{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:29:23Z","timestamp":1774031363943,"version":"3.50.1"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objective<\/jats:title>\n To evaluate the diagnostic performance of maternal hemostatic and inflammatory markers in predicting neonatal sepsis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective case\u2013control study included 176 newborns, of whom 37 were diagnosed with neonatal sepsis and 139 were healthy controls. Maternal blood samples collected at delivery were analyzed for white blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (aPTT), international normalized ratio (INR), and systemic inflammatory indices (SII, SIRI, PIV). Group comparisons were performed using the Mann-Whitney U and Chi-square tests. Predictive markers were assessed using multivariate logistic regression and ROC curve analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Maternal PT was significantly higher in the sepsis group (p\u2009<\u20090.001), and multivariate logistic regression identified PT as the only independent predictor of neonatal sepsis (OR: 1.79; 95% CI: 1.39\u20132.31; p\u2009<\u20090.001). ROC analysis showed PT had the highest diagnostic accuracy (AUC: 0.909). The optimal cut-off value for PT was 10.25 seconds, yielding a sensitivity of 89.2% and specificity of 68.3%.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Maternal PT demonstrates excellent diagnostic accuracy in predicting neonatal sepsis. As one of the first studies to apply logistic regression and ROC analysis solely to maternal hemostatic and inflammatory markers, our findings suggest that maternal PT could serve as a valuable, easily obtainable biomarker for early neonatal sepsis risk stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0345672","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:41:25Z","timestamp":1774028485000},"page":"e0345672","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal prothrombin time as an independent predictor of neonatal sepsis: A retrospective case\u2013control study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-369X","authenticated-orcid":true,"given":"G\u00f6k\u00e7enur","family":"Karakelleo\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Ceren Nur","family":"K\u0131r\u0131ml\u0131 Yan\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eenol","family":"Bozda\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"issue":"10104","key":"pone.0345672.ref001","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","article-title":"Neonatal sepsis","volume":"390","author":"AL Shane","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"pone.0345672.ref002","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1542\/peds.2012-0541","article-title":"Management of neonates with suspected or proven early-onset bacterial sepsis","volume":"129","author":"Polin RA; Committee on Fetus and Newborn","year":"2012","journal-title":"Pediatrics"},{"key":"pone.0345672.ref003","article-title":"A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever","volume":"10","author":"H An","year":"2022","journal-title":"PeerJ"},{"issue":"7","key":"pone.0345672.ref004","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.3390\/ijms26073259","article-title":"Systemic inflammatory response syndrome, thromboinflammation, and septic shock in fetuses and neonates","volume":"26","author":"V Bitsadze","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pone.0345672.ref005","doi-asserted-by":"crossref","first-page":"100100","DOI":"10.1016\/j.rpth.2023.100100","article-title":"Sepsis-induced coagulopathy in preterm neonates with Gram-positive sepsis presents with hypercoagulation and reduced platelet activation compared with healthy preterm neonates","volume":"7","author":"D Gialamprinou","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"pone.0345672.ref006","doi-asserted-by":"crossref","first-page":"627715","DOI":"10.3389\/fped.2021.627715","article-title":"Hemostatic challenges in neonates","volume":"9","author":"P Davenport","year":"2021","journal-title":"Front Pediatr"},{"issue":"2","key":"pone.0345672.ref007","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.38136\/jgon.1179018","article-title":"Disseminated intravascular coagulation in obstetric patients: maternal and fetal results","volume":"20","author":"\u00d6 Ceylan","year":"2023","journal-title":"Jinekoloji-Obstetrik ve Neonatoloji T\u0131p Dergisi"},{"key":"pone.0345672.ref008","doi-asserted-by":"crossref","first-page":"1364725","DOI":"10.3389\/fped.2024.1364725","article-title":"The frequency and timing of sepsis-associated coagulopathy in the neonatal intensive care unit","volume":"12","author":"KB Aziz","year":"2024","journal-title":"Front Pediatr"},{"key":"pone.0345672.ref009","article-title":"D-dimer in early diagnosis of neonatal sepsis","author":"N Lungu","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"pone.0345672.ref010","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12884-025-07427-0","article-title":"Evaluating predelivery platelet and coagulation indices as predictors of immediate postpartum haemorrhage in low-risk women undergoing vaginal delivery","volume":"25","author":"Y Peng","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"issue":"4","key":"pone.0345672.ref011","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4103\/njcp.njcp_530_24","article-title":"Relationship NLR, SIRI, SII, PIV and fetal growth restriction","volume":"28","author":"A Akay","year":"2025","journal-title":"Niger J Clin Pract"},{"issue":"4","key":"pone.0345672.ref012","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3390\/microorganisms11041010","article-title":"Infection Induced Fetal Inflammatory Response Syndrome (FIRS): state-of- the-art and medico-legal implications-a narrative review","volume":"11","author":"E Giovannini","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"pone.0345672.ref013","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12884-024-06543-7","article-title":"Association of prothrombin time, thrombin time and activated partial thromboplastin time levels with preeclampsia: a systematic review and meta-analysis","volume":"24","author":"E Alemayehu","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"issue":"2","key":"pone.0345672.ref014","doi-asserted-by":"crossref","first-page":"199","DOI":"10.12996\/gmj.2024.4320","article-title":"Exploring the predictive potential of systemic immune inflammation index and hematologic markers in preterm labor risk assessment","volume":"36","author":"S \u00d6zkan","year":"2025","journal-title":"GMJ"},{"issue":"7","key":"pone.0345672.ref015","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.cmi.2024.03.005","article-title":"Diagnostic value of maternal, cord blood and neonatal biomarkers for early-onset sepsis: a systematic review and meta-analysis","volume":"30","author":"LM van Leeuwen","year":"2024","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"pone.0345672.ref016","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00431-017-3072-z","article-title":"Thromboelastometry for diagnosis of neonatal sepsis-associated coagulopathy: an observational study","volume":"177","author":"R Sokou","year":"2018","journal-title":"Eur J Pediatr"},{"issue":"4","key":"pone.0345672.ref017","first-page":"203","article-title":"Measures of diagnostic accuracy: basic definitions","volume":"19","author":"AM \u0160imundi\u0107","year":"2009","journal-title":"EJIFCC"},{"key":"pone.0345672.ref018","doi-asserted-by":"crossref","first-page":"1004727","DOI":"10.3389\/fped.2022.1004727","article-title":"Development and validation of a sepsis diagnostic scoring model for neonates with suspected sepsis","volume":"10","author":"R Sokou","year":"2022","journal-title":"Front Pediatr"},{"issue":"2","key":"pone.0345672.ref019","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/diagnostics12020261","article-title":"Neonatal sepsis and hemostasis","volume":"12","author":"D Gialamprinou","year":"2022","journal-title":"Diagnostics (Basel)"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0345672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:41:28Z","timestamp":1774028488000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0345672"}},"subtitle":[],"editor":[{"given":"Akbar","family":"Dorgalaleh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0345672","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]}}}