{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:52:33Z","timestamp":1778863953522,"version":"3.51.4"},"reference-count":98,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conahcyt\/Secihti","award":["CF-2023-I-218"],"award-info":[{"award-number":["CF-2023-I-218"]}]},{"name":"UNAM-DGAPA","award":["IN204720"],"award-info":[{"award-number":["IN204720"]}]},{"name":"UNAM-DGAPA","award":["IN213423"],"award-info":[{"award-number":["IN213423"]}]},{"name":"UNAM-DGAPA","award":["IN211326"],"award-info":[{"award-number":["IN211326"]}]},{"name":"SECIHTI","award":["1019538"],"award-info":[{"award-number":["1019538"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Cortical dysplasias are malformations of cortical development characterized by disorganization of the cyto- and myeloarchitecture of the neocortex. They are a common cause of epilepsy and their diagnosis through conventional imaging can often be challenging, hindering surgical treatments. Diffusion-weighted magnetic resonance imaging (dMRI) has the ability to infer tissue properties at the microscopic scale, making it a promising technique for detection of cortical dysplasias. This study aims to assess the microarchitecture of the cerebral cortex in a murine model of cortical dysplasia using dMRI acquired with b-tensor encoding. Pregnant Sprague-Dawley rats were administered either carmustine (BCNU) or saline solution on day 15 of gestation. Their offspring were imaged at 120 days of age using a 7 tesla scanner, acquiring diffusion-sensitive images with b-tensor encoding. Images were processed with Q-space trajectory imaging with positivity constraints (QTI+) to derive various metrics along a curvilinear coordinate system across the neocortex. After scanning, the brains were processed for immunofluorescence and histological examinations. Experimental animals exhibited a significant reduction of microscopic fractional anisotropy (\u00b5FA) and anisotropic kurtosis (K\n                    <jats:sub>shear<\/jats:sub>\n                    ) in the middle and lateral cortical layers compared to the control animals. Immunofluorescence and histological analysis showed decreased and dysorganized myelinated fibers, and an increase of glial processes in BCNU-treated animals. Given the applicability of b-tensor encoding in clinical scanners, this approach holds promise for improving detection of focal cortical dysplasias in patients with epilepsy.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0346132","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:41:26Z","timestamp":1775238086000},"page":"e0346132","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal 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