{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T19:25:39Z","timestamp":1772479539181,"version":"3.50.1"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maternal hyperuricemia is a potential biomarker of adverse pregnancy outcomes, but evidence among normotensive women in low- and middle-income countries is limited. We aimed to assess the association between elevated maternal serum uric acid (SUA) levels and adverse neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective cohort study at Jinja Regional Referral Hospital, Uganda, from 1\n                      <jats:sup>st<\/jats:sup>\n                      October 2024\u20131\n                      <jats:sup>st<\/jats:sup>\n                      February 2025, enrolling 352 normotensive women in latent labor. SUA was measured using gestational-age\u2013specific cutoffs, classifying women as hyperuricemic or normouricemic. Outcomes included preterm birth, small-for-gestational-age (SGA) birth, stillbirth, and low Apgar score. Poisson regression with robust standard errors estimated adjusted relative risks (aRR) and 95% confidence intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adverse neonatal outcomes occurred in 37.5% of participants. Hyperuricemic women had significantly higher composite risk (62.5% vs. 12.5%; aRR\u2009=\u20094.32, 95% CI 2.92\u20136.39). Hyperuricemia independently predicted preterm birth (aRR\u2009=\u20093.63, 95% CI 1.70\u20137.72), SGA (aRR\u2009=\u20092.80, 95% CI 1.61\u20134.86), and stillbirth (aRR\u2009=\u20095.00, 95% CI 1.47\u201316.99). Maternal age\u2009\u2265\u200940 years, low education,\u2009&lt;\u20094 antenatal visits, previous preterm birth, previous stillbirth, and obesity were also associated with adverse outcomes.\n                      <jats:bold>Conclusions.<\/jats:bold>\n                    <\/jats:p>\n                    <jats:p>Maternal hyperuricemia is a strong predictor of preterm birth, SGA, and stillbirth. Routine SUA screening during antenatal care, combined with closer monitoring of high-risk women, could help improve neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0342913","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T18:23:44Z","timestamp":1772475824000},"page":"e0342913","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal hyperuricemia and adverse neonatal outcomes in normotensive pregnancies: Evidence from a prospective cohort study in Eastern Uganda"],"prefix":"10.1371","volume":"21","author":[{"given":"Hassan Abdullahi","family":"Hafsa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Pascaline","family":"Sabine Ishimwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"Kasujja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Okot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawda Abdikarim","family":"Sheikh Isse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein Mire","family":"Hamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamud Mohamed","family":"Sadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramlo Abdi","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam Abdrahim","family":"Suliman Ebaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Okello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Kiswezi","family":"Kazigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Nteziyaremye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Bwaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-5733","authenticated-orcid":true,"given":"Theoneste","family":"Hakizimana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"issue":"9463","key":"pone.0342913.ref001","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0140-6736(05)71088-6","article-title":"Evidence-based, cost-effective interventions: how many newborn babies can we save?","volume":"365","author":"GL Darmstadt","year":"2005","journal-title":"Lancet"},{"key":"pone.0342913.ref002","unstructured":"Save the children. 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