{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:12:15Z","timestamp":1778523135788,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Despite significant advances in antiretroviral therapy (ART) accessibility in Ghana, suboptimal adherence remains a critical challenge undermining treatment effectiveness. This article presents evidence-based policy hypotheses derived from a comprehensive mixed-methods investigation of ART adherence determinants among 2,000 people living with HIV in Ghana#39;s Ashanti Region. We hypothesize that multisectoral policy interventions addressing economic barriers, healthcare system deficiencies, and socio-cultural obstacles will significantly improve adherence rates beyond conventional clinical approaches. Specifically, we propose that: (1) integrated transportation support systems will substantially reduce missed appointments; (2) decentralized medication distribution networks incorporating community-based refill options will improve medication access; (3) restructured clinic operations emphasizing reduced waiting times and privacy protection will enhance engagement; and (4) formalized income protection and nutritional support policies will address critical economic barriers to consistent treatment. These policy hypotheses extend beyond individual-focused interventions to address structural determinants of adherence, offering testable frameworks for evidence-based policy development in resource-limited settings.<\/jats:p>","DOI":"10.1371\/journal.pone.0344395","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:31:42Z","timestamp":1778520702000},"page":"e0344395","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Translating research into action: Policy recommendations for strengthening antiretroviral therapy adherence in Ghana based on empirical evidence"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1738-963X","authenticated-orcid":true,"given":"Victor Luckyboy","family":"Dzramado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obed 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