{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:53:11Z","timestamp":1775069591617,"version":"3.50.1"},"reference-count":10,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"Sickle Cell Disease (SCD) remains a public health challenge in India, particularly among tribal populations. Gaps persist in early detection, awareness, and culturally appropriate interventions, especially among adolescents, a key target group for long-term prevention. The study aims to evaluate the effect of a school-based educational intervention on the awareness, attitude, and early detection of SCD among adolescents in tribal and non-tribal areas of East Singhbhum district, Jharkhand. A sequential explanatory mixed-methods design will be used. In the quantitative phase, adolescents aged 13\u201319 years from selected government schools will undergo baseline and follow-up assessments of knowledge and attitudes using structured questionnaires. A health education session will be delivered, followed by screening for anemia and SCD using hemoglobin estimation and the solubility test. In the qualitative phase, in-depth interviews with stakeholders, including healthcare providers, ASHAs, school staff, caregivers, and affected adolescents, will explore perceptions, barriers, and feedback related to the SCD and National Sickle Cell Anemia Elimination Mission, 2023 implementation. A quasi-experimental one-group pretest-posttest was conducted among 41 adolescents (13\u201315 years) from a government school. Knowledge scores increased from 5.31\u2009\u00b1\u20092.87 to 12.57\u2009\u00b1\u20092.09 (mean difference: 7.26, 95% CI: 6.10\u20138.42, p\u2009<\u20090.001). Attitude scores from 1.44\u2009\u00b1\u20099.21 to 55.83\u2009\u00b1\u20098.42 (mean difference: 54.39, 95% CI: 50.89\u201357.89, p\u2009<\u20090.001). Willingness to undergo SCD testing rose from 37% to 83% post-intervention. Stakeholder feedback indicated high acceptability and enthusiasm for similar sessions. The study will provide critical insights into the effectiveness of adolescent-focused health education in enhancing SCD awareness and screening uptake. It will also highlight disparities between tribal and non- tribal populations and inform policy-level recommendations for targeted, equitable interventions. This research will address gaps in adolescents\u2019 SCD awareness and early detection, contributing to the national goal of SCD elimination through evidence-based, community-embedded strategies.<\/jats:p>\n \n Clinical Trial Registry of India:<\/jats:bold>\n CTRI\/2024\/12\/078542<\/jats:ext-link>\n <\/jats:p>","DOI":"10.1371\/journal.pone.0345849","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:40:41Z","timestamp":1775065241000},"page":"e0345849","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of health educational intervention on early detection of sickle cell disease among adolescent population in tribal areas of East Singhbhum district, Jharkhand: A study protocol"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7872-526X","authenticated-orcid":true,"given":"Sarbasree","family":"Bhattacharjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-6799","authenticated-orcid":true,"given":"Jarina","family":"Begum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjitha S.","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Irfan","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5050-6812","authenticated-orcid":true,"given":"Ravi Ranjhan","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anit","family":"Kujur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Amir","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"8","key":"pone.0345849.ref001","article-title":"Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the Global Burden of Disease Study 2021","volume":"10","author":"GBD 2021 Sickle Cell Disease Collaborators","year":"2023","journal-title":"Lancet Haematol"},{"issue":"23","key":"pone.0345849.ref002","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease -- life expectancy and risk factors for early death","volume":"330","author":"OS Platt","year":"1994","journal-title":"New Engl J Med"},{"issue":"5","key":"pone.0345849.ref003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4103\/0971-5916.159492","article-title":"Sickle cell disease in tribal populations in India","volume":"141","author":"RB Colah","year":"2015","journal-title":"Indian J Med Res"},{"issue":"6","key":"pone.0345849.ref004","article-title":"Prevalence of sickle cell disorder in Jharkhand: a retrospective case study","volume":"9","author":"S Pathak","year":"2020","journal-title":"Glob J Res Anal"},{"issue":"38","key":"pone.0345849.ref005","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000035237","article-title":"Understanding Sickle cell disease: Causes, symptoms, and treatment options","volume":"102","author":"C Elendu","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"pone.0345849.ref006","doi-asserted-by":"crossref","first-page":"18010","DOI":"10.1038\/nrdp.2018.10","article-title":"Sickle cell disease","volume":"4","author":"GJ Kato","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"pone.0345849.ref007","unstructured":"Government of Jharkhand. 2024. Available from: https:\/\/www.jharkhand.gov.in\/home\/AboutTribals"},{"key":"pone.0345849.ref008","doi-asserted-by":"crossref","first-page":"998","DOI":"10.24911\/IJMDC.51-1562400411","article-title":"Sickle cell disease awareness among school children in Saudi Arabia","author":"M Albagshi","year":"2019","journal-title":"IJMDC"},{"issue":"3","key":"pone.0345849.ref009","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12687-024-00706-x","article-title":"Comparative assessment of quality of life among adolescents with sickle cell disease and sickle cell trait: evidence from Odisha, India","volume":"15","author":"BK Bindhani","year":"2024","journal-title":"J Community Genet"},{"issue":"1","key":"pone.0345849.ref010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0296119","article-title":"Prevalence of sickle cell trait and needs assessment for uptake of sickle cell screening among secondary school students in Kampala City, Uganda","volume":"19","author":"S Namukasa","year":"2024","journal-title":"PLoS One"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0345849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:40:44Z","timestamp":1775065244000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0345849"}},"subtitle":[],"editor":[{"given":"Deogratias","family":"Munube","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0345849","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}