{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:24:07Z","timestamp":1773685447734,"version":"3.50.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit Programme","doi-asserted-by":"publisher","award":["NIHR207157"],"award-info":[{"award-number":["NIHR207157"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"The University of Manchester","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Patients with psoriasis are less physically active than age-matched controls, due to psoriasis-specific barriers; significantly limiting their ability to benefit from health-promoting levels of physical activity. We co-designed an exercise intervention, with patients, which in proof-of-concept studies, led to significantly improved psoriasis; reduced cardiovascular disease\/metabolic syndrome risk and enhanced wellbeing\/psychosocial functioning. This suggested increased physical activity may improve health outcomes for those with psoriasis. However, individuals remained sedentary for prolonged periods, which also has a detrimental effect on health. We therefore developed a new intervention \u2013 MOVE SMART \u2013 to increase light-intensity physical activity and interrupt sedentary behaviour. This randomised controlled clinical trial (RCT) will assess the feasibility and acceptability of MOVE SMART. Utilising a decentralised, two-arm, trial design, people with Type 1 psoriasis with\/without stable psoriatic arthritis, (n\u2009=\u200960) will be recruited from across the UK, and randomised to intervention (MOVE SMART with \u201cStandard Care\u201d, n\u2009=\u200930) or control (\u201cStandard Care\u201d, n\u2009=\u200930). The intervention group will follow MOVE SMART for 12-weeks, followed by activities of their own choice during weeks 13\u201324. MOVE SMART will prompt 2-minutes of light-intensity physical activity, following 30-minutes of continuous sedentary behaviour, during daytime waking hours. The study comprises of three Workstreams. In Workstream-1 participants will use wearable devices to allow monitoring of physical behaviour and adherence to MOVE SMART. A blood pressure monitor and body weight scales will be posted to participants for use throughout the study and functional capacity will be measured by video-link. At baseline, week-12 and \u221224 all participants will complete self-assessment of the extent\/impact of psoriasis and wellbeing. Capillary blood will be collected using home-sampling kits. In Workstream-2 acceptability of the intervention will be evaluated and the trial design will be finalised in Workstream-3. The study is registered at\n www.isrctn.com<\/jats:ext-link>\n (ISRCTN 17400289).\n <\/jats:p>","DOI":"10.1371\/journal.pone.0343922","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:28:00Z","timestamp":1773682080000},"page":"e0343922","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study protocol for a feasibility randomised controlled trial of MOVE SMART\u2014An intervention to increase physical activity, reduce sedentary behaviour and improve health outcomes in patients with psoriasis"],"prefix":"10.1371","volume":"21","author":[{"given":"Gladys","family":"Onambele-Pearson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-0693","authenticated-orcid":true,"given":"Ben","family":"Ives","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishani","family":"Khosla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozemarijn","family":"Witkam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Moorhead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Bedson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russ","family":"Cowper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girvan","family":"Burnside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-445X","authenticated-orcid":true,"given":"Helen S.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"pone.0343922.ref001","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1139\/h2012-024","article-title":"Standardized use of the terms \u201csedentary\u201d and \u201csedentary behaviours\u201d","volume":"37","author":"Sedentary Behaviour Research Network","year":"2012","journal-title":"Appl Physiol Nutr Metab"},{"issue":"10051","key":"pone.0343922.ref002","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(16)30370-1","article-title":"Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? 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