{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:03:01Z","timestamp":1776708181026,"version":"3.51.2"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Traditional Chinese Medicine Expert Inheritance Studio Construction Project","award":["Document No. [2022] 75 from the National Administration of Traditional Chinese Medicine"],"award-info":[{"award-number":["Document No. [2022] 75 from the National Administration of Traditional Chinese Medicine"]}]},{"name":"the Scientific Research Plan Project of the Health Commission of Hunan Province","award":["Grant No. C202303078160"],"award-info":[{"award-number":["Grant No. C202303078160"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["Grant No. 2026JJ81855"],"award-info":[{"award-number":["Grant No. 2026JJ81855"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Histone deacetylases (HDACs) regulate neuroprotection; however, Trichostatin A (TSA), an HDAC inhibitor, lacks clear molecular mechanisms and core targets in Alzheimer\u2019s disease (AD), limiting clinical translation. This study aimed to decipher TSA\u2019s AD-regulating network, screen core genes, and support AD early diagnosis and multi-target therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TSA targets were computationally predicted. Five GEO AD datasets were analyzed for differential genes and core modules, and 130 machine learning algorithms were employed to identify core genes. Functional annotation, immune cell analysis, and single-cell expression profiling were conducted. Molecular docking and 100 ns molecular dynamics simulations verified TSA-protein interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>949 potential TSA targets were identified, overlapping with AD differential genes and enriching key pathways such as GABAergic synapse and tau phosphorylation. Eight machine learning-identified core genes (EFNA1, GABRB2, GABARAPL1, EGR1, CDK5, KCNC2, MET, GRIA2) exhibited a distinct AD expression pattern: synergistic downregulation of protective genes and unique upregulation of pathological EFNA1. These genes are implicated in neurotransmission, synaptic plasticity, tau clearance, and immune-neural crosstalk. Molecular dynamics simulations suggested TSA may not stably bind these candidates, implying its regulation relies on epigenetic mechanisms via HDAC1\u20133\/6 inhibition, potentially restoring gene network balance and disrupting neuroinflammation-neurodegeneration cycles. Complex regulatory modes and cell type-specific expression were also observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides preliminary insights into TSA\u2019s putative mechanisms in AD intervention, highlighting the eight candidate core genes\u2019 potential diagnostic and therapeutic value as AD biomarkers, supporting TSA\u2019s multi-target therapy. All findings are computationally derived and require experimental verification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0347532","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:31:03Z","timestamp":1776706263000},"page":"e0347532","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering the molecular network of Trichostatin A in regulating Alzheimer\u2019s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation"],"prefix":"10.1371","volume":"21","author":[{"given":"Changze","family":"Ou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-3943","authenticated-orcid":true,"given":"Huajun","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"pone.0347532.ref001","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb05964.x","article-title":"Histone deacetylases: unique players in shaping the epigenetic histone code","volume":"983","author":"S Thiagalingam","year":"2003","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"pone.0347532.ref002","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00425-024-04518-8","article-title":"Advances in understanding the roles of plant HAT and HDAC in non-histone protein acetylation and deacetylation","volume":"260","author":"Z Zhang","year":"2024","journal-title":"Planta"},{"issue":"1","key":"pone.0347532.ref003","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2174\/1570159X19666210609160017","article-title":"Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective","volume":"20","author":"V Kumar","year":"2022","journal-title":"Curr Neuropharmacol"},{"issue":"10","key":"pone.0347532.ref004","article-title":"HDACs and HDAC Inhibitors in Cancer Development and Therapy","volume":"6","author":"Y Li","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"pone.0347532.ref005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/bs.pmbts.2023.02.011","article-title":"Histone deacetylase (HDACs) inhibitors: Clinical applications","volume":"198","author":"KD Shanmukha","year":"2023","journal-title":"Prog Mol Biol Transl Sci"},{"key":"pone.0347532.ref006","doi-asserted-by":"crossref","first-page":"107410","DOI":"10.1016\/j.phrs.2024.107410","article-title":"Role