{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:03:58Z","timestamp":1784570638806,"version":"3.55.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["100019_134975, 100019_156610, 10FI14_170408, 10FI14_198055"],"award-info":[{"award-number":["100019_134975, 100019_156610, 10FI14_170408, 10FI14_198055"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003986","name":"Jacobs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009065","name":"Paul Schiller Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The present study examines the link between DNA methylation at the nerve growth factor-induced protein A (NGFI-A) binding domain of the\n                      <jats:italic>NR3C1<\/jats:italic>\n                      1F promoter and later cognitive functions in children from families living in disadvantaged psychosocial conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were 132 children who took part in a Swiss Parents as Teachers (PAT) randomized controlled trial (72 in the intervention group, 60 in the control group). DNA methylation was quantified from saliva samples collected at age three using sodium bisulfite next-generation sequencing (NGS). Cognitive functions were assessed at age five using the SON-R 2.5\u20137 Intelligence Test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(a) DNA methylation at age three was associated with lower IQ at age five through increased concentration problems (indirect effect\u2009=\u2009\u22120.083, p\u2009=\u2009.012); (b) parental disagreement was associated with concentration difficulties through DNA methylation (indirect effect\u2009=\u20090.064, p\u2009=\u2009.023); and (c) participation in the three-year PAT program was associated with lower methylation levels (\u03b2\u2009=\u2009\u22120.375, p\u2009=\u2009.041). The serial pathway from parental disagreement to IQ via methylation and concentration was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings provide preliminary evidence for an association between early DNA methylation at the NGFI-A binding site of the NR3C1 1F promoter and later cognitive functions in children and highlight the potential role of early life stressors and the PAT intervention in shaping these associations. However, given the exploratory nature of this study, replication in larger independent samples is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0344401","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:30:51Z","timestamp":1784568651000},"page":"e0344401","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early DNA methylation at the NGFI-A binding site of the NR3C1 1F promoter predicts cognitive functions at age five: Evidence from the Parents as Teachers intervention in the ZEPPELIN study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-096X","authenticated-orcid":true,"given":"Elena 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Available from: https:\/\/parentsasteachers.org\/what-we-do\/our-model\/evidence-based-model\/"},{"issue":"1","key":"pone.0344401.ref042","doi-asserted-by":"crossref","DOI":"10.2307\/1602723","article-title":"The parents as teachers program: results from two demonstrations","volume":"9","author":"MM Wagner","year":"1999","journal-title":"Future Child"},{"issue":"6","key":"pone.0344401.ref043","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2105\/AJPH.2012.300996","article-title":"Behavioral and socioemotional outcomes through age 5 years of the legacy for children public health approach to improving developmental outcomes among children born into poverty","volume":"103","author":"JW Kaminski","year":"2013","journal-title":"Am J Public Health"},{"key":"pone.0344401.ref044","volume-title":"Snijders-oomen non-verbaler intelligenztest 2 1\/2\u20137: revidierte fassung","author":"PJ Tellegen","year":"2007"},{"key":"pone.0344401.ref045","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1017\/S0954579417001407","article-title":"Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), in maltreated and nonmaltreated children: associations with behavioral undercontrol, emotional lability\/negativity, and externalizing and internalizing symptoms","volume":"29","author":"D Cicchetti","year":"2017","journal-title":"Dev Psychopathol"},{"issue":"1","key":"pone.0344401.ref046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15295192.2012.638870","article-title":"A multi-domain self-report measure of coparenting","volume":"12","author":"ME Feinberg","year":"2012","journal-title":"Parent Sci Pract"},{"issue":"11","key":"pone.0344401.ref047","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S0006-3223(99)00224-3","article-title":"The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders","volume":"46","author":"C Heim","year":"1999","journal-title":"Biol Psychiatry"},{"key":"pone.0344401.ref048","volume-title":"Elternstressfragebogen (ESF). Manual","author":"H Domsch","year":"2010"},{"issue":"1","key":"pone.0344401.ref049","article-title":"Epigenetics applied to child and adolescent mental health: progress, challenges and opportunities","volume":"3","author":"CAM Cecil","year":"2022","journal-title":"JCPP Adv"},{"issue":"15","key":"pone.0344401.ref050","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"AM Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"pone.0344401.ref051","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/03637750903310360","article-title":"Beyond Baron and Kenny: statistical mediation analysis in the new millennium","volume":"76","author":"AF Hayes","year":"2009","journal-title":"Commun Monogr"},{"key":"pone.0344401.ref052","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1086\/651257","article-title":"Reconsidering Baron and 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