{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:07:11Z","timestamp":1780988831293,"version":"3.54.1"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["010\/2557"],"award-info":[{"award-number":["010\/2557"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    This work aimed to clarify how polymorphisms in the\n                    <jats:italic>TNF<\/jats:italic>\n                    \u00a0gene relate to metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and a broad spectrum of cardiometabolic characteristics, while also determining their impact on circulating TNF\u2011\u03b1 concentrations. A total of 765 participants were genotyped for rs1800629 and rs361525, and serum TNF-\u03b1 was also measured. To assess these relationships, multivariable logistic regression models\u2014incorporating age, sex, and body mass index (BMI)\u2014were applied to estimate adjusted odds ratios (aORs) and their corresponding 95% confidence intervals (CIs). Both variants were significantly associated with MetS: rs1800629 (crude OR = 2.22, 95% CI: 1.45\u20133.44,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001; adjusted OR = 3.13, 95% CI: 1.78\u20135.06,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) and rs361525 (crude OR = 2.08, 95% CI: 1.07\u20134.21,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.035; adjusted OR = 2.84, 95% CI: 1.17\u20137.31,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.025). The rs1800629 variant was also linked to T2DM risk (adjusted OR = 2.61, 95% CI: 1.35\u20135.24,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.006), whereas rs361525 showed no such association. Carriers of rs1800629 had higher mean TNF-\u03b1 levels (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), with A allele carriers among T2DM patients showing the greatest elevation. Our findings indicate that the rs1800629 and rs361525 variants may contribute meaningfully to MetS susceptibility, and that rs1800629, in particular, shows a notable association with T2DM risk, underscoring its potential relevance in personalized metabolic risk assessment.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0346147","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:45:17Z","timestamp":1775151917000},"page":"e0346147","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of tumor necrosis factor alpha genetic variants with metabolic syndrome and type 2 diabetes mellitus in a Thai population"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0510-1807","authenticated-orcid":true,"given":"Metha","family":"Yaikwawong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanittha","family":"Kamdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasarnchon","family":"Mek-yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7039-4936","authenticated-orcid":true,"given":"Somlak","family":"Chuengsamarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"issue":"2","key":"pone.0346147.ref001","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/ijms23020786","article-title":"Metabolic syndrome: updates on pathophysiology and management in 2021","volume":"23","author":"G Fahed","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"19","key":"pone.0346147.ref002","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.3390\/jcm13195880","article-title":"A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies and Non-Invasive Diagnostic Approaches","volume":"13","author":"F Giangregorio","year":"2024","journal-title":"J Clin Med"},{"issue":"8","key":"pone.0346147.ref003","article-title":"A Comprehensive Review of Metabolic Syndrome and Its Role in Cardiovascular Disease and Type 2 Diabetes Mellitus: Mechanisms, Risk Factors, and Management","volume":"16","author":"RH Dhondge","year":"2024","journal-title":"Cureus"},{"issue":"7","key":"pone.0346147.ref004","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3390\/jcm14072402","article-title":"Developmental Trends of Metabolic Syndrome in the Past Two Decades: A Narrative Review","volume":"14","author":"AA Obeidat","year":"2025","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0346147.ref005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41467-025-67268-5","article-title":"Worldwide trends in metabolic syndrome from 2000 to 2023: a systematic review and modelling analysis","volume":"17","author":"JJ Noubiap","year":"2025","journal-title":"Nat Commun"},{"key":"pone.0346147.ref006","doi-asserted-by":"crossref","first-page":"1333910","DOI":"10.3389\/fpubh.2024.1333910","article-title":"Comparison of metabolic syndrome prevalence and characteristics using five different definitions in China: a population-based retrospective study","volume":"12","author":"K Ma","year":"2024","journal-title":"Front Public Health"},{"issue":"2","key":"pone.0346147.ref007","doi-asserted-by":"crossref","first-page":"70","DOI":"10.51789\/cmsj.2024.4.e14","article-title":"Metabolic syndrome fact sheet 2024: executive report","volume":"4","author":"HJ Kim","year":"2024","journal-title":"Cardiometab