{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:06:12Z","timestamp":1779473172716,"version":"3.53.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to assess the association between multiple atherogenic and insulin resistance indices\u2014including TyG, TyG-BMI, AIP, TG-HDL, and METS-IR\u2014and infertility in women with PCOS, and to evaluate their clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, we analyzed data from 669 sexually active women aged 18\u201345 with PCOS treated at a tertiary center in Iran (2021\u20132023). We compared infertile women with PCOS (\u226512 months unsuccessful conception, n\u2009=\u2009274) to fertile women with PCOS (n\u2009=\u2009395). Logistic regression, restricted cubic spline, and receiver operating characteristic (ROC) analysis were used to assess associations and predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Infertile women had significantly worse metabolic profiles across all indices (P\u2009&lt;\u20090.001). AIP showed the largest point estimate of association (adjusted OR = 9.065, 95% CI: 1.722\u201347.721). TG-HDL showed a significant non-linear relationship, with ORs rising steeply up to a ratio of ~2.5. Predictive ability was modest, with AUCs ranging from 0.598 (TyG-BMI) to 0.625 (AIP, TG-HDL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several metabolic indices, particularly AIP, are associated with infertility in women with PCOS, though their standalone predictive utility remains limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0343783","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T17:32:21Z","timestamp":1779471141000},"page":"e0343783","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome 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