{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:04:52Z","timestamp":1780077892418,"version":"3.54.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["EDCTP TMA2019SFP-2812"],"award-info":[{"award-number":["EDCTP TMA2019SFP-2812"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Adolescents and young adults living with HIV (AYALHIV) face persistent challenges with antiretroviral therapy (ART) adherence, a key determinant of viral suppression and long-term health outcomes. The\n                      <jats:italic>Lu Dedoo Project<\/jats:italic>\n                      sought to adapt the existing (Masakhane Siphucule Impilo Yethu (MASI) adherence app, originally developed for South Africa, for AYALHIV in Benue State, Nigeria. Guided by a human-centered design (HCD) framework, the project engaged end users to ensure that the app was contextually relevant, user-friendly, and responsive to local needs prior to pilot testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Beta testing was conducted where purposively selected AYALHIV used MASI in its existing form for one month. Three subsequent FGDs were held among beta testers, involving a total of 22 participants: one mixed-gender adolescent group aged 15\u201319 years (n\u2009=\u20096), one male young adult group aged 20\u201324 years (n\u2009=\u20098), and one female young adult group aged 20\u201324 years (n\u2009=\u20098). FGDs were analysed using thematic analysis in NVivo\u00ae v15. Transcripts were analysed thematically to identify user experiences and desired modifications. Identified features were then prioritised using the MoSCoW method (\u201cMust have,\u201d \u201cShould have,\u201d \u201cCould have,\u201d \u201cWon\u2019t have\u201d) to guide development decisions and ensure feasible, user-driven adaptation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants found the app highly engaging and liked the games, quizzes, and the ability to earn badges. These features contributed to user retention and supported their medication adherence. A subset of participants noted the challenge of needing cellular data access to use the app. \u201cMust have\u201d priorities included offline access to key features, simplified navigation, and customizable medication reminders. \u201cShould have\u201d and \u201cCould have\u201d priorities included adding more engaging media content and enhancing personalised reminders to better meet user needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Applying an HCD framework, complemented by MoSCoW prioritisation, provided a structured and participatory pathway for adapting an mHealth adherence app to the Nigerian context. The process ensured that core user needs guided technical decisions and that limited development resources were directed toward high-impact features. The adapted\n                      <jats:italic>Lu Dedoo<\/jats:italic>\n                      app reflects local preferences for functionality, language, and offline usability, and represents a promising, context-specific tool for improving ART adherence among AYALHIV.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0350279","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:34:55Z","timestamp":1780076095000},"page":"e0350279","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adapting a medication adherence app for adolescents and young adults in Makurdi, Benue State: The Lu Dedoo Project"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-5400","authenticated-orcid":true,"given":"Olaposi Joseph","family":"Olatoregun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-923X","authenticated-orcid":true,"given":"Lisa","family":"Hightow-Weidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mulawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Osi","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper","family":"Okonkwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-7475","authenticated-orcid":true,"given":"Catherine","family":"Orrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"issue":"3","key":"pone.0350279.ref001","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/tmi.13854","article-title":"Virological failure and adherence to antiretroviral therapy in adolescents and young adults living with human immunodeficiency virus","volume":"28","author":"ACB Daltro","year":"2023","journal-title":"Trop Med Int Health"},{"issue":"1","key":"pone.0350279.ref002","doi-asserted-by":"crossref","DOI":"10.4102\/phcfm.v11i1.1740","article-title":"Social and economic barriers to adherence among patients at Livingstone General Hospital in Zambia","volume":"11","author":"K Moomba","year":"2019","journal-title":"Afr J Prim Health Care Fam Med"},{"issue":"1","key":"pone.0350279.ref003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/2374373518770805","article-title":"Facilitators and Barriers Affecting Adherence Among People Living With HIV\/AIDS: A Qualitative Perspective","volume":"6","author":"SI Ahmed","year":"2019","journal-title":"J Patient Exp"},{"issue":"1","key":"pone.0350279.ref004","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00228-023-03571-8","article-title":"Socioeconomic factors associated with poor medication adherence in patients with type 2 diabetes","volume":"80","author":"M Ekenberg","year":"2024","journal-title":"Eur J Clin Pharmacol"},{"key":"pone.0350279.ref005","author":"NAIIS","year":"2019"},{"key":"pone.0350279.ref006","unstructured":"index Mundi. 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