{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:16:08Z","timestamp":1778868968575,"version":"3.51.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Clinical Construction Specialist Project","award":["HYSZXYYGJZD001"],"award-info":[{"award-number":["HYSZXYYGJZD001"]}]},{"name":"Clinical Medical Technology Demonstration Base For Emergency Treatment of Chest Pain in Hunan Province","award":["2021SK4037"],"award-info":[{"award-number":["2021SK4037"]}]},{"name":"2025 Hengyang \u201cXiaohe\u201d Young Talents in Science and Technology Special Project","award":["2025HYXHRC-2025018"],"award-info":[{"award-number":["2025HYXHRC-2025018"]}]},{"name":"2025 Hengyang Science and Technology Innovation Plan Project","award":["202550038016"],"award-info":[{"award-number":["202550038016"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ81819"],"award-info":[{"award-number":["2026JJ81819"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Hunan Province in 2025","award":["2025JJ80594"],"award-info":[{"award-number":["2025JJ80594"]}]},{"name":"Scientific Research Project of Hunan Nursing Association","award":["HNKYP202413"],"award-info":[{"award-number":["HNKYP202413"]}]},{"name":"Young Talent Project of Hunan Nursing Association","award":["Q20241204020"],"award-info":[{"award-number":["Q20241204020"]}]},{"name":"Health Research Project of Hunan Provincial Health","award":["W20243278"],"award-info":[{"award-number":["W20243278"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n Quality of life (QoL) is a pivotal prognostic indicator for patients with Type 2 Diabetes Mellitus (T2DM). While the impact of various factors on QoL is recognized, the complex interplay between psychological and behavioral determinants remains underexplored. Understanding these pathways is essential for developing effective interventions.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to investigate the status of QoL and its associated factors among T2DM patients, and to examine the mediating effects of personal mastery (PM) and health-promoting behaviors (HPB) in the relationship between self-regulatory fatigue (SRF) and QoL by using structural equation modeling.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study adhered to the STROBE guidelines for cross-sectional reporting. From July 2025 to February 2026, 432 T2DM patients were recruited from three tertiary grade-A hospitals across two cities in China by using convenience sampling. Data were collected using the Demographic Characteristics Questionnaire, Self-Regulatory Fatigue Scale, Personal Mastery Scale, Diabetes Health Promotion Scale, and Diabetes-Specific Quality of Life Scale. Pearson\u2019s correlation, multiple linear regression, and structural equation modeling were employed for data analysis. The mediating effects were tested using the bias-corrected (BC) bootstrap method with 5,000 resamples.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The total scores for SRF, PM, HPB, and QoL were 38.63\u2009\u00b1\u200912.84, 26.12\u2009\u00b1\u20097.62, 97.69\u2009\u00b1\u200920.87, and 69.41\u2009\u00b1\u200920.89, respectively. Correlation analysis indicated that QoL was significantly positively correlated with SRF (\n r<\/jats:italic>\n \u2009=\u20090.581,\n p<\/jats:italic>\n \u2009<\u20090.01), and negatively correlated with PM (\n r<\/jats:italic>\n \u2009=\u2009\u22120.557,\n p<\/jats:italic>\n \u2009<\u20090.01) and HPB (\n r<\/jats:italic>\n \u2009=\u2009\u22120.613,\n p<\/jats:italic>\n \u2009<\u20090.01). Multiple linear regression analysis revealed that age, educational level, medical insurance payment method, smoking status, glycemic control status, number of comorbidities, self-care ability, self-regulatory fatigue, personal mastery, and health-promoting behaviors were independent predictors of QoL. Furthermore, the structural equation modeling demonstrated a significant total indirect effect of self-regulatory fatigue on QoL. The mediating effect of personal mastery accounted for 30.2% of the total indirect effect, while that of health-promoting behaviors explained 60.2%. The chain mediating pathway contributed 9.5% of the total indirect effect.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study suggests that SRF is statistically associated with directly and indirectly poorer QoL in T2DM patients, primarily by being associated with lower PM and fewer HPB. These findings highlight the importance of addressing psychological and behavioral mechanisms in diabetes care. From a nursing perspective, interventions targeting SRF, strengthening PM, and promoting HPB may be beneficial.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0349561","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:54:26Z","timestamp":1778867666000},"page":"e0349561","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The mediating roles of personal mastery and health-promoting behaviors in the relationship between self-regulatory fatigue and quality of life among patients with type 2 diabetes mellitus"],"prefix":"10.1371","volume":"21","author":[{"given":"Guiqiu","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youxing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyun","family":"Ru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-8848","authenticated-orcid":true,"given":"Zhangyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"pone.0349561.ref001","volume-title":"Guidelines for the prevention and treatment of diabetes in China (2024 Edition)","author":"Chinese Diabetes Society","year":"2024"},{"issue":"5","key":"pone.0349561.ref002","first-page":"357","article-title":"Comprehensive management strategy for chronic complications of diabetes","volume":"38","author":"L Ji","year":"2022","journal-title":"Chin J Endocrinol Metab"},{"issue":"8","key":"pone.0349561.ref003","first-page":"561","article-title":"Analysis of epidemiological characteristics of diabetes in China","volume":"32","author":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention","year":"2024","journal-title":"Chin Prev Chronic Dis"},{"issue":"7","key":"pone.0349561.ref004","first-page":"8","article-title":"Current status and prediction of global economic burden of diabetes","volume":"42","author":"Q Meng","year":"2023","journal-title":"Chin Health Economics"},{"key":"pone.0349561.ref005","volume-title":"Guidelines for the prevention and treatment of diabetes in China (2024 Edition)","author":"Chinese Diabetes Society","year":"2024"},{"key":"pone.0349561.ref006","unstructured":"World Health Organization. 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