{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:00:32Z","timestamp":1774465232709,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&D Program of the China Ministry of Science and Technology","award":["2024YFC2510600"],"award-info":[{"award-number":["2024YFC2510600"]}]},{"name":"Major science and technology support plan of Hebei Province","award":["242W7710Z"],"award-info":[{"award-number":["242W7710Z"]}]},{"name":"The Natural Science Foundation of Hebei Province","award":["H2024206134"],"award-info":[{"award-number":["H2024206134"]}]},{"name":"The Natural Science Foundation of Hebei Province","award":["H2024206027"],"award-info":[{"award-number":["H2024206027"]}]},{"name":"Hebei Province Higher Education Science and Technology Research Project"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current noninvasive diagnostics for acute compartment syndrome (ACS) lack clinical practicality and reliability. This study aimed to evaluate ultrasound-derived tibia-fascia angle (TFA) as a novel morphometric surrogate for intracompartmental pressure (ICP) assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational study, 105 patients with closed tibial plateau fractures were enrolled at a tertiary trauma center. TFA was bilaterally measured using B-mode ultrasound by blinded operators. Invasive ICP served as the reference standard. Correlations were analyzed via Spearman correlation analysis and multivariable linear regression, and diagnostic performance for high compartment pressure (HCP, ICP\u2009&gt;\u200930 mmHg) was assessed using ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u0394TFA showed a significant linear correlation with ICP after adjustment for confounders (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20091.74 mmHg\/\u00b0, 95% CI: 1.07\u20132.41,\n                      <jats:italic>P<\/jats:italic>\n                      adj\u2009&lt;\u20090.001) and a moderate monotonic association (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.545, 95%CI: 0.395\u20130.667,\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.001). For detecting HCP, \u0394TFA achieved an area under the receiver operating characteristic curve (AUC) of 0.716 (95% CI: 0.621\u20130.812), with 86.5% sensitivity and 52.9% specificity at the optimal cutoff (\u0394TFA\u2009\u2265\u20094.9\u00b0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u0394TFA provides a rapid, operator-friendly method for noninvasive ICP estimation, demonstrating moderate diagnostic accuracy as a screening tool for HCP in tibial plateau fractures. Its integration into trauma workflows could enhance early risk stratification, particularly for high-energy fractures, though specificity limitations warrant complementary confirmatory tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0344990","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:44:42Z","timestamp":1774460682000},"page":"e0344990","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-derived tibia-fascia angle for noninvasive assessment of intracompartmental pressure in tibial plateau 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segmental single compartment syndrome following an Achilles tendon repair: A case report and literature review","volume":"19","author":"L-F Jiang","year":"2016","journal-title":"Chin J Traumatol"},{"issue":"8","key":"pone.0344990.ref022","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.jbiomech.2004.07.030","article-title":"Evaluation of limb compartments with increased interstitial pressure. An improved noninvasive method for determining quantitative hardness","volume":"38","author":"BD Steinberg","year":"2005","journal-title":"J Biomech"},{"key":"pone.0344990.ref023","doi-asserted-by":"crossref","first-page":"1433284","DOI":"10.3389\/fbioe.2024.1433284","article-title":"Bioimpedance measurement: a non-invasive diagnosis of limb compartment syndrome","volume":"12","author":"M Novak","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"pone.0344990.ref024","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jbiomech.2018.11.045","article-title":"The shear modulus of lower-leg muscles correlates to intramuscular pressure","volume":"83","author":"S Sadeghi","year":"2019","journal-title":"J Biomech"},{"key":"pone.0344990.ref025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13017-019-0222-9","article-title":"Feasibility of ultrasound measurement in a human model of acute compartment syndrome","volume":"14","author":"J M\u00fchlbacher","year":"2019","journal-title":"World J Emerg Surg"},{"issue":"8","key":"pone.0344990.ref026","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.3390\/jcm13082327","article-title":"Patient-Reported Outcomes following Tibial Plateau Fractures: Mid- to Short-Term Implications for Knee Function and Activity Level","volume":"13","author":"C Neidlein","year":"2024","journal-title":"J Clin Med"},{"issue":"2","key":"pone.0344990.ref027","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.injury.2021.10.027","article-title":"A nomogram predicting risk for acute compartment syndrome following tibial plateau fractures. 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Large","year":"2015","journal-title":"J Orthop Trauma"},{"issue":"2","key":"pone.0344990.ref031","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00264-024-06402-2","article-title":"Development and validation of the nomogram of high fascial compartment pressure with pilon fracture","volume":"49","author":"X Hu","year":"2025","journal-title":"Int Orthop"},{"issue":"3","key":"pone.0344990.ref032","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1007\/s00330-024-11335-w","article-title":"Breast density assessment via quantitative sound-speed measurement using conventional ultrasound transducers","volume":"35","author":"CD Bezek","year":"2025","journal-title":"Eur Radiol"},{"issue":"6","key":"pone.0344990.ref033","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00404-025-08024-4","article-title":"Impact of sexual activity on bulbocavernosus muscle stiffness assessed by shear wave elastography in women","volume":"311","author":"R Du","year":"2025","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"pone.0344990.ref034","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00276-024-03361-6","article-title":"Regional variations and sex-related differences of stiffness in human tracheal ligaments","volume":"46","author":"K Fukushige","year":"2024","journal-title":"Surg Radiol Anat"},{"key":"pone.0344990.ref035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.aanat.2015.06.007","article-title":"Quantitative assessment of Thiel soft-embalmed human cadavers using shear wave elastography","volume":"202","author":"J Joy","year":"2015","journal-title":"Ann Anat"},{"issue":"1","key":"pone.0344990.ref036","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/ggi.13567","article-title":"Age-related changes in muscle elasticity and thickness of the lower extremities are associated with physical functions among community-dwelling older women","volume":"19","author":"A 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