{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:53:18Z","timestamp":1782496398718,"version":"3.54.5"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2023YFC2509300"],"award-info":[{"award-number":["2023YFC2509300"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["KCXFZ20201221173602007"],"award-info":[{"award-number":["KCXFZ20201221173602007"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n Prolonged occupational sedentary behavior has become a prevalent norm in workplaces, posing significant health risks. However, there is a scarcity of studies on the association between occupational sedentary behavior with metabolic syndrome (MetS) and related diseases among workers.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From June 2023 to November 2024, 2,055 male bus drivers (occupational sedentary group) and sanitation workers (non-sedentary group) were enrolled by cluster sampling. Questionnaire surveys and clinical examinations were collected retrospectively. MetS was diagnosed according to the\n Guidelines for the Prevention and Treatment of Diabetes Mellitus in China (2024 Edition)<\/jats:italic>\n . Logistic regressions and subgroup analyses were conducted to determine the associations between occupational sedentary behavior with MetS and related diseases.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The occupational sedentary group (1,158 participants) had higher prevalence of metabolic syndrome (24.61% vs. 22.63%), hypertriglyceridemia (51.81% vs. 36.34%), hypoalphalipoproteinemia (12.35% vs. 9.03%), and central obesity (36.62% vs. 29.43%), compared to the non-sedentary group (897 participants). In the logistic regression model, no significant correlations were observed between occupational sedentary behavior and MetS (\n P<\/jats:italic>\n \u2009>\u20090.05). Compared with non-sedentary group, the sedentary group showed an increased risks of hypertriglyceridemia [OR (95% CI) = 1.77 (1.41, 2.22)], hypoalphalipoproteinemia [OR (95% CI) = 1.44 (1.01, 2.06)], and central obesity [OR (95% CI) = 1.37 (1.09, 1.74)]. Subgroup logistic regression analysis showed that among subjects aged >55 years, the associations between occupational sedentary behavior with hypertriglyceridemia and central obesity were significantly stronger (all\n P<\/jats:italic>\n for interaction\u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Occupational sedentary behavior in males is associated with higher prevalence of hypertriglyceridemia, hypoalphalipoproteinemia, and central obesity. Interventions to reduce sedentary behavior are needed to mitigate these risks, such as lifestyle, and organizational management strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0350342","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:30:26Z","timestamp":1782495026000},"page":"e0350342","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between occupational sedentary behavior and metabolic syndrome and related diseases in males: A cross-sectional study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2348-7829","authenticated-orcid":true,"given":"Zhonglan","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7940-211X","authenticated-orcid":true,"given":"Shaofan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-593X","authenticated-orcid":true,"given":"Naixing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"issue":"1","key":"pone.0350342.ref001","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12966-017-0525-8","article-title":"Sedentary behavior research network (SBRN) - terminology consensus project process and outcome","volume":"14","author":"MS Tremblay","year":"2017","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"1","key":"pone.0350342.ref002","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12966-023-01537-8","article-title":"Device-measured movement behaviours in over 20,000 China Kadoorie Biobank participants","volume":"20","author":"Y Chen","year":"2023","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"3","key":"pone.0350342.ref003","first-page":"490","article-title":"Joint association of sedentary behavior and physical activity on anxiety tendency among occupational population in China","volume":"54","author":"YH Liu","year":"2022","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"12","key":"pone.0350342.ref004","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007508","article-title":"Association of sedentary time and incident heart failure hospitalization in postmenopausal women","volume":"13","author":"MJ LaMonte","year":"2020","journal-title":"Circ Heart Fail"},{"issue":"6","key":"pone.0350342.ref005","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4082\/kjfm.19.0089","article-title":"Association of sedentary time and physical activity with the 10-year risk of cardiovascular disease: Korea National Health and Nutrition Examination Survey 2014-2017","volume":"41","author":"Y Lee","year":"2020","journal-title":"Korean J Fam Med"},{"key":"pone.0350342.ref006","unstructured":"American Heart Association. 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