"issue":"9","key":"pone.0342908.ref016","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/jamapsychiatry.2017.2164","article-title":"The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders Compared With Diagnosis-Specific Protocols for Anxiety Disorders: A Randomized Clinical Trial","volume":"74","author":"DH Barlow","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"pone.0342908.ref017","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000516380","article-title":"Transdiagnostic versus Diagnosis-Specific Group Cognitive Behavioral Therapy for Anxiety Disorders and Depression: A Randomized Controlled Trial","volume":"91","author":"N Reinholt","year":"2022","journal-title":"Psychother Psychosom"},{"issue":"10","key":"pone.0342908.ref018","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.3390\/ijerph18105077","article-title":"Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Medical Conditions: A Systematic Review","volume":"18","author":"J Osma","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"pone.0342908.ref019","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cpr.2015.06.002","article-title":"Systematic review and meta-analysis of transdiagnostic psychological treatments for anxiety and depressive disorders in adulthood","volume":"40","author":"JM Newby","year":"2015","journal-title":"Clin Psychol Rev"},{"key":"pone.0342908.ref020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.genhosppsych.2024.02.009","article-title":"Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis","volume":"88","author":"C van der Feltz-Cornelis","year":"2024","journal-title":"Gen Hosp Psychiatry"},{"key":"pone.0342908.ref021","doi-asserted-by":"crossref","first-page":"1076743","DOI":"10.3389\/fpsyg.2023.1076743","article-title":"Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID","volume":"14","author":"T Llana","year":"2023","journal-title":"Front Psychol"},{"key":"pone.0342908.ref022","article-title":"SPIRIT 2025 statement: updated guideline for protocols of randomised trials","volume":"389","author":"A-W Chan","year":"2025","journal-title":"BMJ"},{"issue":"2","key":"pone.0342908.ref023","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"issue":"3","key":"pone.0342908.ref024","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1037\/a0036216","article-title":"Development and validation of the Overall Depression Severity and Impairment Scale","volume":"26","author":"KH Bentley","year":"2014","journal-title":"Psychol Assess"},{"key":"pone.0342908.ref025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jad.2019.03.063","article-title":"Psychometric properties and validation of the Spanish versions of the overall anxiety and depression severity and impairment scales","volume":"252","author":"J Osma","year":"2019","journal-title":"J Affect Disord"},{"issue":"4","key":"pone.0342908.ref026","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/da.20182","article-title":"Development and validation of an Overall Anxiety Severity And Impairment Scale (OASIS)","volume":"23","author":"SB Norman","year":"2006","journal-title":"Depress Anxiety"},{"key":"pone.0342908.ref027","volume-title":"Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5)- Adult and Lifetime Version: Clinician Manual","author":"T Brown","year":"2014"},{"issue":"1","key":"pone.0342908.ref028","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/arclin\/acae042","article-title":"Neurocognitive Impairment in Long COVID: A Systematic Review","volume":"40","author":"E Panagea","year":"2025","journal-title":"Arch Clin Neuropsychol"},{"issue":"8","key":"pone.0342908.ref029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0329595","article-title":"Preliminary feasibility and clinical utility of the Unified Protocol for the transdiagnostic treatment of emotional disorders in people with long COVID-19 condition: A single case pilot study","volume":"20","author":"V Mart\u00ednez-Borba","year":"2025","journal-title":"PLoS One"},{"issue":"2","key":"pone.0342908.ref030","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/01688638408401204","article-title":"Memory failures in everyday life following severe head injury","volume":"6","author":"A Sunderland","year":"1984","journal-title":"J Clin Neuropsychol"},{"issue":"3","key":"pone.0342908.ref031","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.5209\/rev_SJOP.2012.v15.n3.39426","article-title":"The Memory Failures of Everyday (MFE) test: normative data in adults","volume":"15","author":"P Montejo Carrasco","year":"2012","journal-title":"Span J Psychol"},{"issue":"1","key":"pone.0342908.ref032","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1037\/pas0000649","article-title":"The Multidimensional Emotional Disorder Inventory (MEDI): Assessing transdiagnostic dimensions to validate a profile approach to emotional disorder classification","volume":"31","author":"AJ Rosellini","year":"2019","journal-title":"Psychol Assess"},{"key":"pone.0342908.ref033","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jad.2022.09.140","article-title":"Multidimensional emotional disorders inventory: Reliability and validity in a Spanish clinical sample","volume":"320","author":"J Osma","year":"2023","journal-title":"J Affect Disord"},{"key":"pone.0342908.ref034","first-page":"139","article-title":"The Spanish version of the Difficulties in Emotion Regulation Scale","volume":"19","author":"G Herv\u00e1s","year":"2008","journal-title":"Clin y Salud"},{"issue":"1","key":"pone.0342908.ref035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/B:JOBA.0000007455.08539.94","article-title":"Multidimensional Assessment of Emotion Regulation and Dysregulation: Development, Factor Structure, and Initial Validation of the Difficulties in Emotion Regulation Scale","volume":"26","author":"KL Gratz","year":"2004","journal-title":"J Psychopathol Behav Assess"},{"issue":"1","key":"pone.0342908.ref036","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0168-8510(96)00822-6","article-title":"EuroQol: the current state of play","volume":"37","author":"R Brooks","year":"1996","journal-title":"Health Policy"},{"issue":"4","key":"pone.0342908.ref037","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/A:1008894502042","article-title":"Using