of histone deacetylases and their inhibitors in neurological diseases","volume":"208","author":"L-Y Zhang","year":"2024","journal-title":"Pharmacol Res"},{"key":"pone.0347532.ref007","doi-asserted-by":"crossref","first-page":"177520","DOI":"10.1016\/j.ejphar.2025.177520","article-title":"Exploring Alzheimer\u2019s disease treatment: Established therapies and novel strategies for future care","volume":"998","author":"U Soni","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"pone.0347532.ref008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.lfs.2014.01.064","article-title":"Trichostatin A increases the levels of plasma gelsolin and amyloid beta-protein in a transgenic mouse model of Alzheimer\u2019s disease","volume":"99","author":"W Yang","year":"2014","journal-title":"Life Sci"},{"key":"pone.0347532.ref009","doi-asserted-by":"crossref","first-page":"1333235","DOI":"10.3389\/fphar.2024.1333235","article-title":"Trichostatin A relieves anxiety-and depression-like symptoms in APP\/PS1 mice","volume":"15","author":"Q Su","year":"2024","journal-title":"Front Pharmacol"},{"issue":"1","key":"pone.0347532.ref010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13195-020-00746-8","article-title":"Trichostatin A ameliorates Alzheimer\u2019s disease-related pathology and cognitive deficits by increasing albumin expression and A\u03b2 clearance in APP\/PS1 mice","volume":"13","author":"Q Su","year":"2021","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"pone.0347532.ref011","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1570159X13666151021111609","article-title":"Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration","volume":"14","author":"SA Ganai","year":"2016","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"pone.0347532.ref012","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00221-012-3172-y","article-title":"Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer\u2019s disease","volume":"221","author":"J Vadnal","year":"2012","journal-title":"Exp Brain Res"},{"key":"pone.0347532.ref013","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab1112","article-title":"Database resources of the national center for biotechnology information","volume":"50","author":"EW Sayers","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"pone.0347532.ref014","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkad1004","article-title":"The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods","volume":"52","author":"B Zdrazil","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"pone.0347532.ref015","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"A Daina","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"pone.0347532.ref016","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"X Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0347532.ref017","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING database in 2025: protein networks with directionality of regulation","volume":"53","author":"D Szklarczyk","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"pone.0347532.ref018","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Y Liu","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pone.0347532.ref019","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac087","article-title":"FitDock: protein-ligand docking by template fitting","volume":"23","author":"X Yang","year":"2022","journal-title":"Brief Bioinform"},{"key":"pone.0347532.ref020","article-title":"DisGeNet: a disease-centric interaction database among diseases and various associated genes","volume":"2025","author":"Y Hu","year":"2025","journal-title":"Database"},{"issue":"18","key":"pone.0347532.ref021","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","article-title":"DSigDB: drug signatures database for gene set analysis","volume":"31","author":"M Yoo","year":"2015","journal-title":"Bioinformatics"},{"issue":"5","key":"pone.0347532.ref022","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3390\/genes11050556","article-title":"Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability","volume":"11","author":"G Milazzo","year":"2020","journal-title":"Genes (Basel)"},{"issue":"9","key":"pone.0347532.ref023","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1177\/1535370221989263","article-title":"Influence of glutamate and GABA transport on brain excitatory\/inhibitory balance","volume":"246","author":"SM Sears","year":"2021","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"pone.0347532.ref024","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00702-011-0688-4","article-title":"Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells","volume":"119","author":"M Bence","year":"2012","journal-title":"J Neural Transm (Vienna)"},{"issue":"1","key":"pone.0347532.ref025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer\u2019s