{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:50:15Z","timestamp":1788918615609,"version":"build-2803163510"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","award":["A43194"],"award-info":[{"award-number":["A43194"]}],"id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["0079241"],"award-info":[{"award-number":["0079241"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF20SA0067242"],"award-info":[{"award-number":["NNF20SA0067242"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Acute heart failure (AHF) is the cause of one in twenty hospital admissions. Supplemental oxygen therapy is a routine treatment in the management of patients with dyspnea, including those with AHF. Current guidelines recommend oxygen therapy as part of the initial treatment, if peripheral oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) is\u2009&lt;\u200990% or partial pressure of arterial oxygen (PaO\n                      <jats:sub>2<\/jats:sub>\n                      ) is\u2009&lt;\u200960 mmHg to correct hypoxemia. There is no clear evidence favoring restrictive or liberal oxygenation strategies in patients with acute heart failure. The aim of this study is to compare restrictive and liberal oxygenation strategies in patients hospitalized for acute heart failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study is an investigator-initiated, multicenter, prospective, double-blinded, randomized clinical trial. Patients are randomized in a 1:1 fashion to receive one of the two treatment-strategies: liberal oxygenation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      target of 96%) or restrictive oxygenation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      target of 90%). The intervention is administrated double-blinded using an automated oxygen administration device, titrating the oxygen supplementation towards the intended target SpO\n                      <jats:sub>2<\/jats:sub>\n                      without it being visible for patients, investigators or clinical staff. The primary outcome is pulmonary congestion, measured by remote dielectric sensing (ReDS) after 24 hours, adjusted for baseline measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study will explore the current uncertainty regarding restrictive and liberal oxygenation targets in acute heart failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0349791","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T17:40:22Z","timestamp":1779471622000},"page":"e0349791","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Restrictive versus liberal oxygenation targets in patients with acute heart failure and pulmonary congestion\u2013A protocol for a Randomized Controlled Trial (The REDOX-AHF 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Wendelboe","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-0981","authenticated-orcid":true,"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Jakob","family":"Thune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Noory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Karamat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens 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