Syndr J"},{"key":"pone.0346147.ref008","doi-asserted-by":"crossref","first-page":"5076858","DOI":"10.1155\/2020\/5076858","article-title":"Elevated Serum TNF-\u03b1 Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance","volume":"2020","author":"H Alzamil","year":"2020","journal-title":"J Obes"},{"issue":"5","key":"pone.0346147.ref009","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/ijms22052719","article-title":"The Role of Tumor Necrosis Factor Alpha (TNF-\u03b1) in Autoimmune Disease and Current TNF-\u03b1 Inhibitors in Therapeutics","volume":"22","author":"D-I Jang","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5091","key":"pone.0346147.ref010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"GS Hotamisligil","year":"1993","journal-title":"Science"},{"issue":"6651","key":"pone.0346147.ref011","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/39335","article-title":"Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function","volume":"389","author":"KT Uysal","year":"1997","journal-title":"Nature"},{"issue":"5","key":"pone.0346147.ref012","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance","volume":"95","author":"GS Hotamisligil","year":"1995","journal-title":"J Clin Invest"},{"issue":"5","key":"pone.0346147.ref013","article-title":"Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance","volume":"280","author":"PA Kern","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"pone.0346147.ref014","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2010-1170","article-title":"TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome","volume":"96","author":"TL Stanley","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"pone.0346147.ref015","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1186\/s40064-016-3197-y","article-title":"TNF-\u03b1 gene polymorphisms and expression","volume":"5","author":"RR El-Tahan","year":"2016","journal-title":"Springerplus"},{"issue":"10","key":"pone.0346147.ref016","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00125-005-1902-4","article-title":"Large-scale studies of the association between variation at the TNF\/LTA locus and susceptibility to type 2 diabetes","volume":"48","author":"E Zeggini","year":"2005","journal-title":"Diabetologia"},{"issue":"1","key":"pone.0346147.ref017","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1038\/s41598-021-83321-x","article-title":"-308G\/A polymorphism of tumor necrosis factor alpha (TNF-\u03b1) gene and metabolic syndrome susceptibility: a meta-analysis","volume":"11","author":"D Wang","year":"2021","journal-title":"Sci Rep"},{"issue":"12","key":"pone.0346147.ref018","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3390\/cells12121594","article-title":"Genetic Variations in IL-1\u03b2, TNF-\u03b1, and TGF-\u03b2 Associated with the Severity of Chronic Cervical Spondylitis in Patients","volume":"12","author":"SRM Yadav","year":"2023","journal-title":"Cells"},{"issue":"1","key":"pone.0346147.ref019","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12879-020-4910-6","article-title":"Evaluation of TNF-\u03b1 genetic polymorphisms as predictors for sepsis susceptibility and progression","volume":"20","author":"AM Georgescu","year":"2020","journal-title":"BMC Infect Dis"},{"issue":"9","key":"pone.0346147.ref020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046113","article-title":"Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality","volume":"7","author":"Z Song","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"pone.0346147.ref021","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0021-9150(01)00648-7","article-title":"The TNF\u03b1\/G-308A polymorphism influences insulin sensitivity in offspring of patients with coronary heart disease","volume":"161","author":"V Nicaud","year":"2002","journal-title":"Atherosclerosis"},{"issue":"5","key":"pone.0346147.ref022","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/oby.2002.55","article-title":"Association of the TNF-alpha -308 G\/A promoter polymorphism with insulin resistance in obesity","volume":"10","author":"B Dalziel","year":"2002","journal-title":"Obes Res"},{"issue":"3","key":"pone.0346147.ref023","article-title":"A meta-analysis of the association between TNF-\u03b1 -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population","volume":"8","author":"Z Liu","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"pone.0346147.ref024","first-page":"13739","article-title":"Genetic polymorphisms of the TNF-\u03b1-308G\/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China","volume":"8","author":"Y-H Yang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"pone.0346147.ref025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40200-021-00732-3","article-title":"Association of TNF-alpha-308 G>A (rs1800629) polymorphism with susceptibility of metabolic syndrome","volume":"20","author":"D Ghareeb","year":"2021","journal-title":"J Diabetes Metab