Disease: Current Progress in Molecular Signaling and Therapeutics","volume":"46","author":"S Thakur","year":"2023","journal-title":"Inflammation"},{"issue":"9","key":"pone.0347532.ref026","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s11064-021-03367-1","article-title":"Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor","volume":"46","author":"N Takada","year":"2021","journal-title":"Neurochem Res"},{"issue":"1","key":"pone.0347532.ref027","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s43141-021-00224-0","article-title":"GABAA receptors: structure, function, pharmacology, and related disorders","volume":"19","author":"A Ghit","year":"2021","journal-title":"J Genet Eng Biotechnol"},{"issue":"1","key":"pone.0347532.ref028","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/dneu.22645","article-title":"Disruption of MET Receptor Tyrosine Kinase, an Autism Risk Factor, Impairs Developmental Synaptic Plasticity in the Hippocampus","volume":"79","author":"X Ma","year":"2019","journal-title":"Dev Neurobiol"},{"issue":"7","key":"pone.0347532.ref029","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41386-018-0034-8","article-title":"Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence","volume":"43","author":"JP Bohnsack","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"pone.0347532.ref030","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223648","article-title":"Expression and interaction proteomics of GluA1- and GluA3-subunit-containing AMPARs reveal distinct protein composition","volume":"11","author":"S van der Spek","year":"2022","journal-title":"Cells"},{"issue":"1","key":"pone.0347532.ref031","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40035-022-00302-4","article-title":"Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer\u2019s disease","volume":"11","author":"D Chen","year":"2022","journal-title":"Transl Neurodegener"},{"issue":"6","key":"pone.0347532.ref032","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s11010-023-04800-5","article-title":"A new perspective on the autophagic and non-autophagic functions of the GABARAP protein family: a potential therapeutic target for human diseases","volume":"479","author":"J Chen","year":"2024","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"pone.0347532.ref033","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.4103\/1673-5374.360165","article-title":"Cdk5 and aberrant cell cycle activation at the core of neurodegeneration","volume":"18","author":"R Requejo-Aguilar","year":"2023","journal-title":"Neural Regen Res"},{"issue":"5","key":"pone.0347532.ref034","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.3390\/ijerph20054540","article-title":"Increased Expression of Autophagy-Related Genes in Alzheimer\u2019s Disease-Type 2 Diabetes Mellitus Comorbidity Models in Cells","volume":"20","author":"C Vianello","year":"2023","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"pone.0347532.ref035","article-title":"The fate of interneurons, GABAA receptor sub-types and perineuronal nets in Alzheimer\u2019s disease","volume":"33","author":"AB Ali","year":"2023","journal-title":"Brain Pathol"},{"issue":"3","key":"pone.0347532.ref036","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307776121","article-title":"A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction","volume":"121","author":"J Clatot","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0347532.ref037","article-title":"Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer\u2019s","volume":"11","author":"VJ Olah","year":"2022","journal-title":"Elife"},{"issue":"1","key":"pone.0347532.ref038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.117.242446","article-title":"Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons","volume":"363","author":"JP Bohnsack","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"issue":"14","key":"pone.0347532.ref039","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1523\/JNEUROSCI.3162-12.2013","article-title":"Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons","volume":"33","author":"JE Hanson","year":"2013","journal-title":"J Neurosci"},{"issue":"4","key":"pone.0347532.ref040","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/bpa.12688","article-title":"Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer\u2019s disease","volume":"29","author":"Y-T Hu","year":"2019","journal-title":"Brain Pathol"},{"issue":"1","key":"pone.0347532.ref041","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s13046-021-02150-y","article-title":"Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma","volume":"40","author":"C Lanzi","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"pone.0347532.ref042","doi-asserted-by":"crossref","first-page":"683609","DOI":"10.3389\/fcell.2021.683609","article-title":"HGF and MET: From Brain Development to Neurological Disorders","volume":"9","author":"C