{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:31:55Z","timestamp":1776400315319,"version":"3.51.2"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS090030"],"award-info":[{"award-number":["NS090030"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS055272"],"award-info":[{"award-number":["NS055272"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["EY031690"],"award-info":[{"award-number":["EY031690"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    There are\u2009~\u200960 clustered protocadherin (cPcdh) isoforms expressed from three gene clusters (\n                    <jats:italic>Pcdha<\/jats:italic>\n                    ,\n                    <jats:italic>Pcdhb<\/jats:italic>\n                    ,\n                    <jats:italic>Pcdhg<\/jats:italic>\n                    ) arrayed in tandem across nearly 1 Mb in mammals. cPcdhs are homophilic cell adhesion molecules (CAMs) critical for a host of neural developmental functions consistent with a role in cell-cell recognition. Indeed, isoforms make recognition modules in combination to generate recognition diversity far exceeding the\u2009~\u200960 individual CAMs. However, there is also growing evidence for specialized functions for specific isoforms, particularly the C-type isoforms found at the 3\u2019 ends of the\n                    <jats:italic>Pcdha<\/jats:italic>\n                    cluster (\u03b1C1 and \u03b1C2) and at the 3\u2019 end of the\n                    <jats:italic>Pcdhg<\/jats:italic>\n                    cluster (\u03b3C3, \u03b3C4, and \u03b3C5). We have previously described unique roles for \u03b3C3 in dendrite arborization in the cerebral cortex and neural circuit formation in the spinal cord, as well as for \u03b3C4 in neuronal survival. Here we report a new mouse mutant specifically targeting the\n                    <jats:italic>Pcdhgc5<\/jats:italic>\n                    exon encoding \u03b3C5. Unlike the rest of the\n                    <jats:italic>Pcdhg<\/jats:italic>\n                    cluster, expression of this isoform does not begin until postnatal stages of mouse development, increasing in the second week of life, suggesting specialized roles. We found significant expression changes in gene pathways involved in synaptic activity, learning and memory, and cognition. Despite this, we saw no major disruption in the cerebral cortex in neuronal organization, survival, dendritic arborization, or synaptic protein expression in these mutants. This new model will be an important tool for future studies delineating specific functions for \u03b3C5.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0344863","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:30:20Z","timestamp":1773336620000},"page":"e0344863","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin \u03b3C5 isoform is not essential for dendrite arborization in the cerebral cortex"],"prefix":"10.1371","volume":"21","author":[{"given":"Camille M.","family":"Hanes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George C.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-2847","authenticated-orcid":true,"given":"Joshua A.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-2585","authenticated-orcid":true,"given":"Andrew M.","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"issue":"6","key":"pone.0344863.ref001","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)80789-8","article-title":"A striking organization of a large family of human neural cadherin-like cell adhesion 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