{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:35:36Z","timestamp":1777055736681,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032626","name":"UNITAID","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032626","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is potential demand for pre-exposure prophylaxis (PrEP) in Peru; however, little is known about preferences towards PrEP modalities or the importance of PrEP attributes. Our research focused on which attributes most influence PrEP modalities choice among sexual and gender minorities (SGM). We also assessed how participants\u2019 preferences vary by recruitment strategy and population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a discrete choice experiment (DCE) in three mutually exclusive groups: (1) Implementation PrEP Project (ImPrEP) participants; (2) Sexually transmitted infections (STI) clinic attendees; and (3) Online respondents via social media outreach. PrEP attributes assessed were presentation, frequency of use, healthcare provider, HIV testing frequency, side effects, and efficacy. For the DCE, each participant was presented with 12 pairs of options with mixed attribute levels and had to choose one option per pair. The data were analyzed using choice-based conjoint analysis, employing Hierarchical Bayes estimation techniques to derive individual-level utility scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From June to October 2021, we recruited 2832 participants, with median age of 27 years (IQR\u2009=\u200922\u201333); 56.2% completed tertiary education; and 47.1% earned US$232 or less. In general, efficacy (27.5%, 95% CI 26.9\u201328.1), and frequency of use (21.3%, 95%CI 20.8\u201321.7) were the most important attributes, with the online respondents the highest importance on efficacy (31.9%, 95%CI 31.0\u201332.8). Concerned about potential side effects were more common among STI clinic attendees (17.5% [95%CI: 16.9\u201318.2]) and online respondents (18.8% [95%CI: 18.3\u201319.3]), while the ImPrEP participants placed the greatest importance on the frequency of use [26.7%, 95%CI 25.6\u201327.7].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, attributes such as efficacy and frequency of use were the most important PrEP attributes across the recruitment strategies; however, current ImPrEP participants placed more weight on frequency than the other groups. Our data may be helpful for future PrEP scale-up strategies, anticipating potential users concerns, and learning from current users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0346154","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:39:02Z","timestamp":1777052342000},"page":"e0346154","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Which are the most valued HIV pre-exposure prophylaxis attributes? A discrete choice experiment among sexual and gender minorities in Peru"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-5378","authenticated-orcid":true,"given":"Oliver A.","family":"Elorreaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-2933","authenticated-orcid":true,"given":"Jazmin","family":"Qquellon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelika A.","family":"Konda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino M.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago S.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos F.","family":"Caceres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ImPrEP Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"pone.0346154.ref001","unstructured":"UNAIDS. The path that ends AIDS: UNAIDS Global AIDS Update 2023. 2023 [cited 25 Aug 2023]. Available: https:\/\/www.unaids.org\/en\/resources\/documents\/2023\/global-aids-update-2023"},{"key":"pone.0346154.ref002","unstructured":"UNAIDS. Global data on HIV epidemiology and response - AIDSinfo. 2025 [cited 27 Oct 2025]. Available: https:\/\/aidsinfo.unaids.org\/"},{"key":"pone.0346154.ref003","unstructured":"UNAIDS. Key Population Atlas. 2023 [cited 28 Aug 2023]. Available: kpatlas.unaids.org\/dashboard"},{"key":"pone.0346154.ref004","volume-title":"Pre-exposure prophylaxis for men who have sex with men: a systematic review. 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Event-driven oral pre-exposure prophylaxis to prevent HIV for men who have sex with men: Update to WHO\u2019s recommendation on oral PrEP","author":"WHO","year":"2019"},{"key":"pone.0346154.ref014","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11904-019-00450-9","article-title":"Current and Future PrEP Medications and Modalities: On-demand, Injectables, and Topicals","volume":"16","author":"MR Beymer","year":"2019","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"11","key":"pone.0346154.ref015","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3018(19)30238-3","article-title":"Pre-exposure prophylaxis 2.0: new drugs and technologies in the pipeline","volume":"6","author":"LE Coelho","year":"2019","journal-title":"Lancet HIV"},{"key":"pone.0346154.ref016","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1056\/NEJMoa2101016","article-title":"Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women","volume":"385","author":"RJ Landovitz","year":"2021","journal-title":"N Engl J Med"},{"key":"pone.0346154.ref017","unstructured":"World Health Organization. WHO recommends long-acting cabotegravir for HIV prevention. 2022 [cited 13 May 2024]. Available: https:\/\/www.who.int\/news\/item\/28-07-2022-who-recommends-long-acting-cabotegravir-for-hiv-prevention"},{"issue":"13","key":"pone.0346154.ref018","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1056\/NEJMoa2407001","article-title":"Twice-Yearly Lenacapavir or Daily F\/TAF for HIV Prevention in Cisgender Women","volume":"391","author":"L-G Bekker","year":"2024","journal-title":"N Engl J Med"},{"key":"pone.0346154.ref019","unstructured":"Long-acting injectable lenacapavir continues to show promising results for HIV prevention. [cited 5 Mar 2025]. 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A systematic review and meta-analysis of external validity","volume":"19","author":"M Quaife","year":"2018","journal-title":"Eur J Health Econ"},{"key":"pone.0346154.ref037","article-title":"Who prefers what? Correlates of preferences for next-generation HIV prevention products among a national U.S. sample of young men who have sex with men","author":"KB Biello","year":"2023","journal-title":"J Int AIDS Soc"},{"issue":"3","key":"pone.0346154.ref038","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1097\/QAI.0000000000002670","article-title":"Long-Acting Injection and Implant Preferences and Trade-Offs for HIV Prevention Among South African Male Youth","volume":"87","author":"ET Montgomery","year":"2021","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"6","key":"pone.0346154.ref039","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25528","article-title":"Preferences for long-acting Pre-Exposure Prophylaxis (PrEP) for HIV prevention among South African youth: results of a discrete choice experiment","volume":"23","author":"AM Minnis","year":"2020","journal-title":"J Int AIDS Soc"},{"issue":"11","key":"pone.0346154.ref040","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3018(24)00242-X","article-title":"Cost-effectiveness of lenacapavir for PrEP in Africa","volume":"11","author":"DJ Davey","year":"2024","journal-title":"Lancet HIV"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0346154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:39:12Z","timestamp":1777052352000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0346154"}},"subtitle":[],"editor":[{"given":"Hamufare Dumisani","family":"Mugauri","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0346154","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}