the EuroQoI 5-D in the Catalan general population: feasibility and construct validity","volume":"7","author":"X Badia","year":"1998","journal-title":"Qual Life Res"},{"issue":"3","key":"pone.0342908.ref038","doi-asserted-by":"crossref","first-page":"421","DOI":"10.7334\/psicothema2016.239","article-title":"Psychometric properties of the spanish version of The Distress Tolerance Scale and its relationship with personality and psychopathological symptoms","volume":"29","author":"B Sand\u00edn","year":"2017","journal-title":"Psicothema"},{"key":"pone.0342908.ref039","first-page":"195","article-title":"Versi\u00f3n espa\u00f1ola de la escala de estr\u00e9s percibido (PSS-14): estudio psicom\u00e9trico en una muestra VIH+","volume":"7","author":"E Remor","year":"2001","journal-title":"Ansiedad y estr\u00e9s"},{"issue":"4","key":"pone.0342908.ref040","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A Global Measure of Perceived Stress","volume":"24","author":"S Cohen","year":"1983","journal-title":"J Health Soc Behav"},{"issue":"3","key":"pone.0342908.ref041","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0149-7189(79)90094-6","article-title":"Assessment of client\/patient satisfaction: development of a general scale","volume":"2","author":"DL Larsen","year":"1979","journal-title":"Eval Program Plann"},{"issue":"4","key":"pone.0342908.ref042","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"ZS Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"pone.0342908.ref043","volume-title":"Wechsler Memory Scale (3rd edition)","author":"D Wechsler","year":"1997"},{"key":"pone.0342908.ref044","volume-title":"Wechsler Adult Intelligence Scale (4th edition)","author":"D Wechsler","year":"2008"},{"key":"pone.0342908.ref045","volume-title":"Unified protocol for transdiagnostic treatment of emotional disorders: Therapist guide","author":"D Barlow","year":"2018","edition":"2"},{"issue":"1","key":"pone.0342908.ref046","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Usinglme4","volume":"67","author":"D Bates","year":"2015","journal-title":"J Stat Soft"},{"key":"pone.0342908.ref047","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"pone.0342908.ref048","volume-title":"IBM SPSS Statistics for Windows, Version 25.0","author":"IBM Corp","year":"2017"},{"issue":"1","key":"pone.0342908.ref049","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1186\/s13063-022-06731-w","article-title":"Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivors for cognitive impairments: study protocol for a randomized controlled trial","volume":"23","author":"F Garc\u00eda-Torres","year":"2022","journal-title":"Trials"},{"issue":"1","key":"pone.0342908.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10072-024-07854-5","article-title":"Neurological, psychological, psychosocial complications of long-COVID and their management","volume":"46","author":"SN Narayanan","year":"2025","journal-title":"Neurol Sci"},{"issue":"2","key":"pone.0342908.ref051","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1521-690X(02)00101-X","article-title":"HPA axis and memory","volume":"17","author":"OT Wolf","year":"2003","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"pone.0342908.ref052","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1186\/s12889-024-18267-6","article-title":"An exploration of the experiences and self-generated strategies used when navigating everyday life with Long Covid","volume":"24","author":"FJ Leggat","year":"2024","journal-title":"BMC Public Health"},{"key":"pone.0342908.ref053","doi-asserted-by":"crossref","first-page":"101751","DOI":"10.1016\/j.cpr.2019.101751","article-title":"A systematic review and meta-analysis of the Unified Protocol as a transdiagnostic emotion regulation based intervention","volume":"72","author":"N Sakiris","year":"2019","journal-title":"Clin Psychol Rev"},{"issue":"6","key":"pone.0342908.ref054","article-title":"Benefits and challenges of cancer peer support groups: A systematic review of qualitative studies","volume":"31","author":"M Jablotschkin","year":"2022","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"15","key":"pone.0342908.ref055","doi-asserted-by":"crossref","first-page":"9076","DOI":"10.3390\/ijerph19159076","article-title":"Social Life of Females with Persistent COVID-19 Symptoms: A Qualitative Study","volume":"19","author":"A Aghaei","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"pone.0342908.ref056","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12916-025-04335-0","article-title":"\u201cHave you considered that it could be burnout?\u201d-psychologization and stigmatization of self-reported long COVID or post-COVID-19 vaccination syndrome","volume":"23","author":"R B\u00fcchner","year":"2025","journal-title":"BMC Med"},{"issue":"1","key":"pone.0342908.ref057","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12888-022-04497-8","article-title":"The emotional well-being of Long COVID patients in relation to their symptoms, social support and stigmatization in social and health services: a qualitative study","volume":"23","author":"M Samper-Pardo","year":"2023","journal-title":"BMC Psychiatry"},{"issue":"10","key":"pone.0342908.ref058","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0292630","article-title":"The lived experience of long COVID: A qualitative study of mental health, quality of life, and coping","volume":"18","author":"CE Kennelly","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"pone.0342908.ref059","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281884","article-title":"Living with \u201clong COVID\u201d: A systematic review and meta-synthesis of qualitative evidence","volume":"18","author":"MM Hossain","year":"2023","journal-title":"PLoS One"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:30:49Z","timestamp":1771353049000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342908"}},"subtitle":[],"editor":[{"given":"Annesha","family":"Sil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":59,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0342908","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]}}}