{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:01:50Z","timestamp":1776448910876,"version":"3.51.2"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, the optimal volume of pericapsular nerve group (PENG) block for analgesia after total hip arthroplasty (THA) has not been clarified. In this trial, we investigated whether a high-volume PENG block has a superior analgesic effect than a conventional PENG block for primary THA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients receiving primary THA under spinal anesthesia were enrolled and randomly divided into the high-volume PENG group (40 mL of 0.375% ropivacaine) and the conventional-volume PENG group (20 mL of 0.375% ropivacaine). Dexamethasone (5 mg) was added to the local anesthetic in both groups. A blinded researcher performed pain scores and lower limb sensory and motor block assessments at 3, 6, and 24 h after surgery. The time of first walking, time of first opioid consumption, total opioid consumption within 48 h, nerve block, opioid-related complications, and length of hospital stay were recorded. The primary outcome was the dynamic pain scores at 6 h post-surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-seven patients were included in the final analysis, among whom 18 were in the high-volume group and 19 in the conventional-volume group. There were no significant differences between the two groups in dynamic pain scores at 6h after surgery [median and interquartile range (p25, p75) 5(4,6) vs 4 (4,5)] and other secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high-volume PENG block is not superior to conventional-volume PENG block in improving post-operative analgesia in patients undergoing primary THA and does not increase the risk of quadriceps weakness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Chinese Clinical Trial Registry (ChiCTR,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\" xlink:type=\"simple\">https:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      ). Clinical trial registration number: ChiCTR2300077281.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0343615","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:25:44Z","timestamp":1776446744000},"page":"e0343615","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-versus conventional-volume pericapsular nerve group (PENG) block for total hip arthroplasty: A randomized, controlled trial"],"prefix":"10.1371","volume":"21","author":[{"given":"Qian-song","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-ming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong-mei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-8969","authenticated-orcid":true,"given":"Zhao-hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"issue":"8","key":"pone.0343615.ref001","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00198-023-06774-y","article-title":"Trends 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controlled trial determining efficacy of fascia iliaca compartment blocks in the immediate postoperative period","volume":"35","author":"K Bober","year":"2020","journal-title":"J Arthroplasty"},{"issue":"3","key":"pone.0343615.ref005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/ajhp\/zxab367","article-title":"Persistent postoperative opioid use after total hip or knee arthroplasty: a systematic review and meta-analysis","volume":"79","author":"HP Tay","year":"2022","journal-title":"Am J Health Syst Pharm"},{"issue":"1","key":"pone.0343615.ref006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pain.0000000000000003","article-title":"Postoperative pain treatment after total hip arthroplasty: a systematic review","volume":"156","author":"AP H\u00f8jer Karlsen","year":"2015","journal-title":"Pain"},{"issue":"3","key":"pone.0343615.ref007","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/rapm-2021-103228","article-title":"Preoperative 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pericapsular nerve group (PENG) block for primary total hip arthroplasty under spinal anaesthesia: a randomised controlled observer-blinded trial","volume":"130","author":"P Kukreja","year":"2023","journal-title":"Br J Anaesth"},{"issue":"3","key":"pone.0343615.ref011","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3390\/jpm12030408","article-title":"Pericapsular nerve group (PENG) block versus supra-inguinal fascia iliaca compartment block for total hip arthroplasty: a randomized clinical trial","volume":"12","author":"YS Choi","year":"2022","journal-title":"J Pers Med"},{"issue":"7","key":"pone.0343615.ref012","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/rapm-2024-105459","article-title":"Pericapsular nerve group block: a 3D CT scan imaging study to determine the spread of injectate","volume":"50","author":"AL Balocco","year":"2025","journal-title":"Reg Anesth Pain 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Anesth"},{"issue":"3","key":"pone.0343615.ref019","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1053\/j.jvca.2019.10.027","article-title":"Reply to Aydin et al.: a novel indication of pericapsular nerve group block: surgical anesthesia for vein ligation and stripping","volume":"34","author":"L Gir\u00f3n-Arango","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"pone.0343615.ref020","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.2147\/JPR.S468863","article-title":"Impact of different volumes of pericapsular nerve group block on pain during spinal anesthesia positioning and postoperative opioid requirements in femoral fracture surgeries; randomized prospective study","volume":"17","author":"G Erta\u015f","year":"2024","journal-title":"J Pain Res"},{"issue":"11","key":"pone.0343615.ref021","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/rapm-2023-104419","article-title":"Cadaveric study investigating the femoral nerve-sparing 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