{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:24:18Z","timestamp":1774290258216,"version":"3.50.1"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["project AR041215-02"],"award-info":[{"award-number":["project AR041215-02"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["project Z01 ES101081"],"award-info":[{"award-number":["project Z01 ES101081"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hope Pharmaceuticals"},{"name":"Hope Pharmaceuticals"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background\/Objective<\/jats:title>\n                    <jats:p>Dermatomyositis (DM) and juvenile dermatomyositis (JDM) are inflammatory myopathies affecting multiple organs, including muscle and skin. Calcinosis is a complication of DM\/JDM that causes significant morbidity; however, few tools exist to assess calcinosis in DM\/JDM patients This study aimed to evaluate the reliability of durometry measurements to assess the firmness of calcinosis lesions in DM and JDM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Calcinosis firmness was measured using a handheld digital durometer. Six investigators across 3 institutions examined DM\/JDM calcinosis lesions by durometry, as well as control readings in healthy unaffected skin\/subcutaneous tissue in similar anatomic areas, recording three readings per site. Intra-rater and inter-rater intraclass correlations were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 57 patients and gathered 709 measurements (443 calcinosis lesions; 266 control lesions) over eleven anatomic regions. Intra-rater reliability was high across sites, while inter-rater reliability varied, being moderate to good in most areas, but poor in the thigh and anterior calf. Durometry readings were higher in calcinosis lesions than control sites overall. Measurements moderately correlated with qualitative physician assessments. Due to our study\u2019s cross-sectional nature, we could not assess calcinosis over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Durometry is a novel, reliable, quantitative measure in assessing and characterizing targeted calcinosis lesions of DM\/JDM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0343708","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:29:54Z","timestamp":1774286994000},"page":"e0343708","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reliability of durometry to assess firmness of calcinosis lesions in Juvenile and adult dermatomyositis"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-4045","authenticated-orcid":true,"given":"Meghan 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sclerosis","volume":"55","author":"EY Kissin","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"10","key":"pone.0343708.ref008","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1001\/archderm.1995.01690220066013","article-title":"Reproducible measurements to quantify cutaneous involvement in scleroderma","volume":"131","author":"D Aghassi","year":"1995","journal-title":"Arch Dermatol"},{"issue":"6","key":"pone.0343708.ref009","first-page":"1092","article-title":"Treatment of calcinosis associated with adult and juvenile dermatomyositis using topical sodium thiosulfate via fractionated CO2 laser treatment","volume":"37","author":"MG Eleryan","year":"2019","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"pone.0343708.ref010","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11926-996-0031-5","article-title":"Clinical manifestations and pathogenesis of hydroxyapatite crystal deposition in juvenile dermatomyositis","volume":"8","author":"LM Pachman","year":"2006","journal-title":"Curr Rheumatol Rep"},{"issue":"8","key":"pone.0343708.ref011","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM197502202920807","article-title":"Polymyositis and dermatomyositis (second of two parts)","volume":"292","author":"A Bohan","year":"1975","journal-title":"N Engl J Med"},{"issue":"12","key":"pone.0343708.ref012","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1136\/annrheumdis-2017-211468","article-title":"2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups","volume":"76","author":"IE Lundberg","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"pone.0343708.ref013","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1172\/JCI116493","article-title":"Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases 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