{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:18:57Z","timestamp":1783621137782,"version":"3.55.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022J01682"],"award-info":[{"award-number":["2022J01682"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Key Specialty Construction Project of Fujian Province","award":["2022-884"],"award-info":[{"award-number":["2022-884"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood gas parameters are associated with sepsis prognosis. This study aimed to develop an assessment model based on blood gas parameters for predicting patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were retrospectively extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) and electronic Intensive Care Unit Collaborative Research Database (eICU-CRD). A sepsis assessment model was developed using the MIMIC-IV cohort, followed by internal validation in patients with septic shock from the same database and external validation in patients with sepsis from the eICU-CRD. Bioinformatics and machine learning clarified the relationship between the model and the primary outcome of 28-day mortality in patients with sepsis and septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sepsis assessment blood gas 3 (SABG-3), an assessment model incorporating PO\n                      <jats:sub>2<\/jats:sub>\n                      , base excess (BE), and lactate, was developed and validated as an independent predictor of 28-day mortality in patients with MIMIC-IV sepsis (odds ratio: 1.559; 95% confidence interval: 1.464\u20131.659;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Its prognostic performance was internally validated in patients with MIMIC-IV sepsis and externally validated in patients with eICU-CRD sepsis. High-risk patients identified by SABG-3 exhibited greater illness severity than low-risk ones. Sensitivity analyses across five methods confirmed the prognostic value of SABG-3 for intensive care unit patients with sepsis and septic shock. A SABG-3-derived nomogram proved superior to existing scales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed and validated a novel assessment model and nomogram to evaluate sepsis prognosis rapidly and to identify patients who may benefit from intensified treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0346532","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:39:01Z","timestamp":1783618741000},"page":"e0346532","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A blood gas parameter\u2013based assessment model for predicting poor prognosis in sepsis: A retrospective analysis of the MIMIC-IV and eICU-CRD"],"prefix":"10.1371","volume":"21","author":[{"given":"Xiao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichang","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-2648","authenticated-orcid":true,"given":"Xian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"issue":"1","key":"pone.0346532.ref001","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41392-021-00816-9","article-title":"Signaling 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