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Although cadmium\u2013zinc\u2013tellurite\u00a0(CZT) detectors have emerged as potential solutions to this growing demand, the lack of comprehensive characterization data for these detectors deters their application in clinical electron-beam dosimetry, especially for high-precision tasks such as small-field and point-dose dosimetry. In this study, we systematically characterized CZT detectors, emphasizing the performance trade-offs associated with detector thickness for therapeutic electron-beam dosimetry. The performance of two CZT detectors (6\u2009\u00d7\u20096 mm\u00b2), with thicknesses of 5 and 8 mm, was evaluated using a clinical linear accelerator (LINAC) over an electron energy range of 6\u201318 MeV. Both detectors demonstrated stable baseline performance, including proportional dose linearity (R\u00b2\u2009&gt;\u20090.997), dose-rate independence, and excellent long-term stability (&lt;1.3% variation over two months). Furthermore, a distinct thickness-dependent trade-off was identified: while both configurations exhibited highly comparable dose responses at the 6-MeV baseline, the 8-mm detector exhibited better energy capture efficiency for higher-energy electrons. By contrast, the 5\u2011mm detector offered enhanced angular isotropy with respect to the gantry angle as well as reduced signal variation (\u00b13.5% vs.\u2009\u00b1\u20096.4%), emerging as more suitable for rotational therapies and geometrically demanding scenarios. Additionally, a nonmonotonic energy dependence was observed, characterized by a pronounced response peak at 15 MeV, which was likely attributable to bremsstrahlung photon contamination from the LINAC head. These findings demonstrate that detector thickness serves as an application-specific optimization factor for sensitivity and angular fidelity, offering a practical framework for deploying CZT detectors in both initial clinical evaluations and challenging extra-clinical radiation environments.<\/jats:p>","DOI":"10.1371\/journal.pone.0349698","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:12:49Z","timestamp":1782846769000},"page":"e0349698","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dosimetric characterization of CdZnTe radiation detectors under electron-beam 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