{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:08:18Z","timestamp":1779300498435,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the corneal biomechanical and biometric properties in immunoglobulin G4-related ophthalmic disease (IgG4-ROD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Ethnic Han Chinese biopsy-proven IgG4-ROD patients from a territory wide cohort and sex-, age-, smoking- and lens status-matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A case-controlled (1:1) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Corvis ST analyzer and IOL Master 700 biometry assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty-seven eyes from 67 patients with IgG4-ROD (41\u2009=\u2009males), aged 63.9\u2009\u00b1\u200913.1 years and 67 right eyes from 67 healthy ethnically\u00a0Han Chinese controls were recruited. IgG4-ROD eyes were associated with a more negative applanation 2 velocity (\u22120.30 versus \u22120.27 m\/s,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0143), and reduced radius of curvature (7.48 versus 7.98\u2009mm,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0136). There was no difference in intraocular pressure, applanation 1 length, applanation 1 velocity, applanation 2 length, deformation amplitude and peak distance. Corneal astigmatism was greater in IgG4-ROD eyes (\u22121.2 versus \u22120.9 D\n                      <jats:italic>, P<\/jats:italic>\n                      \u2009=\u20090.0132), and the deep axis is along 90.2\u2009degree. There is no difference in the steep and flat keratometry, deep axis, lens thickness, cornea thickness, and anterior chamber depth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec006\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found multiple corneal changes in biomechanics and fine structures in a cohort of biopsy-proven IgG4-ROD with potential long-term implications in ocular surface functions. A longitudinal follow-up would be useful to identify the clinical implications and observe if these changes improve with treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0347998","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:30:25Z","timestamp":1779298225000},"page":"e0347998","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cornea biomechanics and biometric evaluations in immunoglobulin G4-related ophthalmic disease"],"prefix":"10.1371","volume":"21","author":[{"given":"Kenneth Ka Hei","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema Mohamed Ali Abdulla","family":"Aljufairi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake 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