{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:28:06Z","timestamp":1775845686111,"version":"3.50.1"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K13875"],"award-info":[{"award-number":["25K13875"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In Japan, end-of-life care in intensive care units (ICU) remains inconsistent and often suboptimal, contributing to variability in the quality of dying and death. This study aimed to develop a culturally appropriate nurse-led intervention program to improve the quality of dying and death in Japanese ICU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a structured framework for intervention development, we conducted a systematic and scoping review to identify modifiable factors and effective strategies for end-of-life care in ICUs. Eight evidence-based strategies were synthesized into four core components: symptom management, multidisciplinary bedside conferences, family conferences, and end-of-life care. A preliminary intervention program was developed and evaluated through expert interviews and web-based surveys to assess its clarity, feasibility, and alignment with the Japanese healthcare system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on expert feedback, revisions were made to enhance the clarity, feasibility, and alignment with the Japanese healthcare system. Key improvements included initiating symptom management early upon ICU admission, allowing flexible scheduling of conferences, and incorporating structured tools and frameworks commonly used in Japan. Additionally, a ladder-based system was introduced to tailor the intervention intensity according to the patients\u2019 clinical conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The final nurse-led intervention program was designed to facilitate more consistent delivery of end-of-life care in the ICU regardless of individual providers\u2019 knowledge or attitudes. This study demonstrates a rigorous and culturally adapted intervention development process that may serve as a model for improving end-of-life care in ICU in Japan and other healthcare systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0346585","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:41:46Z","timestamp":1775842906000},"page":"e0346585","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and external validity of a nurse-led intervention program to improve palliative care and quality of dying and death in intensive care 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