Disord"},{"key":"pone.0346147.ref026","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2350-2-10","article-title":"The G-308A variant of the Tumor Necrosis Factor-alpha (TNF-alpha) gene is not associated with obesity, insulin resistance and body fat distribution","volume":"2","author":"S Romeo","year":"2001","journal-title":"BMC Med Genet"},{"issue":"4","key":"pone.0346147.ref027","first-page":"1731","article-title":"The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians","volume":"85","author":"SK Rasmussen","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"pone.0346147.ref028","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.diabres.2003.08.002","article-title":"-308 Nco I polymorphism of tumour necrosis factor alpha in overweight Caucasians","volume":"62","author":"AM Morris","year":"2003","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"pone.0346147.ref029","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/2011\/360312","article-title":"Tumor necrosis factor-alpha gene promoter -308G\/A and -238G\/A polymorphisms in Mexican patients with type 2 diabetes mellitus","volume":"30","author":"JM Guzm\u00e1n-Flores","year":"2011","journal-title":"Dis Markers"},{"issue":"2","key":"pone.0346147.ref030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4067\/S0716-97602008000200005","article-title":"Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population","volume":"41","author":"V Boraska","year":"2008","journal-title":"Biol Res"},{"issue":"5","key":"pone.0346147.ref031","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00109-010-0594-5","article-title":"Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians","volume":"88","author":"A Mahajan","year":"2010","journal-title":"J Mol Med (Berl)"},{"issue":"6","key":"pone.0346147.ref032","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/iji.12698","article-title":"Investigations of associations between TNF-\u03b1 promoter polymorphisms and genetic susceptibility to type 2 diabetes mellitus: A cross-sectional study in Chinese Han population","volume":"51","author":"W Tao","year":"2024","journal-title":"Int J Immunogenet"},{"issue":"11","key":"pone.0346147.ref033","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.26719\/emhj.21.051","article-title":"Incidence of and factors associated with metabolic syndrome, south-east Islamic Republic of Iran","volume":"27","author":"K Farmanfarma","year":"2021","journal-title":"East Mediterr Health J"},{"issue":"9403","key":"pone.0346147.ref034","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"WHO Expert Consultation","year":"2004","journal-title":"Lancet"},{"issue":"5","key":"pone.0346147.ref035","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A note on exact tests of Hardy-Weinberg equilibrium","volume":"76","author":"JE Wigginton","year":"2005","journal-title":"Am J Hum Genet"},{"key":"pone.0346147.ref036","unstructured":"Sinnwell JP, Schaid DJ, Yu Z. haplo. stats: Statistical analysis of haplotypes with traits and covariates when linkage phase is ambiguous. 2007. Available from: http:\/\/mayoresearch.mayo.edu\/mayo\/research\/schaid_lab\/software.cfm"},{"issue":"14","key":"pone.0346147.ref037","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.7314\/APJCP.2014.15.14.5895","article-title":"Association of polymorphisms in stress-related TNF\u03b1 and NPY genes with the metabolic syndrome in Han and Hui ethnic groups","volume":"15","author":"D-Y Bu","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"issue":"10","key":"pone.0346147.ref038","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.18632\/aging.101600","article-title":"The influence of the TNF\u03b1 rs1800629 polymorphism on some inflammatory biomarkers in 45-60-year-old women with metabolic syndrome","volume":"10","author":"M Szkup","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"pone.0346147.ref039","first-page":"16","article-title":"The rs1800629 polymorphism of the TNF\u03b1 gene in type 2 diabetes mellitus: association with nephropathy","volume":"15","author":"SV Ziablytsev","year":"2019","journal-title":"Int J Endocrinol (Ukraine)"},{"issue":"2","key":"pone.0346147.ref040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phrp.2015.01.003","article-title":"Association of TNF-\u03b1 308 G\/A Polymorphism With Type 2 Diabetes: A Case\u2013Control Study in the Iranian Kurdish Ethnic Group","volume":"6","author":"H Golshani","year":"2015","journal-title":"Osong Pub Health Res Perspect"},{"key":"pone.0346147.ref041","first-page":"72","article-title":"Association between tumor necrosis factor-alpha-308 G\/A polymorphism and type 2 diabetes mellitus","volume":"10","author":"H Pan","year":"2006","journal-title":"Chin J Clin Rehabil"},{"key":"pone.0346147.ref042","first-page":"271","article-title":"Association between tumor necrosis factor-\u03b1 gene polymorphism and insulin resistance in type 2 diabetes mellitus","volume":"19","author":"R Ren","year":"2003","journal-title":"Chin J Endocrinol Metab"},{"issue":"2","key":"pone.0346147.ref043","first-page":"255","article-title":"Association