{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:47:34Z","timestamp":1792086454528,"version":"4.4.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GBA","award":["01VSF18051"],"award-info":[{"award-number":["01VSF18051"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) are very similar regarding pathophysiology and clinical treatments, especially NSTEMI comprises a much more heterogenic group of patients and underlying diseases. We therefore aimed to assess the treatments and outcomes of both entities in a large contemporary cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with STEMI and NSTEMI between 01\/01\/2010\u201331\/12\/2018 were identified from the largest German health insurance (AOK,\u2009\u2248\u200926 million members). Patient demographics, their hospital course, adherence to guideline-directed drug therapy and overall survival were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total 544,529 patients (mean age 74, IQR 62\u201382), one third of whom had a STEMI. Chronic kidney disease, peripheral arterial disease, and heart failure were more common in patients with NSTEMI. Patients with STEMI were more likely to get coronary angiograms and percutaneous coronary interventions. Although STEMI more frequently led to cardiogenic shock, the rate of serious cardiac events was lower. Mortality was higher for STEMI only within the first 30 days, whereas long-term survival rates were better. The combination of statins, angiotensin converting enzyme inhibitors\/angiotensin receptor blockers, beta blockers, and oral anticoagulants or antiplatelet agents was associated with higher overall survival in patients with STEMI (hazard ratio [HR] 0.21; 95% confidence interval [95%CI] 0.20\u20130.23; p\u2009&lt;\u20090.001) or NSTEMI (HR 0.40; 95%CI 0.38\u20130.42; p\u2009&lt;\u20090.001). Nevertheless, the prescription rates decreased over time, particular in patients with NSTEMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clear differences between STEMI and NSTEMI were observed regarding short- and long-term survival. Guideline-recommended therapy improved long-term survival, but decreased during the follow-up period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0343889","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:10Z","timestamp":1792085170000},"page":"e0343889","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in treatment and outcome of patients with ST- elevation myocardial infarction (STEMI) and non-STEMI in Germany"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-6228","authenticated-orcid":true,"given":"Stefan A.","family":"Lange","sequence":"first","affiliation":[{"name":"University Hospital Muenster, Cardiology","place":["Muenster, Germany"],"department":["Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart 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Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-4142","authenticated-orcid":true,"given":"Thomas","family":"Ruhnke","sequence":"additional","affiliation":[{"name":"AOK Research Institute (WIdO)","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"G\u00fcnster","sequence":"additional","affiliation":[{"name":"AOK Research Institute (WIdO)","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-683X","authenticated-orcid":true,"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[{"name":"University of Muenster, Institute of Biostatistics and Clinical Research","place":["Muenster, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"University Hospital Muenster, 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