{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:16:47Z","timestamp":1777871807450,"version":"3.51.4"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>nsedated colonoscopy is often associated with patient discomfort and may increase procedural difficulty for endoscopists. This study aimed to investigate the influence of perianal lidocaine application on the comfort level of patients and endoscopic operations during unsedated colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>122 patients aged 18\u201340 years were enrolled and randomly allocated to colonoscopy with 2% lidocaine (experiment group, n\u2009=\u200961) or normal saline (control, n\u2009=\u200961) smeared around the anus. The primary outcomes were anal pain score and abdominal pain score during and after colonoscopy, assessed using a visual analogue scale (VAS). Secondary outcomes included cecal intubation time, polyp detection rate, adenoma detection rate, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistical difference between groups in terms of abdominal pain scores during unsedated colonoscopy. Abdominal pain scores after colonoscopy were significantly lower in the lidocaine group than in the saline group. (P\u2009&lt;\u20090.001). However, the lidocaine group had significantly lower anal pain scores during and after colonoscopy (P\u2009&lt;\u20090.001) and a shorter cecal intubation time (P\u2009&lt;\u20090.001). Polyp and adenoma detection rates were higher in the lidocaine group (P\u2009&lt;\u20090.05). Junior endoscopists achieved greater improvements in these outcomes compared to senior endoscopists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Perianal application of lidocaine may reduce anal pain and may improve procedural efficiency during unsedated colonoscopy, particularly among junior endoscopists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0348062","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:31:26Z","timestamp":1777570286000},"page":"e0348062","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perianal lidocaine application during unsedated colonoscopy: A double-blind randomized controlled trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9956-8377","authenticated-orcid":true,"given":"Jiankun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhining","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0178-5195","authenticated-orcid":true,"given":"Wentao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"issue":"6","key":"pone.0348062.ref001","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.mcna.2020.08.004","article-title":"Screening for Colorectal Cancer","volume":"104","author":"EM Montminy","year":"2020","journal-title":"Med Clin North Am"},{"issue":"1","key":"pone.0348062.ref002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1756283X16670076","article-title":"Antispasmodic drugs in colonoscopy: a review of their pharmacology, safety and efficacy in improving polyp detection and related outcomes","volume":"10","author":"S Sanagapalli","year":"2017","journal-title":"Ther Adv Gastroenterol"},{"issue":"2","key":"pone.0348062.ref003","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/den.13272","article-title":"Inhibitory effect of lidocaine on colonic spasm during colonoscopy: A multicenter double-blind, randomized controlled trial","volume":"31","author":"D Nemoto","year":"2019","journal-title":"Dig Endosc"},{"issue":"3","key":"pone.0348062.ref004","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/02813432.2018.1487520","article-title":"Why do some participants in colorectal cancer screening choose not to undergo colonoscopy following a positive test result? 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