{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:56:59Z","timestamp":1774465019598,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop predictive models using three-dimensional (3D) and conventional two-dimensional (2D) anterior-segment optical coherence tomography (AS-OCT) parameters for intraocular pressure (IOP) reduction following phacoemulsification in glaucoma and non-glaucoma cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included patients with and without glaucoma who underwent phacoemulsification. Preoperative predictors of 1-month IOP reduction, including clinical, ocular biometry, and AS-OCT (CASIA2) parameters, were analyzed. 3D AS-OCT measurements were assessed in two approaches: (1) averaging 360-degree values and (2) estimating circumferential areas or volumes. 2D variables were obtained from horizontal cross-sectional images. Model selection with least absolute shrinkage and selection operator (LASSO) for 2D and 3D variables was performed separately. R-squared (R\u00b2) used to represent model accuracy. The performance was validated by bootstrap resampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 130 eyes (64 glaucoma, 66 non-glaucoma) from 103 patients were included. The average IOP change was \u22121.20\u2009\u00b1\u20093.29 mmHg. Preoperative IOP (preIOP) was the strongest single predictor across all models. In the entire cohort, the final models showed moderate predictability (R\u00b2 38% for 3D and 36% for 2D; optimism-corrected R\u00b2 31% for both). In glaucoma eyes, models incorporating AS-OCT angle status and anterior chamber width achieved R\u00b2 values of 36% (3D) and 38% (2D), with optimism-corrected R\u00b2 of 27% (3D) and 28% (2D). In non-glaucoma eyes, both 3D and 2D models showed higher predictability (R\u00b2 53%, optimism-corrected R\u00b2 45%), with final predictors incorporating AS-OCT anterior chamber area and iris thickness. Both 3D and 2D models significantly outperformed the reference preIOP models across all cohorts (all p\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AS-OCT parameters improved the predictability of IOP reduction after phacoemulsification, with notably better performance in non-glaucoma eyes. 2D and 3D models showed comparable predictive ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0345582","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:37:57Z","timestamp":1774460277000},"page":"e0345582","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparable performance of 3D and 2D anterior segment optical coherence tomography in predicting intraocular pressure reduction following 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tomography","volume":"169","author":"EK Melese","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"pone.0345582.ref021","volume-title":"Asia Pacific Glaucoma Guidelines","author":"Group South East Asia Glaucoma Interest","year":"2024","edition":"4"},{"issue":"2","key":"pone.0345582.ref022","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"PJ Foster","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"pone.0345582.ref023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2018.01.006","article-title":"Anterior segment imaging for angle closure","volume":"188","author":"S Chansangpetch","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"pone.0345582.ref024","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/09286586.2012.674614","article-title":"Regression methods when the eye is the unit of 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Liu","year":"2011","journal-title":"J Glaucoma"},{"key":"pone.0345582.ref028","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"RD Riley","year":"2020","journal-title":"BMJ"},{"issue":"7","key":"pone.0345582.ref029","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1167\/iovs.10-6412","article-title":"Appositional closure identified by ultrasound biomicroscopy in population-based primary angle-closure glaucoma suspects: the Liwan eye study","volume":"52","author":"X Kong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"pone.0345582.ref030","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ophtha.2004.10.026","article-title":"Prevalence of appositional angle closure determined by ultrasonic biomicroscopy in eyes with shallow anterior chambers","volume":"112","author":"S 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