{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:24:36Z","timestamp":1774290276553,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Developing a non-invasive model is essential for assessing liver stiffness in conditions without transient elastography, which will determine further management in chronic hepatitis B (CHB) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate the interleukin-13 role in liver fibrosis and develop a new predictive model that includes interleukin-13 and standard data such as age and platelet count.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were recruited from Hasan Sadikin General Hospital\u2019s CHB registry from October 2021 to January 2022. Patients underwent demographic data collection, complete blood count, interleukin-13, and transient elastography examinations on the same day. The platelet count variable was listed in \u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/ dL, and the interleukin-13 in pg\/mL. Interleukin-13 values were categorized as positive for IL-13 with a cut-off of 5 pg\/mL (ILcut5). The liver stiffness measurement was inverted to obtain a normal distribution and became inverseLSM as the model\u2019s outcome. The prediction model was formed through multiple linear regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results and Discussion<\/jats:title>\n                    <jats:p>\n                      The number of patients studied was 88. A prediction model for inverseLSM was formulated, had an R\n                      <jats:sup>2<\/jats:sup>\n                      of 0.37, and consisted of age, platelet count, and ILcut5 with correlation coefficients of -0.221, 0.326, and \u22120.288, respectively. The model had no autocorrelation, multicollinearity, or significant outliers, a normal distribution appearance, and met the homoscedastic criterion. Elevated IL-13, decreased platelet count, and aging are linked to increased liver stiffness.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0344791","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:30:26Z","timestamp":1774287026000},"page":"e0344791","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the role of interleukin-13 in liver fibrosis of chronic hepatitis B patients: Development of a predictive model"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-8213","authenticated-orcid":true,"given":"Muhammad Begawan","family":"Bestari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-9014","authenticated-orcid":true,"given":"Muhammad Palar","family":"Wijaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolvy","family":"Girawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenny","family":"Agustanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-6354","authenticated-orcid":true,"given":"Eka Surya","family":"Nugraha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"pone.0344791.ref001","unstructured":"World Health Organization (WHO). 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