{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:33:43Z","timestamp":1790620423850,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"School-level Project of Shanxi University of Traditional Chinese Medicine","award":["2024PY-JL-24-01"],"award-info":[{"award-number":["2024PY-JL-24-01"]}]},{"name":"Basic Research Programme of Shanxi Province","award":["202203021221288"],"award-info":[{"award-number":["202203021221288"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The progression of Chronic gastritis seems to follow a pattern from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG) to cancer, so it is particularly important to block key targets in disease progression. A gene that synthesizes secreted phospholipase A2, attracted our attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study whether phospholipase A2 group 10 (PLA2G10) in epithelial cells promote the progression of CNAG to CAG through the transforming growth factor-\u03b2 (TGF-\u03b2) signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used RNA microarray and single-cell RNA sequencing datasets for bioinformatics analysis. The effects of PLA2G10 were verified by\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments. The\n                      <jats:italic>in vivo<\/jats:italic>\n                      experiments used SD rats to establish a CNAG model for PLA2G10 and TGF-\u03b2 intervention to observe the effects on gastric mucosal inflammation.\n                      <jats:italic>In vitro<\/jats:italic>\n                      experiments were conducted using human gastric mucosal epithelial cells (GES-1) for similar interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PLA2G10 inhibition led to the downregulation of TGF-\u03b2 expression and attenuated the inflammatory response of the gastric mucosa. And the blockade of TGF-\u03b2 signalling delayed the progression of CNAG to CAG, as evidenced by a reduction in inflammatory cell infiltration, a more regular cellular arrangement, and a reduction in collagen deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study shows that PLA2G10 plays a key role in the progression of chronic gastritis and highlights the important role played by the TGF-\u03b2 signalling pathway in this process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0343531","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:30:05Z","timestamp":1772649005000},"page":"e0343531","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased secreted PLA2 in epithelial cells promotes the 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