{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:19:31Z","timestamp":1787768371437,"version":"build-2784847793"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["15602024"],"award-info":[{"award-number":["15602024"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aphasia persists in 20% of the stroke population. Speech therapy has been suggested to benefit the functional communication of people with aphasia (PWA). Virtual reality (VR) has been widely applied in motor\/cognitive rehabilitation of stroke patients. The current proposal investigates the efficacy of VR-based computerized script training on the functional communication of PWA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A three-armed assessor-blinded randomized controlled trial (RCT) will recruit 120 PWA. They will be randomly assigned to 1) VR-based computerized script training, 2) computerized script training without VR, or 3) no treatment control. In the VR condition, PWA will practice in VR depicting everyday contexts, while in the non-VR group, PWA will practice with static photos. PWA in the control group will be assessed without training. Outcomes on functional communication, aphasia severity, and quality of life will be compared before\/after treatment. The findings will provide empirical evidence to inform the development of effective and ecologically valid interventions for PWA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06722092\" xlink:type=\"simple\">NCT06722092<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0350390","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:32:02Z","timestamp":1780421522000},"page":"e0350390","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can immersive virtual reality magnify treatment outcomes of computerized script training on Cantonese speakers with chronic aphasia? Protocol of a randomized controlled trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-2964","authenticated-orcid":true,"given":"Winsy Wing Sze","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald Shi Pui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Ngai Kuen","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Hiu Fung","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-9480","authenticated-orcid":true,"given":"Hoi Tsz Karen","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"6","key":"pone.0350390.ref001","first-page":"538","article-title":"Long-term outcome after discharge from a stroke rehabilitation unit","volume":"30","author":"HC Dijkerman","year":"1996","journal-title":"J R Coll Physicians Lond"},{"key":"pone.0350390.ref002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/09602010244000291","article-title":"The relevance of emotional and psychosocial factors in aphasia to rehabilitation","volume":"13","author":"C Code","year":"2003","journal-title":"Neuropsychol Rehabil"},{"issue":"6","key":"pone.0350390.ref003","article-title":"Speech and language therapy for aphasia following stroke","volume":"2016","author":"MC Brady","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"pone.0350390.ref004","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s11065-021-09531-2","article-title":"What is Functional Communication? 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Blomert","year":"1994","journal-title":"Aphasiology"},{"issue":"6","key":"pone.0350390.ref036","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1080\/02687038.2025.2495611","article-title":"Adaptation and investigation of validity and reliability measures of the communication outcome after stroke scale (COAST) for Cantonese speakers with aphasia: a preliminary study","volume":"40","author":"WWS Wong","year":"2025","journal-title":"Aphasiology"},{"issue":"12","key":"pone.0350390.ref037","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1177\/0269215508090091","article-title":"Development of a reliable self-report outcome measure for pragmatic trials of communication therapy following stroke: the Communication Outcome after Stroke (COAST) scale","volume":"22","author":"A Long","year":"2008","journal-title":"Clin 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