{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:06:28Z","timestamp":1779473188691,"version":"3.53.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1F1A1063404"],"award-info":[{"award-number":["2022R1F1A1063404"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Many adults with type 2 diabetes mellitus (T2DM) managed without insulin continue to experience suboptimally controlled glycemia. This 12-week, single-arm pilot feasibility study was conducted across 11 community pharmacies in South Korea to evaluate the feasibility and clinical effectiveness of a community pharmacy-led diabetes management model using continuous glucose monitoring (CGM) integrated with digital health platforms. Thirty adults with suboptimally controlled T2DM (HbA1c\u2009\u2265\u20096.5%) on stable oral regimens were enrolled. The intervention combined medication, exercise, and nutrition counseling using CGM (Abbott LibreView\u00ae) integrated with the national Personal Health Record system. The primary composite endpoint was defined as achieving all three at week 12: (1) HbA1c\u2009\u2264\u20097.0%, (2) meaningful HbA1c reduction (\u22650.5% absolute or \u226510% relative), and (3) time in range (TIR, 70\u2013180 mg\/dL) &gt;70%. Results showed that all 30 participants completed the program, with 36.7% achieving the primary composite endpoint. At week 12, HbA1c decreased by 0.70% (95% CI: \u20131.00 to \u20130.39; p\u2009&lt;\u20090.001), TIR increased by 5.8 percentage points (p\u2009&lt;\u20090.001), and time above range declined. Time below range remained stable, confirming safety. Improvements appeared from week 3 and were sustained, with longer diabetes duration independently predicting response (adjusted OR=1.24\/year, p\u2009=\u20090.040). In conclusion, community pharmacy-led diabetes management using CGM, enabled by digital health integration, produced clinically meaningful and sustained glycemic improvements among adults with T2DM not using insulin. (Trial Registration: KCT0010933).<\/jats:p>","DOI":"10.1371\/journal.pone.0350025","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T17:36:51Z","timestamp":1779471411000},"page":"e0350025","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Community pharmacy-led diabetes management using continuous glucose monitoring for suboptimally controlled type 2 diabetes: A pilot feasibility study"],"prefix":"10.1371","volume":"21","author":[{"given":"Kyung-In","family":"Joung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Han","family":"Back","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Geun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-0748","authenticated-orcid":true,"given":"Kwang Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"pone.0350025.ref001","article-title":"Diagnosis and classification of diabetes: standards of care in diabetes-2025","volume":"48","author":"American Diabetes Association Professional Practice Committee","year":"2025","journal-title":"Diabetes Care"},{"key":"pone.0350025.ref002","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"H Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"issue":"12","key":"pone.0350025.ref003","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00125-022-05787-2","article-title":"Management of hyperglycaemia in type 2 diabetes, 2022. 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