of UCP3, APN, and TNF-alpha gene polymorphisms with type 2 diabetes in a population of Northern Chinese Han patients","volume":"28","author":"W Ling-ling","year":"2012","journal-title":"Chem Res Chin Univ"},{"issue":"2","key":"pone.0346147.ref044","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181202","article-title":"Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study","volume":"39","author":"U Zafar","year":"2019","journal-title":"Biosci Rep"},{"issue":"2","key":"pone.0346147.ref045","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/jre.12820","article-title":"Association between TNF-\u03b1 G-308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta-analysis","volume":"56","author":"L-X Shi","year":"2021","journal-title":"J Periodontal Res"},{"issue":"5","key":"pone.0346147.ref046","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.metabol.2006.12.013","article-title":"Tumor necrosis factor alpha -238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus","volume":"56","author":"B Fontaine-Bisson","year":"2007","journal-title":"Metabolism"},{"issue":"12","key":"pone.0346147.ref047","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ejcn.2012.156","article-title":"The tumor necrosis factor-\u03b1 gene -238G>A polymorphism, dietary fat intake, obesity risk and serum lipid concentrations in black and white South African women","volume":"66","author":"YT Joffe","year":"2012","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"pone.0346147.ref048","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s13105-011-0084-4","article-title":"Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet","volume":"67","author":"P Cordero","year":"2011","journal-title":"J Physiol Biochem"},{"issue":"4","key":"pone.0346147.ref049","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF Receptor Superfamilies","volume":"104","author":"RM Locksley","year":"2001","journal-title":"Cell"},{"issue":"1","key":"pone.0346147.ref050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jcb.26174","article-title":"Tumor necrosis factor-alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus","volume":"119","author":"MSH Akash","year":"2018","journal-title":"J Cell Biochem"},{"issue":"6","key":"pone.0346147.ref051","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1043-2760(00)00272-1","article-title":"Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes","volume":"11","author":"DE Moller","year":"2000","journal-title":"Trends Endocrinol Metab"},{"issue":"12","key":"pone.0346147.ref052","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1007\/s00125-007-0834-6","article-title":"Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes","volume":"50","author":"P Plomgaard","year":"2007","journal-title":"Diabetologia"},{"key":"pone.0346147.ref053","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.imlet.2017.04.003","article-title":"Serum TNF-\u03b1 concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta-analysis","volume":"186","author":"Y-L Chen","year":"2017","journal-title":"Immunol Lett"},{"issue":"67","key":"pone.0346147.ref054","doi-asserted-by":"crossref","first-page":"111456","DOI":"10.18632\/oncotarget.22824","article-title":"The effects of tumor necrosis factor-\u03b1 (TNF-\u03b1) rs1800629 and rs361525 polymorphisms on sepsis risk","volume":"8","author":"Y Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"19","key":"pone.0346147.ref055","doi-asserted-by":"crossref","first-page":"10590","DOI":"10.3390\/ijms251910590","article-title":"Role of Genetic Polymorphisms -238 G>A and -308 G>A, and Serum TNF-\u03b1 Levels in a Cohort of Mexican Pediatric Neuroblastoma Patients: Preliminary Study","volume":"25","author":"A Ram\u00edrez-Pacheco","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"pone.0346147.ref056","first-page":"364","article-title":"The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and\/or type 1 diabetes mellitus","volume":"15","author":"C P\u00e9rez","year":"2004","journal-title":"Eur Cytokine Netw"},{"issue":"3","key":"pone.0346147.ref057","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3892\/br.2021.1454","article-title":"Promoter polymorphism of TNF-\u03b1 (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population","volume":"15","author":"K Kamdee","year":"2021","journal-title":"Biomed Rep"},{"issue":"7","key":"pone.0346147.ref058","article-title":"Serum tumor necrosis factor alpha (TNF-alpha) levels in obese and overweight adults: correlations with metabolic syndrome and inflammatory markers","volume":"16","author":"S Eswar","year":"2024","journal-title":"Cureus"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0346147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:45:29Z","timestamp":1775151929000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0346147"}},"subtitle":[],"editor":[{"given":"Lai Kuan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0346147","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]}}}