Desole","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"pone.0347532.ref043","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1161\/ATVBAHA.109.193821","article-title":"Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription","volume":"30","author":"B Wang","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"pone.0347532.ref044","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/carcin\/bgw015","article-title":"Regulation of the MET oncogene: molecular mechanisms","volume":"37","author":"J Zhang","year":"2016","journal-title":"Carcinogenesis"},{"issue":"1","key":"pone.0347532.ref045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13024-023-00632-5","article-title":"The Q\/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer\u2019s disease","volume":"18","author":"AL Wright","year":"2023","journal-title":"Mol Neurodegener"},{"key":"pone.0347532.ref046","doi-asserted-by":"crossref","first-page":"174310","DOI":"10.1016\/j.ejphar.2021.174310","article-title":"NMDA and AMPA receptors dysregulation in Alzheimer\u2019s disease","volume":"908","author":"P Babaei","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"pone.0347532.ref047","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11010-016-2764-4","article-title":"Nurr1 and PPAR\u03b3 protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment","volume":"420","author":"M Jodeiri Farshbaf","year":"2016","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"pone.0347532.ref048","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11010088","article-title":"HAT- and HDAC-targeted protein acetylation in the occurrence and treatment of epilepsy","volume":"11","author":"J Wang","year":"2022","journal-title":"Biomedicines"},{"issue":"5","key":"pone.0347532.ref049","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ajpath.2012.06.043","article-title":"Eph\/Ephrin signaling in injury and inflammation","volume":"181","author":"MG Coulthard","year":"2012","journal-title":"Am J Pathol"},{"issue":"48","key":"pone.0347532.ref050","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1415589111","article-title":"Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy","volume":"111","author":"PM McLendon","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0347532.ref051","doi-asserted-by":"crossref","first-page":"763831","DOI":"10.3389\/fimmu.2021.763831","article-title":"The Role of HDAC6 in Autophagy and NLRP3 Inflammasome","volume":"12","author":"P Chang","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"pone.0347532.ref052","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12672-023-00664-9","article-title":"Targeting EFNA1 suppresses tumor progression via the cMYC-modulated cell cycle and autophagy in esophageal squamous cell carcinoma","volume":"14","author":"H Jiang","year":"2023","journal-title":"Discov Oncol"},{"issue":"7","key":"pone.0347532.ref053","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ddr.21340","article-title":"Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy","volume":"77","author":"S Karsli-Ceppioglu","year":"2016","journal-title":"Drug Dev Res"},{"issue":"2","key":"pone.0347532.ref054","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/acschemneuro.0c00308","article-title":"Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration","volume":"12","author":"D Patnaik","year":"2021","journal-title":"ACS Chem Neurosci"},{"issue":"10","key":"pone.0347532.ref055","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.4161\/auto.7.10.15904","article-title":"GABARAPL1 (GEC1): original or copycat?","volume":"7","author":"JN Le Grand","year":"2011","journal-title":"Autophagy"},{"issue":"1","key":"pone.0347532.ref056","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1038\/s41467-022-32462-2","article-title":"Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia","volume":"13","author":"B Jablonska","year":"2022","journal-title":"Nat Commun"},{"key":"pone.0347532.ref057","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fncel.2016.00230","article-title":"Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice","volume":"10","author":"C Vastagh","year":"2016","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"pone.0347532.ref058","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/jnc.15771","article-title":"Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling","volume":"164","author":"Y Peng","year":"2023","journal-title":"J Neurochem"},{"issue":"6","key":"pone.0347532.ref059","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s11596-023-2792-8","article-title":"P25\/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice","volume":"43","author":"J Yu","year":"2023","journal-title":"Curr Med Sci"},{"key":"pone.0347532.ref060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.seizure.2022.07.007","article-title":"Genetic variations in GABA metabolism and