{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:13:00Z","timestamp":1773879180485,"version":"3.50.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine reference intervals (RI) for thyroid hormones based on thyroid antibody levels using different autoanalyzer kits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      RI for Thyroid-stimulating hormone (TSH), free thyroxine (fT\n                      <jats:sub>4<\/jats:sub>\n                      ) and free triiodothyronine (fT\n                      <jats:sub>3<\/jats:sub>\n                      ) were determined according to thyroid antibody levels and independently of thyroid antibody levels using the R statistical program and RefineR algorithm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant differences in RIs were found between antibody-positive (Ab(+)) and antibody-negative (Ab(\u2013)) individuals. TSH RI varied most notably in Abbott and Siemens analyzers. In females, Abbott showed higher TSH RIs in the Ab(+) group (0.41\u20137.44 mU\/L) than in Ab(\u2013) (0.24\u20133.50 mU\/L). In males, Roche and Beckman exhibited the greatest differences (Roche Ab(+): 0.19\u20135.77; Ab(\u2013): 0.44\u20133.63; Beckman Ab(+): 0.12\u20135.23; Ab(\u2013): 0.39\u20133.96 mU\/L). For fT4, Roche showed increased RIs in females with Ab(+) status (11.42\u201320.42 vs. 10.34\u201319.35 pmol\/L). In males, Beckman and Siemens autoanalyzers also indicated notable differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antibody status significantly affects thyroid hormone RI, particularly for TSH. These findings highlight the need for antibody-specific RI and further standardization in establishing reference intervals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0344197","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:41:06Z","timestamp":1773855666000},"page":"e0344197","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of thyroid hormones reference intervals based on thyroid antibody levels: A multicenter 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