{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:07:08Z","timestamp":1774980428079,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Swedish government and the county councils (ALF agreement) from Region \u00d6rebro County"},{"name":"\u00d6rebro County Council Research Committee"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Most studies regarding quality of life in patients with non-functioning pituitary adenoma are based on general questionnaires that might not capture disease-specific aspects, making further exploration of patients\u2019 experiences with non-functioning pituitary adenoma necessary. This study aimed to describe how patients that have undergone surgery due to non-functioning pituitary adenoma experience the effects of the disease on their life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Semi-structured interviews were held with eight participants who had undergone surgery due to non-functioning pituitary adenoma. Participants were recruited from an outpatient endocrinology clinic at a tertiary hospital in Sweden. Inductive qualitative content analysis was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis identified an overarching theme,\n                      <jats:italic>Life has changed but not necessarily for the worse<\/jats:italic>\n                      , and three subthemes:\n                      <jats:italic>The knowledge about the tumour evoked existential concerns<\/jats:italic>\n                      ,\n                      <jats:italic>Suffering became a part of life<\/jats:italic>\n                      and\n                      <jats:italic>Finding comfort in a new everyday life.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings show that the participants\u2019 lives have changed due to non-functioning pituitary adenoma. While this change was not always for the worse, the quality of life was negatively impacted for some, despite optimal treatment. A changed view on life and general trust in the healthcare system could temper the impact of non-functioning pituitary adenoma. Moreover, communication between healthcare professionals and patients remains a central aspect of patients\u2019 experiences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0345909","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:28:52Z","timestamp":1774978132000},"page":"e0345909","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of a non-functioning pituitary adenoma on life \u2013 A qualitative study of patients\u2019 experiences"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-0001","authenticated-orcid":true,"given":"Nasrin","family":"Al-Shamkhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Ed\u00e9n Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Rask","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-8234","authenticated-orcid":true,"given":"Agneta","family":"Anderz\u00e9n-Carlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"4","key":"pone.0345909.ref001","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1530\/EJE-14-0144","article-title":"The incidence rate of pituitary adenomas in western Sweden for the period 2001-2011","volume":"171","author":"A Tj\u00f6rnstrand","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"pone.0345909.ref002","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1530\/EJE-15-0189","article-title":"The epidemiology 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Ung","year":"2019","journal-title":"Endocr Connect"},{"issue":"3","key":"pone.0345909.ref025","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/a-0850-9448","article-title":"Quality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma","volume":"51","author":"G Crouzeix","year":"2019","journal-title":"Horm Metab Res"},{"key":"pone.0345909.ref026","volume-title":"Readme first for a user\u2019s guide to qualitative methods","author":"L Richards","year":"2007","edition":"2"}],"container-title":["PLOS 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