{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:00:15Z","timestamp":1781200815023,"version":"3.54.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Large bone defects require bioactive, mechanically robust scaffolds for regeneration. This study developed 3D-printed polycaprolactone\/biphasic calcium phosphate (PCL\/BCP) composite scaffolds (35\u221245 wt% ion-doped BCP with Sr\n                    <jats:sup>2+<\/jats:sup>\n                    , Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , and Si\n                    <jats:sup>4+<\/jats:sup>\n                    ) via fused deposition modeling (FDM), followed by in situ ZIF-8 coating. The optimal PCL\u2009+\u200940 wt.% ion-doped BCP formulation exhibited superior compressive strength (~30 MPa) and modulus (~ 0.4 GPa). Degradation in Phosphate-buffered saline (PBS) showed ~8% mass loss over 28 days with stable pH. Immersion in simulated body fluid (SBF) revealed rapid apatite formation and sustained release of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , P, Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , Si\n                    <jats:sup>4+<\/jats:sup>\n                    , and Sr\n                    <jats:sup>2+<\/jats:sup>\n                    \u2009ions. SEM confirmed uniform nanoscale ZIF-8 deposition, enriching surfaces with Zn\n                    <jats:sup>2+<\/jats:sup>\n                    . In vitro assays with MG-63 cells and hBMSCs demonstrated that ZIF-8-coated scaffolds significantly enhanced cell adhesion, proliferation (MTT), cytoskeletal organization (DAPI\/phalloidin), and mineralization (Alizarin Red S) compared to uncoated controls (p\u2009&lt;\u20090.05). The synergistic integration of ion-doped BCP, 3D printing, and ZIF-8 coating yields a bioactive, biodegradable platform with excellent osteogenic potential for advanced bone tissue engineering.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0347048","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:25:48Z","timestamp":1781198748000},"page":"e0347048","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["ZIF-8-coated 3D-printed PCL\/ion-doped BCP scaffolds for enhanced bone regeneration"],"prefix":"10.1371","volume":"21","author":[{"given":"Vahid Khademi","family":"Ardakani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Boroumand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0405-8424","authenticated-orcid":true,"given":"Ghasem","family":"Dini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Golabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Abdollahi","family":"Asl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"issue":"9","key":"pone.0347048.ref001","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-Osteoclast Communication and Bone 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