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Deforestation can reduce biodiversity and increase pathogen prevalence in triatomine populations; however, the effects of landscape structure on triatomine infection patterns remain poorly understood. Here, we address this knowledge gap by examining how forest cover and proximity to human dwellings influence triatomine infection patterns across gradients of deforestation. Field surveys were conducted in 2022 and 2024 in 20 landscape units in Cruzeiro do Sul, Acre state, Brazil, where triatomines were collected from palm trees located at varying distances from inhabited households. Distances and land-use composition were quantified from high-resolution drone and satellite imagery, while parasite infections were identified using molecular assays. Bayesian binomial mixed-effects models revealed contrasting responses between parasites.\n                    <jats:italic>T<\/jats:italic>\n                    .\n                    <jats:italic>cruzi<\/jats:italic>\n                    infection probability was higher in more deforested landscapes and was further modulated by palm-household distance, with the strongest effects observed for palms closer to dwellings. In contrast,\n                    <jats:italic>T<\/jats:italic>\n                    .\n                    <jats:italic>rangeli<\/jats:italic>\n                    infection showed no supported association with forest cover or distance to households. Blood meal analysis revealed frequent feeding on sylvatic hosts, particularly marsupials, and detected human blood in a nymph collected only 33 m from a household;\n                    <jats:italic>T<\/jats:italic>\n                    .\n                    <jats:italic>cruzi<\/jats:italic>\n                    infections detected in the study were exclusively assigned to TcI discrete typing unit, a lineage commonly associated with sylvatic transmission. These findings demonstrate that deforestation reshapes host-vector-parasite interactions in palm-based systems, increasing spillover risk at the sylvatic-human interface without requiring domiciliated triatomines.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0349311","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:26:33Z","timestamp":1779125193000},"page":"e0349311","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deforestation and human proximity influence Trypanosoma cruzi infection in palm-dwelling triatomines"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-9390","authenticated-orcid":true,"given":"Gabriel Z.","family":"Laporta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro J.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla M.","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wandercleyson U.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto C.","family":"Ilacqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa S.","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia F.","family":"Brilhante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda P.","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionatas U. O.","family":"Meneguetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredy","family":"Galvis-Ovallos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2809-0434","authenticated-orcid":true,"given":"Paula R.","family":"Prist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-3747","authenticated-orcid":true,"given":"Marcia 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