{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:58:33Z","timestamp":1792799913814,"version":"4.5.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education Malaysia","doi-asserted-by":"crossref","award":["600-RMI\/LRGS 5\/3 (2\/2011)-2"],"award-info":[{"award-number":["600-RMI\/LRGS 5\/3 (2\/2011)-2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education Malaysia","doi-asserted-by":"crossref","award":["600-RMI\/LRGS 5\/3 (2\/2011)-2"],"award-info":[{"award-number":["600-RMI\/LRGS 5\/3 (2\/2011)-2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Hypertension (HT) is a \u2018by-product\u2019 to the forces of natural selection against environmental drift and salt availability, therefore contributed to differential HT susceptibility. This study provides further supporting evidence through: (i) associating three salt-sensitive related candidate gene variants, to the susceptibility of HT among the Malays from Peninsular Malaysia with a detail genotype-phenotype evaluation; (ii) comparing the blood pressure and the frequency spectrums of these variants across global populations; (iii) correlating them with the geographical coordinates and BP of the respective populations, and evaluating the presence of local adaptation in these candidate variants. We tested the genetic association of six SNPs underlying\n                    <jats:italic>CYP11B2<\/jats:italic>\n                    ,\n                    <jats:italic>AGT<\/jats:italic>\n                    and\n                    <jats:italic>ADRB2<\/jats:italic>\n                    in 918 normotensives and hypertensives Malays, men and women.\n                    <jats:italic>CYP11B2<\/jats:italic>\n                    and\n                    <jats:italic>ADRB2<\/jats:italic>\n                    were associated with elevated BP in males and females, respectively. Evaluation of these gene variations across 38 populations residing in different latitudinal clines revealed strong correlations between\n                    <jats:italic>CYP11B2<\/jats:italic>\n                    ,\n                    <jats:italic>AGT<\/jats:italic>\n                    and latitudinal coordinates; whilst\n                    <jats:italic>ADRB2<\/jats:italic>\n                    to a weaker extent. Tajima\u2019s D analyses suggested a non-neutral evolution on\n                    <jats:italic>CYP11B2<\/jats:italic>\n                    , which suggested a modest putative signals of local adaptation. In summary, we complement the notion that effective pharmacogenetic marker(s) to predict responsiveness of anti-HT medication requires comprehensive characterization of population genetics and HT phenotypes.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0346614","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:59:13Z","timestamp":1776275953000},"page":"e0346614","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Association of the Renin-Angiotensin-Aldosterone System with hypertension among the Malays and their adaptation to climate change"],"prefix":"10.1371","volume":"21","author":[{"given":"Nur 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