epilepsy","volume":"101","author":"Y Feng","year":"2022","journal-title":"Seizure"},{"issue":"6","key":"pone.0347532.ref061","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.biopsych.2009.11.008","article-title":"Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment","volume":"67","author":"C Sgobio","year":"2010","journal-title":"Biol Psychiatry"},{"key":"pone.0347532.ref062","doi-asserted-by":"crossref","first-page":"1304300","DOI":"10.3389\/fpsyt.2024.1304300","article-title":"Understanding the role of AMPA receptors in autism: insights from circuit and synapse dysfunction","volume":"15","author":"A Jimenez-Gomez","year":"2024","journal-title":"Front Psychiatry"},{"issue":"12","key":"pone.0347532.ref063","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.7150\/thno.43716","article-title":"Parthenolide ameliorates colon inflammation through regulating Treg\/Th17 balance in a gut microbiota-dependent manner","volume":"10","author":"Y-J Liu","year":"2020","journal-title":"Theranostics"},{"key":"pone.0347532.ref064","doi-asserted-by":"crossref","first-page":"943384","DOI":"10.3389\/fmolb.2022.943384","article-title":"A comprehensive prognostic and immunological analysis of ephrin family genes in hepatocellular carcinoma","volume":"9","author":"S Huang","year":"2022","journal-title":"Front Mol Biosci"},{"key":"pone.0347532.ref065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neures.2022.09.008","article-title":"Microglia and GABA: Diverse functions of microglia beyond GABA-receiving cells","volume":"187","author":"M Andoh","year":"2023","journal-title":"Neurosci Res"},{"issue":"6","key":"pone.0347532.ref066","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3390\/v14061210","article-title":"EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death","volume":"14","author":"CW Lehman","year":"2022","journal-title":"Viruses"},{"issue":"2","key":"pone.0347532.ref067","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000520501","article-title":"AXL and MET in hepatocellular carcinoma: a systematic literature review","volume":"11","author":"C-H Hsu","year":"2022","journal-title":"Liver Cancer"},{"issue":"1","key":"pone.0347532.ref068","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13045-020-00944-9","article-title":"Targeting EphA2 in cancer","volume":"13","author":"T Xiao","year":"2020","journal-title":"J Hematol Oncol"},{"issue":"2","key":"pone.0347532.ref069","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.nbd.2010.09.019","article-title":"17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease","volume":"41","author":"S Massone","year":"2011","journal-title":"Neurobiol Dis"},{"issue":"5","key":"pone.0347532.ref070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/glia.20945","article-title":"Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis","volume":"58","author":"M Moransard","year":"2010","journal-title":"Glia"},{"key":"pone.0347532.ref071","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.stemcr.2019.01.015","article-title":"Dual Inhibition of GSK3\u03b2 and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo","volume":"12","author":"L Reinhardt","year":"2019","journal-title":"Stem Cell Reports"},{"issue":"6","key":"pone.0347532.ref072","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/neuonc\/noab290","article-title":"Neuronal exposure induces neurotransmitter signaling and synaptic mediators in tumors early in brain metastasis","volume":"24","author":"K Deshpande","year":"2022","journal-title":"Neuro Oncol"},{"key":"pone.0347532.ref073","doi-asserted-by":"crossref","first-page":"102108","DOI":"10.1016\/j.pneurobio.2021.102108","article-title":"Replicating infant-specific reactive astrocyte functions in the injured adult brain","volume":"204","author":"L Teo","year":"2021","journal-title":"Prog Neurobiol"},{"key":"pone.0347532.ref074","doi-asserted-by":"crossref","first-page":"105961","DOI":"10.1016\/j.nbd.2022.105961","article-title":"Differences in junction-associated gene expression changes in three rat models of diabetic retinopathy with similar neurovascular phenotype","volume":"176","author":"M Kolibabka","year":"2023","journal-title":"Neurobiol Dis"},{"issue":"3","key":"pone.0347532.ref075","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.neuroscience.2008.08.008","article-title":"Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons","volume":"156","author":"J Grabert","year":"2008","journal-title":"Neuroscience"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0347532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:31:15Z","timestamp":1776706275000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0347532"}},"subtitle":[],"editor":[{"given":"Kenji","family":"Tanigaki","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":75,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0347532","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}