{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:08Z","timestamp":1787022188218,"version":"build-2736575974"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-traumatic cutaneous scars enter an immature phase after re-epithelialization, characterized by ongoing inflammation and active remodeling. This phase, typically within six months of injury, may allow preventive interventions before pathological scarring develops. Platelet-rich plasma (PRP) has been suggested as a modulator of scar remodeling due to its growth factor content, but its role in immature scars has not been systematically reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map and summarize the clinical evidence on autologous platelet-containing plasma (ACP), including platelet-rich plasma (PRP), for immature post-traumatic scars and early keloids, and to identify gaps for future research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was performed following established frameworks and reporting guidelines. Databases including PubMed\/MEDLINE, DOAJ, SciELO, LILACS, and Google Scholar were searched. Studies evaluating ACP or PRP applied to post-traumatic scars within six months post-epithelialization were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five studies involving 65 patients met inclusion criteria, including randomized trials, observational studies, and case reports. PRP was mainly delivered via intralesional injection. Evidence suggests PRP may improve clinical scar scores and patient-reported outcomes, with no serious adverse events reported. However, studies were heterogeneous in PRP preparation, dosing, timing, and outcome measures. No study was designed to assess PRP as a preventive monotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence for PRP in immature post-traumatic scars and early keloids is extremely limited and heterogeneous. While preliminary findings indicate potential benefit and safety, current data are insufficient to support routine preventive use. High-quality, prospective studies are needed to determine whether PRP can influence scar remodeling or prevent pathological scarring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0345754","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:27:00Z","timestamp":1775496420000},"page":"e0345754","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet-rich plasma for immature post-traumatic scars and early keloids: A scoping review"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0422-8515","authenticated-orcid":true,"given":"Virgilio","family":"Bland\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2645-5197","authenticated-orcid":true,"given":"Alessandro","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0623-5384","authenticated-orcid":true,"given":"Miguel","family":"Borge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylys","family":"Leyton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5357-9585","authenticated-orcid":true,"given":"Sofia","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"issue":"9","key":"pone.0345754.ref001","doi-asserted-by":"crossref","first-page":"200223","DOI":"10.1098\/rsob.200223","article-title":"Wound healing: cellular mechanisms and pathological outcomes","volume":"10","author":"HN Wilkinson","year":"2020","journal-title":"Open Biol"},{"issue":"1","key":"pone.0345754.ref002","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-023-00474-x","article-title":"Scars","volume":"9","author":"MG Jeschke","year":"2023","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"pone.0345754.ref003","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/ptj\/69.12.1014","article-title":"The biology of scar formation","volume":"69","author":"MA Hardy","year":"1989","journal-title":"Phys Ther"},{"issue":"3","key":"pone.0345754.ref004","article-title":"Spatiotemporal single-cell roadmap of human skin wound healing","volume":"32","author":"Z Liu","year":"2025","journal-title":"Cell Stem Cell"},{"issue":"2","key":"pone.0345754.ref005","first-page":"136","article-title":"Modeling of old scars: histopathological, biochemical and thermal analysis of the scar tissue maturation","volume":"10","author":"A Fayzullin","year":"2021","journal-title":"Biology (Basel)"},{"issue":"7","key":"pone.0345754.ref006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022139","article-title":"Collagen-binding peptidoglycans inhibit MMP mediated collagen degradation and reduce dermal scarring","volume":"6","author":"K Stuart","year":"2011","journal-title":"PLoS One"},{"key":"pone.0345754.ref007","doi-asserted-by":"crossref","first-page":"603187","DOI":"10.3389\/fimmu.2020.603187","article-title":"The roles of inflammation in keloid and hypertrophic scars","volume":"11","author":"Z-C Wang","year":"2020","journal-title":"Front Immunol"},{"key":"pone.0345754.ref008","doi-asserted-by":"crossref","first-page":"883239","DOI":"10.3389\/fimmu.2022.883239","article-title":"Controlling inflammation pre-emptively or at the time of cutaneous injury optimises outcome of skin scarring","volume":"13","author":"S Ud-Din","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"pone.0345754.ref009","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0268-960X(89)90034-9","article-title":"Platelet-derived growth factors","volume":"3","author":"K Miyazono","year":"1989","journal-title":"Blood Rev"},{"issue":"1","key":"pone.0345754.ref010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000477353","article-title":"A review of platelet-rich plasma: history, biology, mechanism of action, and classification","volume":"4","author":"R Alves","year":"2018","journal-title":"Skin Appendage Disord"},{"issue":"11","key":"pone.0345754.ref011","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70374","article-title":"From growth factors to structure: PDGF and TGF-\u03b2 in granulation tissue formation. 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