{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:06:18Z","timestamp":1790186778859,"version":"4.1.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mental well-being encompasses positive psychological functioning, life satisfaction, and engagement with daily activities. It is influenced by multiple interrelated factors, including symptoms of stress, anxiety, depression, and psychological inflexibility. Network analysis provides a data-driven framework for examining the complex interconnections between these components and for identifying elements that may play a central role in the mental well-being system. The present study aimed to identify key elements related to stress, anxiety, depression, and psychological inflexibility associated with mental well-being in individuals seeking online psychological support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study analyzed data drawn from the Well-being online intervention. A total of 941 Mexican participants were included. A psychological network comprising seventy-four items was estimated, and centrality indices (strength, closeness, and betweenness) were computed to determine the relative importance of individual elements within the network. Network comparisons by gender were conducted to evaluate global and local differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The network revealed multiple inter-domain associations, particularly negative relationships between mental well-being and symptoms of depression, anxiety, negative stress, and psychological inflexibility. Items reflecting self-evaluation and emotional well-being consistently emerged as the most central elements in the network across centrality metrics. Gender-based comparisons indicated overall structural similarity between networks, although differences were observed in the strength of specific connections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Network analysis identified central elements linking mental well-being with psychological distress and inflexibility in a population seeking online psychological support. These findings contribute to a systems-level understanding of mental well-being and highlight potential targets for psychological interventions to enhance well-being and reduce distress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0344411","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:26:42Z","timestamp":1790184402000},"page":"e0344411","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network analysis of mental well-being, psychological inflexibility, and psychopathological symptoms in individuals seeking online psychological support"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2952-2836","authenticated-orcid":true,"given":"Leivy Patricia","family":"Gonz\u00e1lez-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences","place":["Guadalajara, Jalisco, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Omar","family":"Gonz\u00e1lez-Cantero","sequence":"additional","affiliation":[{"name":"Centro Universitario de los Valles, Universidad de Guadalajara","place":["Ameca, Jalisco, M\u00e9xico"],"department":["Departamento de Ciencias del Comportamiento"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyna Jazm\u00edn","family":"Mart\u00ednez-Arriaga","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences","place":["Guadalajara, Jalisco, M\u00e9xico"]},{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara","place":["Jalisco, M\u00e9xico"],"department":["Departamento de Cl\u00ednicas de Salud Mental"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-4151","authenticated-orcid":true,"given":"Said","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Medicine and Health Sciences","place":["Ciudad de M\u00e9xico, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina Erika","family":"Herdoiza-Arroyo","sequence":"additional","affiliation":[{"name":"Health and Life Sciences, Universidad Internacional del Ecuador UIDE","place":["Quito, Ecuador"],"department":["Faculty of Medical"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Robles-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud Mental Global, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz","place":["Ciudad de M\u00e9xico, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Olimpia","family":"Castellanos-Vargas","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas. Universidad Aut\u00f3noma de Ciudad Ju\u00e1rez","place":["Ciudad Ju\u00e1rez, Chihuahua, M\u00e9xico"],"department":["Departamento de Ciencias de la Salud"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-8824","authenticated-orcid":true,"given":"Alejandro","family":"Dominguez-Rodriguez","sequence":"additional","affiliation":[{"name":"Health and Technology, University of Twente","place":["Enschede, the Netherlands"],"department":["Department of Psychology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"pone.0344411.ref001","doi-asserted-by":"crossref","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_707_23","article-title":"Concept of mental health and mental well-being, it\u2019s determinants and coping strategies","volume":"66","author":"S Gautam","year":"2024","journal-title":"Indian J Psychiatry"},{"key":"pone.0344411.ref002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.psych.52.1.141","article-title":"On happiness and human potentials: a review of research on hedonic and eudaimonic well-being","volume":"52","author":"RM Ryan","year":"2001","journal-title":"Annu Rev Psychol"},{"issue":"9","key":"pone.0344411.ref003","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1007\/s12144-020-01074-8","article-title":"Psychological inflexibility mediates the relationship between fear of negative evaluation and psychological vulnerability","volume":"40","author":"E U\u011fur","year":"2021","journal-title":"Curr Psychol"},{"key":"pone.0344411.ref004","doi-asserted-by":"crossref","first-page":"886344","DOI":"10.3389\/fpsyg.2022.886344","article-title":"Academic Stress and Mental Well-Being in College Students: Correlations, Affected Groups, and COVID-19","volume":"13","author":"G Barbayannis","year":"2022","journal-title":"Front Psychol"},{"issue":"6","key":"pone.0344411.ref005","first-page":"527","article-title":"Los trastornos mentales en M\u00e9xico 1990-2021. 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