{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:08:54Z","timestamp":1774980534582,"version":"3.50.1"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background\/Aims<\/jats:title>\n Rehospitalization is an important indicator of disease burden and healthcare utilization in inflammatory bowel disease (IBD), yet real-world data from Germany remain scarce. This study aimed to describe 12\u2011month rehospitalization rates after IBD\u2011related inpatient treatment in Germany and to identify administrative and clinical factors recorded in hospital ICD\u201110 coding that are associated with rehospitalization.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this multicenter retrospective cohort study, anonymized administrative data from 49 German hospitals (Section 21 dataset, 2019\u20132023) were analyzed. Patients hospitalized with a primary diagnosis of Crohn\u2019s disease (ICD-10 K50) or ulcerative colitis (ICD-10 K51) were included. The primary endpoint was any rehospitalization within 12 months after the index admission. Univariable and multivariable logistic regression models were used to determine factors of rehospitalization.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 3,202 patients were included (51.3% Crohn\u2019s disease, 48.7% ulcerative colitis; mean age 44.2 years; 50.1% female). The 12-month rehospitalization rate was 22.6%, with a median time of 92 days (IQR 61\u2013184). Independent factors in adjusted analyses were admission to a surgical department (AOR 1.79), peritoneal adhesions (AOR 1.98), type 2 diabetes mellitus (AOR 1.54), and hypokalemia (AOR 1.30). Age, sex, and IBD subtype showed no association.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Using administrative hospital data, we identified several ICD-10\u2013coded comorbidities and treatment characteristics associated with higher rehospitalization rates. These findings highlight subgroups that may benefit from improved post-discharge management, although clinical interpretation is limited by the administrative nature of the dataset.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0346270","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:32:31Z","timestamp":1774978351000},"page":"e0346270","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twelve\u2011month rehospitalization after IBD\u2011related hospitalization in Germany: A retrospective cohort study using administrative hospital data"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-0232","authenticated-orcid":true,"given":"Christian","family":"Weigel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven H.","family":"Loosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaneschka","family":"Yaqubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-8821","authenticated-orcid":true,"given":"Tom","family":"Luedde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Roderburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7227","authenticated-orcid":true,"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"3","key":"pone.0346270.ref001","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cgh.2024.06.049","article-title":"The cost of inflammatory bowel disease care: How to make it sustainable","volume":"23","author":"J Burisch","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"pone.0346270.ref002","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: A systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"R Wang","year":"2023","journal-title":"BMJ Open"},{"issue":"1","key":"pone.0346270.ref003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"GBD 2017 Inflammatory Bowel Disease Collaborators","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8","key":"pone.0346270.ref004","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.14309\/ajg.0000000000002687","article-title":"Forecasting the incidence and prevalence of inflammatory bowel disease: A canadian nationwide analysis","volume":"119","author":"S Coward","year":"2024","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"pone.0346270.ref005","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S2468-1253(23)00003-1","article-title":"The cost of inflammatory bowel disease in high-income settings: A Lancet Gastroenterology & Hepatology Commission","volume":"8","author":"J Burisch","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"pone.0346270.ref006","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjac190.0546","article-title":"P416 The impact of remission on healthcare resource utilisation and costs amongst patients with inflammatory bowel disease in France, Germany, Italy, Spain, and the United Kingdom","volume":"17","author":"KV Patel","year":"2023","journal-title":"Journal of Crohn\u2019s and Colitis"},{"issue":"1","key":"pone.0346270.ref007","doi-asserted-by":"crossref","first-page":"34","DOI":"10.34172\/mejdd.2022.253","article-title":"Risk factors affecting 90-day readmission of patients with inflammatory bowel disease","volume":"14","author":"S Ghahramani","year":"2022","journal-title":"Middle East J Dig Dis"},{"issue":"12","key":"pone.0346270.ref008","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.cgh.2018.08.052","article-title":"Project sonar: A community practice-based intensive medical home for patients with inflammatory bowel diseases","volume":"16","author":"S Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"pone.0346270.ref009","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2018.02.015","article-title":"Annual burden and costs of hospitalization for high-need, high-cost patients with chronic gastrointestinal and liver diseases","volume":"16","author":"NH Nguyen","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"pone.0346270.ref010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2019.08.042","article-title":"Rate of risk factors for and interventions to reduce hospital readmission in patients with inflammatory bowel diseases","volume":"18","author":"NH Nguyen","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"pone.0346270.ref011","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1572-0241.2006.00330.x","article-title":"Hospitalization, surgery, and readmission rates of IBD in Canada: A population-based study","volume":"101","author":"CN Bernstein","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"pone.0346270.ref012","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1097\/MIB.0000000000001242","article-title":"Inflammatory bowel disease: Predictors and causes of early and late hospital readmissions","volume":"23","author":"P Mudireddy","year":"2017","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"pone.0346270.ref013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182900","article-title":"Factors associated with readmission to the hospital within 30 days in patients with inflammatory bowel disease","volume":"12","author":"D Micic","year":"2017","journal-title":"PLoS One"},{"key":"pone.0346270.ref014","doi-asserted-by":"crossref","first-page":"1756284820923836","DOI":"10.1177\/1756284820923836","article-title":"Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: A 16-year nationwide study","volume":"13","author":"M Santiago","year":"2020","journal-title":"Ther Adv Gastroenterol"},{"issue":"6","key":"pone.0346270.ref015","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/MIB.0000000000001121","article-title":"Modifiable risk factors for hospital readmission among patients with inflammatory bowel disease in a nationwide Database","volume":"23","author":"EL Barnes","year":"2017","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"pone.0346270.ref016","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/MIB.0000000000001213","article-title":"Predictors of early readmission in hospitalized patients with inflammatory bowel disease","volume":"23","author":"KE Christian","year":"2017","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"pone.0346270.ref017","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jcsm.13341","article-title":"Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study","volume":"14","author":"Y Zhang","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"pone.0346270.ref018","doi-asserted-by":"crossref","first-page":"367","DOI":"10.21037\/atm-22-1126","article-title":"Sarcopenia is associated with poor clinical outcomes in patients with inflammatory bowel disease: A prospective cohort study","volume":"10","author":"S Liu","year":"2022","journal-title":"Ann Transl Med"},{"issue":"4","key":"pone.0346270.ref019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2018.07.004","article-title":"Obesity is independently associated with higher annual burden and costs of hospitalization in patients with inflammatory bowel diseases","volume":"17","author":"NH Nguyen","year":"2019","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0346270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:32:35Z","timestamp":1774978355000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0346270"}},"subtitle":[],"editor":[{"given":"Marwan Salih","family":"Al-Nimer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0346270","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}