{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:06Z","timestamp":1787022186599,"version":"build-2736575974"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the clinical application of fetal nuchal translucency (NT) combined with noninvasive prenatal testing (NIPT) in screening for fetal chromosomal diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on NIPT results, prenatal diagnoses, and pregnancy outcomes of early pregnant women with enlarged NT at our center from 01\/07\/2018 to 01\/01\/2021. To ensure data integrity and minimize extraction bias, phased data access was adopted: the first batch of data was extracted from 01\/07\/2019 (start of Phase 1) to 20\/07\/2019 (end of Phase 1), covering participants examined from 01\/07\/2018 to 30\/06\/2019; the second batch was extracted from 01\/02\/2020 (start of Phase 2) to 20\/02\/2020 (end of Phase 2), including participants examined from 01\/07\/2019 to 01\/01\/2020. Chi-square tests were used to compare the incidence of fetal chromosomal abnormalities between the enlarged NT and normal NT groups, as well as among the subgroups of enlarged NT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 48,130 women screened by NIPT, 774 had enlarged NT (\u22652.5 mm); among these, 85 were classified as high-risk, and 72 underwent invasive diagnosis, resulting in 64 positive cases (including 42 cases of trisomy 21, among others). The thickening of NT was correlated with a higher detection rate of abnormalities, which was statistically significant. Among the 689 cases of enlarged NT with low-risk NIPT results, 20 were lost to follow-up, 5 terminated their pregnancies, while the others had healthy live births.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early pregnancy NT combined with NIPT demonstrates a high predictive value for fetal chromosomal abnormalities and holds significant importance for clinical pregnancy guidance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0344739","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:22:02Z","timestamp":1773681722000},"page":"e0344739","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical application of fetal Nuchal Translucency combined with noninvasive prenatal testing in screening chromosome abnormalities"],"prefix":"10.1371","volume":"21","author":[{"given":"Guangzhen","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-9238","authenticated-orcid":true,"given":"Shuang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"pone.0344739.ref001","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24997","article-title":"Evaluation of chromosomal abnormalities in the postnatal cohort: A single-center study on 14,242 patients","volume":"38","author":"H Akalin","year":"2024","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"pone.0344739.ref002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.nec.2021.09.012","article-title":"Neurosurgical Evaluation and Management of Patients with Chromosomal Abnormalities","volume":"33","author":"JA Stadler","year":"2022","journal-title":"Neurosurg Clin N Am"},{"issue":"6","key":"pone.0344739.ref003","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/aogs.13877","article-title":"Nuchal translucency of 3.0-3.4 mm an indication for NIPT or microarray? 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