{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:27:00Z","timestamp":1775845620637,"version":"3.50.1"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21764016"],"award-info":[{"award-number":["21764016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    The water-soluble gadolinium fullerenes Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles as a novel magnetic resonance imaging (MRI) contrast agent were fabricated by the metal fullerenes Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    assembled with tetraethylene glycol (TEG). The loading Gd amount in Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles was 8.0 wt%. The average particle size of water-soluble Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles was 97 nm and the nanoparticles were uniformly spherical shape and had good dispersibility and no aggregation. The 97 nm spherical shape of Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEG nanoparticles ensured high relaxivity. The proton relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                    <\/jats:sub>\n                    ) and transverse relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    ) were high up to 37.1 mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7s\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 64.9 mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , which greater than that of commercial Magnevist under the same conditions. The Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles exhibited pronounced\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                    <\/jats:sub>\n                    -weighted MRI\n                    <jats:italic>in vitro<\/jats:italic>\n                    . The MRI signal-enhancing efficiency of Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles was superior to that of gadolinium diethylenetriamine pentaacetate Gd-DTPA (Magnevist). The Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles had no significant effect on cell metabolism and structure, and the survival rate of cells was more than 80%, which indicated that the as-prepared Gd@C\n                    <jats:sub>82<\/jats:sub>\n                    -TEGs nanoparticles were no cytotoxicity.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0346592","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:40:13Z","timestamp":1775842813000},"page":"e0346592","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Water-soluble gadolinium fullerenes Gd@C82-TEGs as a potential magnetic resonance imaging contrast 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