{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:39:36Z","timestamp":1777315176879,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project of Shanghai Municipal Science and Technology Commission","award":["20Y21900300"],"award-info":[{"award-number":["20Y21900300"]}]},{"name":"the Scientific Research Project of Anhui Provincial Department of Education","award":["2025AHGXZK30119"],"award-info":[{"award-number":["2025AHGXZK30119"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sepsis-induced coagulopathy (SIC) is associated with high mortality. This study aimed to explore the predictive value of baseline red blood cell distribution width (RDW) and its dynamic trajectory for 30-day all-cause mortality in SIC patients, and to develop a practical nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted on 2531 SIC patients from the MIMIC-IV v3.1 database. Patients were grouped by baseline RDW tertiles, and RDW dynamic trajectories were constructed via Latent Class Growth Mixture Model (LCGMM). Kaplan-Meier analysis, Cox proportional hazards regression, and Restricted Cubic Spline (RCS) model were applied to assess the association between RDW and 30-day mortality. A nomogram was built via Boruta algorithm and Lasso regression, with external validation in 317 patients from a Shanghai tertiary hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      30-day mortality increased with elevated baseline RDW (Q1: 4.5% vs. Q2: 10.7% vs. Q3: 22.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and Q3 was an independent risk factor (adjusted HR\u2009=\u20092.666, 95%CI: 1.854\u20133.834). RDW&gt; about 15% correlated with sustained mortality risk. LCGMM identified two trajectories (stable low-level Traj0, rapidly ascending Traj1), with Traj1 showing higher mortality (31.1% vs. 10.0%, adjusted HR\u2009=\u20092.522). The nomogram integrating RDW and clinical indicators demonstrated good discrimination (C-index\u2009=\u20090.805, AUC\u2009=\u20090.813) and utility.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High baseline RDW and rapidly ascending RDW trajectory are independent risk factors for 30-day mortality in SIC patients. The nomogram enables convenient and accurate risk stratification and prognostic evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0348149","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:44:47Z","timestamp":1777311887000},"page":"e0348149","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline RDW combined with dynamic trajectory: Predictive value for 30-day all-cause mortality in patients with sepsis-induced coagulopathy and development of a nomogram"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2884-6177","authenticated-orcid":true,"given":"Ying","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"4","key":"pone.0348149.ref001","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1213\/ANE.0000000000006888","article-title":"Sepsis-induced coagulopathy: a comprehensive narrative review of pathophysiology, clinical presentation, diagnosis, and management 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