{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:00:20Z","timestamp":1791396020753,"version":"4.3.3"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>This study presents a novel computational framework for nanoparticle-assisted drug delivery in abdominal aortic aneurysm (AAA) by characterizing patient-specific hemodynamics under realistic physiological conditions with integrating an artificial neural network (ANN). The model incorporates silver (Ag) nanoparticles within a fully transient, multiphase computational fluid dynamics (CFD) environment, where pulsatile blood flow is imposed using advanced user-defined function. Blood is modeled as a non-Newtonian fluid to capture its shear-dependent rheological behavior, enabling a more accurate representation of vascular flow dynamics. High-resolution patient-specific geometries are developed to investigate four distinct cases, including healthy and AAA arteries with varying geometrical complexities and multiple daughter vessels, both with and without nanoparticle infusion. The analysis focuses on key clinically relevant hemodynamic indicators, including velocity, normal and tangential wall shear stress (WSS). The results indicate that arterial geometry and blood rheology play a dominant role in governing flow behavior, with the most complex vascular configuration exhibiting the strongest hemodynamic response. Among the investigated cases, model 3 shows the highest velocity, decreasing by 52.94% compared to the healthy artery (model 1), while models 2 and 4 exhibit decreases of 82.35% and 54.90%, respectively at left iliac. The introduction of Ag nanoparticles enhances WSS across all models by 34.72%, 47.32%, 51.92%, and 39.67%, respectively, indicating improved flow modulation and more favorable conditions for drug transport and vascular interaction. Flow visualization reveals distinct regions of acceleration, recirculation, and nanoparticle accumulation, which are critical for understanding localized delivery mechanisms. The ANN confirming the robustness, accuracy, and predictive reliability of the developed models. Finally, the proposed framework establishes a clear relationship between arterial morphology, non-Newtonian blood behavior, and nanoparticle-driven hemodynamic modulation, offering valuable insights for optimizing patient-specific, nanoparticle-based therapeutic strategies in cardiovascular disease management.<\/jats:p>","DOI":"10.1371\/journal.pone.0350224","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:35:31Z","timestamp":1791394531000},"page":"e0350224","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computational investigation and machine learning prediction of nanoparticle effects on hemodynamics in patient-specific aortic aneurysms"],"prefix":"10.1371","volume":"21","author":[{"given":"Mohammad Abdul Karim","family":"Khan","sequence":"first","affiliation":[{"name":"Jahangirnagar University","place":["Dhaka, Bangladesh"],"department":["Department of Mathematics"]},{"name":"Ahsanullah University of Science and Technology (AUST)","place":["Dhaka, Bangladesh"],"department":["Department of Arts and Sciences, Faculty of Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-1850","authenticated-orcid":true,"given":"Kazi Ekramul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Ahsanullah University of Science and Technology (AUST)","place":["Dhaka, Bangladesh"],"department":["Department of Arts and Sciences, Faculty of Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Osman","family":"Gani","sequence":"additional","affiliation":[{"name":"Jahangirnagar University","place":["Dhaka, Bangladesh"],"department":["Department of Mathematics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayema Islam","family":"Nima","sequence":"additional","affiliation":[{"name":"Independent University Bangladesh 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Computational simulation of nanoparticle behavior using artificial neural networks. 2025;0(0):1\u20136.","DOI":"10.2139\/ssrn.6200838"},{"key":"pone.0350224.ref072","doi-asserted-by":"crossref","first-page":"100554","DOI":"10.1016\/j.ijft.2023.100554","article-title":"The effect of bifurcation angulation on flow characteristics and hemodynamic indicators in an idealized left coronary artery","volume":"21","author":"A M\u00fcft\u00fco\u011fullar\u0131","year":"2024","journal-title":"International Journal of Thermofluids"},{"issue":"5","key":"pone.0350224.ref073","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1177\/09544089221080273","article-title":"Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3\/blood) based drug delivery through a bell-shaped occluded artery with joule heating, viscous dissipation and variable viscosity effects","volume":"236","author":"R Gandhi","year":"2022","journal-title":"Proc Inst Mech Eng Part E J Process Mech Eng"},{"issue":"1","key":"pone.0350224.ref074","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4314\/njtd.v20i1.1293","article-title":"Computational model of nano-pharmacological particles for the clinical management of stenotic and aneurysmatic coronary artery in the human body","volume":"20","author":"IA Fetuga","year":"2023","journal-title":"Niger J Technol Dev"},{"key":"pone.0350224.ref075","unstructured":"Costa ED. Hemodynamics in the left coronary artery - numerical and in vitro approaches. 2016;252."},{"issue":"4","key":"pone.0350224.ref076","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317989","article-title":"Modeling and simulation of blood flow in unhealthy elliptic arteries with computational fluid dynamics approach","volume":"20","author":"A Wahab","year":"2025","journal-title":"PLoS One"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0350224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:35:44Z","timestamp":1791394544000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0350224"}},"subtitle":[],"editor":[{"given":"Hafiz Muhammad Umer","family":"Farooqi","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Orange County","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":76,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0350224","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}