{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:30:20Z","timestamp":1773235820940,"version":"3.50.1"},"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["42325"],"award-info":[{"award-number":["42325"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Despite advances in reducing cardiovascular disease (CVD) incidence, CVD mortality has increased, emphasising the need for new preventive strategies. Polyphenol-rich olive extracts have been proposed to lower blood pressure by reducing oxidative stress and enhancing nitric oxide production. This double-blind, placebo-controlled, randomised study aims to examine whether a standardised olive extract can lead to a reduction in blood pressure, lipid levels, and biological markers of oxidative stress after supplementation in the context of primary CVD prevention. In this trial, 56 participants with a systolic blood pressure\u2009\u2265\u2009130 mmHg received capsules containing 440\u2009mg olive dry extract (123.5\u2009\u00b1\u20099.4\u2009mg oleuropein, 25.0\u2009\u00b1\u20093.8\u2009mg hydroxytyrosol) or placebo on a daily basis over eight weeks. Both groups showed significant reductions in systolic blood pressure with a larger decrease in the intervention group as compared to the control group (intervention: \u22128.3\u2009\u00b1\u20092.2 mmHg, control: \u22127.3\u2009\u00b1\u20092.2 mmHg). However, this decrease was not found significantly different between the two groups. Moreover, total cholesterol, LDL, and apo B levels decreased in both groups, but with no significant difference between them. These results indicate that the olive extract was well-tolerated, although no significant hypotensive benefit was observed, with effects paralleling typical placebo responses in hypertension trials. Literature reports conflicting results on the hypotensive effect of olive polyphenols, indicating the need for further research with well-designed clinical trials. This trial was registered on Clinicaltrials.gov in April 2021, ID NCT04874961.<\/jats:p>","DOI":"10.1371\/journal.pone.0344278","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:28:02Z","timestamp":1773163682000},"page":"e0344278","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the effect of olive extracts on blood pressure and cardiovascular health markers in adults: Findings from a double-blind, placebo-controlled, randomised trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-5176","authenticated-orcid":true,"given":"Stef","family":"Lauwers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Breynaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Verlaet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tijs","family":"Bringmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3765-0341","authenticated-orcid":true,"given":"Emmy","family":"Tuenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Bosmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-7313","authenticated-orcid":true,"given":"Nina","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"issue":"9","key":"pone.0344278.ref001","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000652","article-title":"Call to action: urgent challenges in cardiovascular disease: a presidential advisory from the American Heart Association","volume":"139","author":"M McClellan","year":"2019","journal-title":"Circulation"},{"issue":"5","key":"pone.0344278.ref002","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1001\/jamacardio.2016.1326","article-title":"Recent Trends in cardiovascular mortality in the United States and Public Health Goals","volume":"1","author":"S Sidney","year":"2016","journal-title":"JAMA Cardiol"},{"issue":"10","key":"pone.0344278.ref003","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2105\/AJPH.2017.303941","article-title":"The epidemic of despair among white americans: trends in the leading causes of premature death, 1999-2015","volume":"107","author":"EM Stein","year":"2017","journal-title":"Am J Public Health"},{"key":"pone.0344278.ref004","first-page":"345","article-title":"Impact of aging on cardiovascular diseases.","volume":"4","author":"D Zhao","year":"2024","journal-title":"JACC: Asia"},{"issue":"5","key":"pone.0344278.ref005","article-title":"Life\u2019s essential 8: updating and enhancing the American Heart Association\u2019s construct of cardiovascular health: a presidential advisory from the American Heart Association","volume":"146","author":"DM Lloyd-Jones","year":"2022","journal-title":"Circulation"},{"issue":"9349","key":"pone.0344278.ref006","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Prospective Studies Collaboration","year":"2002","journal-title":"Lancet"},{"issue":"18","key":"pone.0344278.ref007","doi-asserted-by":"crossref","first-page":"436","DOI":"10.21037\/atm.2019.09.04","article-title":"Prevalence of hypertension, diabetes, and dyslipidemia, and their additive effects on myocardial infarction and stroke: a cross-sectional study in Nanjing, China","volume":"7","author":"S Lu","year":"2019","journal-title":"Ann Transl Med"},{"issue":"6","key":"pone.0344278.ref008","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/hr.2011.6","article-title":"Are blood pressure and diabetes additive or synergistic risk factors? 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