{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:05:38Z","timestamp":1784225138026,"version":"3.55.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of a pharmacist\u2011led educational intervention on medication knowledge, adherence, and asthma control among adult asthma patients at Ayder Comprehensive Specialized Hospital, Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2011blind, parallel\u2011group randomized controlled trial will be conducted. All eligible adult asthma patients on active follow\u2011up at the chest clinic of Ayder Comprehensive Specialized Hospital will be included. Participants will be randomly assigned via a computer\u2011generated sequence to an intervention group (structured pharmacist\u2011led education using teach\u2011back, illustrated pamphlets, a follow\u2011up phone call and SMS) or a control group (routine care). Outcome assessors will be blinded to group allocation. Outcomes will be measured at baseline and after three months, including medication adherence (GMAS), asthma control (ACT), medication knowledge, correct inhaler technique, and domain\u2011specific adherence barriers. Data will be analyzed using intention\u2011to\u2011treat with multivariable binary logistic regression, chi\u2011square tests, independent T-test, McNemar\u00a0test, Mann\u2011Whitney U test, and\u00a0Fisher\u2019s\u00a0exact test where appropriate. Subgroup analyses will be performed to explore whether the intervention effect differs across patient characteristics. A p\u2011value\u2009&lt;\u20090.05 will be considered statistically significant, with 95% confidence intervals reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Trial registry<\/jats:title>\n                    <jats:p>Pan African Clinical Trials Registry (PACTR202508565637179).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0349805","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:30:43Z","timestamp":1784223043000},"page":"e0349805","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacist-led educational intervention to improve knowledge, medication adherence, and asthma control among asthma patients at Ayder Comprehensive Specialized Hospital: A protocol for randomized controlled 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Gebremeskel","family":"Tsadik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"3","key":"pone.0349805.ref001","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/arm91030020","article-title":"Effect of Pharmacist-Led Interventions on Medication Adherence among Vietnamese Patients with Asthma: A Randomized Controlled Trial","volume":"91","author":"TT Nguyen","year":"2023","journal-title":"Adv Respir Med"},{"key":"pone.0349805.ref002","unstructured":"Relat\u00f3rio Principal GINA 2024 - Iniciativa Global para a Asma - GINA. 2024. https:\/\/ginasthma.org\/2024-report\/"},{"issue":"3","key":"pone.0349805.ref003","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pccm.2024.08.004","article-title":"Patterns and trends in asthma incidence rates in main Asian and Western countries and their prediction to 2030","volume":"2","author":"Y 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